DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KIF21B and prp5

DIOPT Version :9

Sequence 1:	NP_001239029.1	Gene:	KIF21B / 23046	HGNCID:	29442	Length:	1637	Species:	Homo sapiens
Sequence 2:	NP_595604.1	Gene:	prp5 / 3361260	PomBaseID:	SPBP22H7.07	Length:	473	Species:	Schizosaccharomyces pombe

Alignment Length:	397	Identity:	89/397 - (22%)
Similarity:	152/397 - (38%)	Gaps:	112/397 - (28%)

- Green bases have known domain annotations that are detailed below.

Human  1255 RLTSNQSQGSALDKSDDSDSSLS--------EVLRGI---ISPVGGAKGA----RT--------- 1295
            |..|.......:.|..|.:..::        |.::|:   ...:.|...|    ||
pombe    85 RADSENPSSQVITKFSDPNKKIAGQVSMQSLEKIKGVPEAAHRIAGESQASLVKRTLAEQIRPEW 149

Human  1296 -APLQCVSMAEGHTKPILCLDAT--DELLFTGSKDRSCKMWNLVTGQEIAALKGHPNNVVSIKYC 1357
             ||...:.:..||...:.|:|..  ::...||:.||:.|:|:|.:|.....|.||...|..:...
pombe   150 HAPWTLMRVISGHLGWVRCVDVEPGNQWFCTGAGDRTIKIWDLASGVLKLTLTGHIATVRGLAVS 214

Human  1358 SHSGLVFSV-STSYIKVWDIRDSAKCIRTLTSSGQVISGDACAATSTRAITSAQGEHQINQIALS 1421
            .....:||. ....:|.||: ::.|.||.....   :||                   :..:.|.
pombe   215 PRHPYLFSCGEDKMVKCWDL-ETNKVIRHYHGH---LSG-------------------VYALKLH 256

Human  1422 PSGTMLYAASGNAV-RIWELSRFQPVGKLTGHIGPVMCLTVTQTASQHDLVVTGSKDHYVKMFEL 1485
            |:..:|..|..:|| |:|::...|.|..|:||...|..|.|.:...|   |||||.|..:::::|
pombe   257 PTLDVLVTAGRDAVARVWDMRTRQNVHVLSGHKSTVASLAVQEFDPQ---VVTGSMDSTIRLWDL 318

Human  1486 --GECVTGTIGPTHNFEPPHYDGIECLAIQGD--ILFSGSRDNGIKKWDLDQQELIQQIPNAHKD 1546
              |:.:| |:  ||     |...:..|::..|  ...|||.|| ||.|         :.|..
pombe   319 AAGKTLT-TL--TH-----HKKTVRALSLHPDEFTFASGSSDN-IKHW---------KFPEG--- 362

Human  1547 WVCALAFIPGRPMLLSACRAGVIKVWNVDNFTPIGEIKGHDSPINAICTNAKHI-FTASSDCRVK 1610
                 ||                          :|..:||::.:|.:..|:.:: |:.:.:..:.
pombe   363 -----AF--------------------------MGNFEGHNAIVNTLSINSDNVMFSGADNGSMC 396

Human  1611 LWNYVPG 1617
            .|::..|
pombe   397 FWDWKSG 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF21B	NP_001239029.1	KISc_KIF4	7..371	CDD:276823
		KISc	9..377	CDD:214526
		Interaction with TRIM3. /evidence=ECO:0000250\|UniProtKB:Q9QXL1	400..1099
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..628
		PKK	660..794	CDD:289257
		JAKMIP_CC3	678..806	CDD:292653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..906
		Prefoldin	954..1102	CDD:298833
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1194..1251
		WD40	1305..1613	CDD:238121	75/316 (24%)
		WD40	1306..>1614	CDD:225201	76/316 (24%)
		WD 1	1306..1343		12/38 (32%)
		WD40 repeat	1312..1346	CDD:293791	11/35 (31%)
		WD 2	1346..1384		9/38 (24%)
		WD40 repeat	1351..1387	CDD:293791	9/36 (25%)
		WD40 repeat	1407..1450	CDD:293791	10/43 (23%)
		WD 3	1410..1448		10/38 (26%)
		WD 4	1451..1493		15/43 (35%)
		WD40 repeat	1456..1500	CDD:293791	16/45 (36%)
		WD 5	1502..1539		11/38 (29%)
		WD40 repeat	1509..1541	CDD:293791	10/33 (30%)
		WD 6	1543..1582		2/38 (5%)
		WD40 repeat	1548..1572	CDD:293791	2/23 (9%)
		WD 7	1585..1622		7/34 (21%)
prp5	NP_595604.1	WD40	<143..402	CDD:225201	78/336 (23%)
		WD40	155..449	CDD:238121	77/327 (24%)
		WD40 repeat	168..203	CDD:293791	11/34 (32%)
		WD40 repeat	209..245	CDD:293791	8/36 (22%)
		WD40 repeat	250..286	CDD:293791	10/35 (29%)
		WD40 repeat	293..328	CDD:293791	13/40 (33%)
		WD40 repeat	334..369	CDD:293791	14/78 (18%)
		WD40 repeat	375..414	CDD:293791	5/29 (17%)
		WD40 repeat	424..448	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910