DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TNIK and ppk11

DIOPT Version :9

Sequence 1:	NP_055843.1	Gene:	TNIK / 23043	HGNCID:	30765	Length:	1360	Species:	Homo sapiens
Sequence 2:	NP_594517.1	Gene:	ppk11 / 2541473	PomBaseID:	SPAC2C4.14c	Length:	312	Species:	Schizosaccharomyces pombe

Alignment Length:	271	Identity:	111/271 - (40%)
Similarity:	164/271 - (60%)	Gaps:	19/271 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    28 VELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEIN-MLKKYSHHRNIATYYGAF 89
            ::|:|.|::|.|::.:.|::.::.|:||  :|.|.|:.|.:.|||| ::...|.|  |..||.:|
pombe     9 LQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVH--ITKYYASF 71

Human    90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDI 154
            :    .|.  :||:.||:|..||..||:|  ...|..|..||.:.|::|..|.:||....:||||
pombe    72 V----DGF--RLWITMEYCDGGSCLDLLK--LSGTFSERVIAEVMRQVLEALVYLHGQGKMHRDI 128

Human   155 KGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSL 219
            |..|:|..::..|||.|||||.||:....:.:.|:|||:||||||:     ....|::|:|:|||
pombe   129 KAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVV-----KQTGYNYKADIWSL 188

Human   220 GITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLM 284
            ||||.|:|.|.||...:|||:.|.|||::..|.|:..|:|:.|..|:.:||.||...|...|.|.
pombe   189 GITAYELATGEPPYSGIHPMKVLLLIPKHSPPSLERSKFSRAFCDFVSNCLKKNPKDRATAEYLS 253

Human   285 KHPFIRDQ-PN 294
            ||.||:.. ||
pombe   254 KHKFIKKYCPN 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNIK	NP_055843.1	STKc_TNIK	18..313	CDD:270807	111/271 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..347		6/12 (50%)
		Mediates interaction with NEDD4. /evidence=ECO:0000269\|PubMed:20159449	290..1047		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..440
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	814..878
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..998
		CNH	1042..1340	CDD:214481
ppk11	NP_594517.1	STKc_MST3_like	4..278	CDD:270786	111/271 (41%)
ppk11	NP_594517.1	S_TKc	6..258	CDD:214567	107/263 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910