DRSC/TRiP Functional Genomics Resources

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Protein Alignment KIF21B and cmet

DIOPT Version :9

Sequence 1:NP_001239029.1 Gene:KIF21B / 23046 HGNCID:29442 Length:1637 Species:Homo sapiens
Sequence 2:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster


Alignment Length:1947 Identity:377/1947 - (19%)
Similarity:663/1947 - (34%) Gaps:709/1947 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    19 LSKEKIEGCHICTSVTPGEP------------QVLLGKDKA--FTYDFVFDLDTWQEQIYSTCVS 69
            :|.:......:|..|.|.||            .:.|....|  :.:|:|||.....::::.....
  Fly     1 MSAKNASSIQVCIKVRPCEPGLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65

Human    70 KLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDMATSEEEQGIIPRAIAHLFGGIAERKRRAQEQ 134
            .::..|.:|:|.|:.|||||.:|||||      |...|:..|::..|...:|..|:....|    
  Fly    66 HIVHACMQGFNGTIFAYGQTSSGKTYT------MMGDEQNPGVMVLAAKEIFQQISSETER---- 120

Human   135 GVAGPEFKVSAQFLELYNEEILDLFDSTRDPDTRHRRSNIKIHEDANGGIYTTGVTSRLIHSQEE 199
                 :|.:...::|:|||:|.||.:.        :..::||||..| ||........:|.|:.:
  Fly   121 -----DFLLRVGYIEIYNEKIYDLLNK--------KNQDLKIHESGN-GIVNVNCEECIITSEVD 171

Human   200 LIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRMCTQPDLVNEAVTGLPDGTPPSSEYET 264
            |::.|..|...||...|.||.:||||||||.| :.:.|.....|  ::||               
  Fly   172 LLRLLCLGNKERTVGETNMNERSSRSHAIFKI-IIESRKSDHSD--DDAV--------------- 218

Human   265 LTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYRDSKLTR 329
            :.:..:.||||||||..:|||.|.|.|||..||..||.|.|||.:|.:.:.. ....||||||||
  Fly   219 IQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADN-RFTNYRDSKLTR 282

Human   330 LLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQ---DKT-----SQQIS 386
            :||.|||||:.|.:|..:.||..:  |:.:||.:|.||:.|:.|..||:   |.|     .::|.
  Fly   283 ILQASLGGNAFTSIICTIKPSIME--ESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIK 345

Human   387 ALRAEIARLQ-------------------------------------------------MELME- 401
            .|:.::|..:                                                 :||.| 
  Fly   346 VLKDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAET 410

Human   402 ------------------------YKAGKR---------VIG--EDGAEGYS------------- 418
                                    ..||||         ::|  :.|.|..|             
  Fly   411 GTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDF 475

Human   419 -----DLFR-------------------------------------------------------E 423
                 |:.:                                                       .
  Fly   476 GSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLA 540

Human   424 NAMLQKENGALRLRVKAMQEAIDAINNRVTQLM--SQEANLLLAKAGDGNEAIGAL--------I 478
            ....|::|  |.....|.:|..||:...||.|.  ::.||   :|..:..|.:..|        :
  Fly   541 EVTAQRDN--LEQESLAEKERYDALEKEVTSLRADNEAAN---SKISELEEKLSTLKQTMRIMEV 600

Human   479 QNYIR----------------EIEELRTKLLESEAMNESLRRSLSR------ASARSPYSLGASP 521
            :|.:.                .:::|.:.|||.|:..|||::||..      .:::..:.|..:|
  Fly   601 ENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAP 665

Human   522 AAPAFGG-------------------------------------SPASSMEDA-----SEVIRRA 544
            ......|                                     ....|:|.|     ||:|::|
  Fly   666 EQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKA 730

Human   545 KQDLERLKKKEVRQRRKSPEKEAF-----KKRAKLQQENSEE---TDENEAEEEEEERDESGCEE 601
             .|.|||.|:      .|..:.||     :..|..||..:::   |..:|..|..:|:.:...||
  Fly   731 -TDCERLSKE------LSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEE 788

Human   602 EEGREDEDEDSGSEE-SLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLK- 664
            .|..|.....:.|.| ..:.:|:      ..||||:|.|...:|..|.::.|::||:..::.|: 
  Fly   789 YEQLESRARSASSAEFQRLQNDN------TKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRI 847

Human   665 --HQYEEKLILLQNKIRDTQLERD----RVLQNLSTMECYTEE---------------------- 701
              |:...|:..|:....:.|.|.|    ::::::...:...||                      
  Fly   848 QNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDF 912

Human   702 -----------------------------------KANKIKADY--------------------- 710
                                               :||::|.|.                     
  Fly   913 DEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQ 977

Human   711 --------------------------------EKRL-------------------------REMN 718
                                            ||||                         .||.
  Fly   978 SDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMR 1042

Human   719 RDLQKLQAAQKEHARLLKNQSRYERELKKLQAEVAEMKKAKVALMKQM-REEQQRRRLVE----- 777
            ..:..|::|..|.:.::.....|:|:::.|:.:.|||......|..:: ||......|:.     
  Fly  1043 EQMTNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDE 1107

Human   778 ----------TKRNREIAQLKKEQRRQEFQIRALESQKRQQEMVLRRKTQEVSALRRLAKPMSER 832
                      ::|.:|:|.||......:.|:..|:::.......::.|...::.|:...:.||||
  Fly  1108 DTLPGCPTSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSER 1172

Human   833 VAGR----AGL------KPPMLDSGAE-------------------------VSASTTSSEAESG 862
            ....    |.|      |..:||..|:                         .:.|.:.::|:..
  Fly  1173 CLSMEVRLAELDEDTKQKQELLDRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPD 1237

Human   863 ARSVSSIVRQWNRKINHFLGD-----HPAPTVNGTR--PARKKF-------QKKGASQSF----- 908
            ...:||.......|:|..|..     |....:....  ..|.:|       :|:..::.:     
  Fly  1238 QILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAELQE 1302

Human   909 ------SKAARLKWQSLERRIIDIVMQRMTIVNLEADMERL-------------------IKKRE 948
                  |..|.||.:.|:   ::..:..:| |..:|::|.|                   ::.:.
  Fly  1303 TKDRYESNVAELKEKLLQ---VEETLSSVT-VRCQAELEALKSAHKENISQAVEERNNLIVQHQA 1363

Human   949 ELFLLQEALRRK--------------------------RERLQAESPEEEKGLQELAEEIEVLAA 987
            |:..::|.|:.|                          .|:|.....:.:||..:|.|..:.|. 
  Fly  1364 EMETIRETLKNKLAEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDRDKGASKLEEVKKTLE- 1427

Human   988 NIDYINDG--ITDCQATIVQLEETKEELD------STDTSVVISSCSLAEARLLLDNFLKASIDK 1044
              ..||.|  ::|   ||.:||:||.|.|      :.|...:...||..:.:|.:::..:..|..
  Fly  1428 --QMINGGRVMSD---TIAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTRDQISF 1487

Human  1045 GLQVAQKEAQIRLLEGRLRQTDMAGSSQNHLL-LDALR-EKAEAHPELQALIYNVQQENGYASTD 1107
            .::...|:.::.:...:.|..::.......:| ||..| ||.....|:|      :..:.::.|.
  Fly  1488 EIEAHIKKLELIVASSKKRIIELEEKCDQQVLELDKCRLEKLSLESEIQ------KANSEHSCTM 1546

Human  1108 EEISEFSE-----GSFSQSFTMKGSTSHDDFKFK----SEPKLSAQMKAVSAE-----------C 1152
            |::.|...     .:.::.......|..:.|.||    .|....||.|.:..:           |
  Fly  1547 EKLQELQAEMKVLSNRNEKEKCDFETKLETFTFKITDLEEVLKEAQHKVILYDDLVSQHERLKIC 1611

Human  1153 LGPPLDISTKNITKSLASL-VEIKEDGVGFSVRDPYYRD-RVSRTVSLPTRGSTFPRQSRATETS 1215
            |....::|: |:.|.:.|| .|:.:...|.|.||....: |.....::..:.:     :.|.:.:
  Fly  1612 LAEANELSS-NLQKKVMSLHTELIDSQKGISSRDVEINELREELKAAMDAKAT-----ASAEQMT 1670

Human  1216 PLTRRKSYDRGQPIRSTDVGFTPPSSPPTRPRNDRNVFSRLTSN------------QSQGSALDK 1268
            .:|:.|..:.                   |..|....|:|..:|            .|.....|.
  Fly  1671 LVTQLKDVEE-------------------RMANQAEKFTREAANLKGSINELLLKLNSMQETKDM 1716

Human  1269 SDDSDSSLSEVLRGIISPVGGAKGARTAPLQCVSMAEGHTKPILCLDATDELLFTGSKDRSCKMW 1333
            .:..:..|.|.||       .::..|       :|.:..:|  :|:...::|:         |:.
  Fly  1717 LESGNEELKEQLR-------NSQNLR-------NMLDEESK--MCISLKEKLV---------KLE 1756

Human  1334 NLVTGQEIAALKGHPNNVVSIKYCSHSGLVFSVSTSYIKVWDIRDSAKC---IRTLTSSGQV 1392
            :..|..| ..|:.:.:.:    |..|:.|...|.....::.::  :.||   ...|.:|.|:
  Fly  1757 DAKTSLE-QQLRDNKSEI----YQRHTELTKEVELGRNRIGEL--TKKCEELCSDLENSDQI 1811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF21BNP_001239029.1 KISc_KIF4 7..371 CDD:276823 121/365 (33%)
KISc 9..377 CDD:214526 123/371 (33%)
Interaction with TRIM3. /evidence=ECO:0000250|UniProtKB:Q9QXL1 400..1099 189/1163 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..538 6/70 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..628 18/84 (21%)
PKK 660..794 CDD:289257 37/291 (13%)
JAKMIP_CC3 678..806 CDD:292653 35/282 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..865 11/69 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 880..906 5/39 (13%)
Prefoldin 954..1102 CDD:298833 37/183 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1194..1251 5/56 (9%)
WD40 1305..1613 CDD:238121 16/91 (18%)
WD40 1306..>1614 CDD:225201 16/90 (18%)
WD 1 1306..1343 6/36 (17%)
WD40 repeat 1312..1346 CDD:293791 6/33 (18%)
WD 2 1346..1384 6/40 (15%)
WD40 repeat 1351..1387 CDD:293791 6/38 (16%)
WD40 repeat 1407..1450 CDD:293791
WD 3 1410..1448
WD 4 1451..1493
WD40 repeat 1456..1500 CDD:293791
WD 5 1502..1539
WD40 repeat 1509..1541 CDD:293791
WD 6 1543..1582
WD40 repeat 1548..1572 CDD:293791
WD 7 1585..1622
cmetNP_524993.3 KISc 8..328 CDD:214526 122/364 (34%)
Motor_domain 8..321 CDD:277568 120/357 (34%)
Smc <680..1449 CDD:224117 133/791 (17%)
TMPIT 779..>867 CDD:285135 23/93 (25%)
Smc 1042..1910 CDD:224117 147/843 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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