DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XPO7 and Ranbp16

DIOPT Version :9

Sequence 1:	NP_001093631.1	Gene:	XPO7 / 23039	HGNCID:	14108	Length:	1096	Species:	Homo sapiens
Sequence 2:	NP_001188596.1	Gene:	Ranbp16 / 118436	FlyBaseID:	FBgn0053180	Length:	1110	Species:	Drosophila melanogaster

Alignment Length:	1091	Identity:	641/1091 - (58%)
Similarity:	824/1091 - (75%)	Gaps:	22/1091 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     8 LAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVS 72
            :.|||.|||||||.||...|.:||||||.|.:|.|.|.||||||:|..|||:|||||:.||||:
  Fly     3 IQQLEVLCKQLYEATDIRIRSEAEKALVTFVSSQDALPKCQLLLQRADSSYAQLLAASTLTKLI- 66

Human    73 RTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDV 137
               ..|.|::|||||:|.||||||.|.|..||.|||:.|.|::||.||||..|::.||:|.:.||
  Fly    67 ---QGLSLQERIDIRSYALNYLATVPNLQHFVVQALVSLLAKLTKYGWFDSYKEEMVFQNLLEDV 128

Human   138 TRFLQDSVEYCIIGVTILSQLTNEINQVSATAFLIEADTTHPLTKHRKIASSFRDSSLFDIFTLS 202
            .:|||.|||:|.|||.|||||..|:|.|      :|.|.....:|.||||:||||..|.:.|.||
  Fly   129 KKFLQGSVEHCTIGVQILSQLVCEMNSV------VEMDVQVSFSKMRKIATSFRDQQLLETFLLS 187

Human   203 CNLLKQA--SGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAF 265
            |:||..|  :.||::..||||..|:..:|:||.|||:|||||:|||||:||:..|||||:||.||
  Fly   188 CSLLVSARDNSKNISFMDESQQALISHVLRLTKNCLSFDFIGSSTDESADDMNNVQIPTAWRPAF 252

Human   266 LDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSL 330
            |||:||:||||||..:|...:...:||||||.|||||||||:||.|||:|||:|||.||.....|
  Fly   253 LDSNTLKLFFDLYQILPNGLASYSISCLVQITSVRRSLFNNSERTKFLTHLVEGVKDILTTLHGL 317

Human   331 SDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQR 395
            |||:|||||||||||||||||||||:.|..|||.|:|||.|||.||..|.||||||||||:||||
  Fly   318 SDPDNYHEFCRLLARLKSNYQLGELIAVPCYPEAIQLIAKFTVESLHLWLFAPNSVHYLLTLWQR 382

Human   396 LAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGR 460
            :.|||||||:.:||:|.||||||.||||.|||::|.:|:||.|:|||:|..:|||||:|||.|.|
  Fly   383 MVASVPYVKSPDPHLLGTYTPEVIKAYIESRLDAVPVIIRDNLDDPLDDFCMVQQQLEQLSVIER 447

Human   461 CEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQ 525
            |||.|||.||||.|||.|:.|:.|||:.:|:.:||.:.|.:|||||||||:.|.||::.|::||.
  Fly   448 CEYNKTCNLLVQHFDQKAREYENLLQTPNANSIDITIHELQLTWLVYIIGSAIVGRLTVATSDEH 512

Human   526 DAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLG 590
            |.||.|||.||||||.|||:||.|||.||||||:|||.:|.||::..:|.||:: |.:|||||.|
  Fly   513 DTMDAELVIRVLQLMTLTDARLPQAGCEKLELAILSFLDQVRKMHSSEQAQKAN-LNKRLSEVFG 576

Human   591 LNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSE 655
            |.||.|:||....|||||||:|||.|.|.:|||.||::||:.::|||||.:|..|||||.:||||
  Fly   577 LTDEQMLLSFINRKIITNLKFWGRSESIITKTLMLLSELSVHFNSVRKLARLEEVQFMLTHHTSE 641

Human   656 HFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQ-MFSTNSF 719
            ||.|||.|  |:|::|||||.|||:||||||.||||||:::..|:.|||..||::.. |...|.|
  Fly   642 HFPFLGTN--SSLSEMRCRTMFYTSLGRLLMFDLGEDEERFYNFLEPLTNQFESLGSVMMDNNIF 704

Human   720 NEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWI-YPSYMPILQRAIELWYHDPACTTPVLKL 783
            :.:|||:.::||.|||||:|...||:..:.|||||: |..|:|||.||::||.||||.|||:|||
  Fly   705 SNEEAKKVIIGLARDLRGLALPLNARIQYTMLFEWLYYADYLPILLRAMDLWAHDPAVTTPILKL 769

Human   784 MAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSML 848
            .|||||.|:|||..:||||.|||||||.||:|.:||||||. .|||::::|.::||||:|||.:|
  Fly   770 FAELVHCRTQRLAGNVSSPMGILLFREASKLICIYGNRILH-QEVPRERLYPMRLKGIAICFLIL 833

Human   849 KAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNF 913
            |.:|.|:|||.|||:|||||.||:.|....||:|:|...||::|||||.:||:||..|:|||:::
  Fly   834 KNSLGGNYVNCGVFKLYGDDTLDSVLNIIAKLILTIEQRDLIEYPKLSTAYYNLLNCLSQDHVSY 898

Human   914 IASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQL----SRSTKKRTTPLNQES 974
            :|:|||...:|||.|:::||.|||:.....||:.||.||:|:||||    |....|:...||||:
  Fly   899 LAALEPAAFVYILKSLTKGLAALDSATYISCCTILDSIVSYIFKQLQMKVSTFPNKKLRSLNQEN 963

Human   975 DRFLHIMQQHPEMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPE 1039
            .:||.:::.:.|::|.|:|::||.::.||||||||||||||.||||.|.|:..|::.|:.:||.|
  Fly   964 VQFLKVVEMNSELLQSMMSSLLNNVLQEDCRNQWSMSRPLLVLILLYEDYYRSLKDRIICAQPIE 1028

Human  1040 KQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVN 1090
            |||.|...|::||.|||||:.:||:::||||:|.|||:|.:..|::..|.:
  Fly  1029 KQQTMAQWFDDLMVGIERNVSSKNKEKFTQNMSTFRRDVVNLPKSTAGGAD 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XPO7	NP_001093631.1	CRM1	29..>314	CDD:227432	166/286 (58%)
XPO7	NP_001093631.1	IBN_N	30..96	CDD:197981	41/65 (63%)
Ranbp16	NP_001188596.1	IBN_N	25..87	CDD:281761	41/65 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159014
Domainoid	1	1.000	1129	1.000	Domainoid score	I19
eggNOG	1	0.900	-	-		E1_KOG1410
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22857
Inparanoid	1	1.050	1240	1.000	Inparanoid score	I183
Isobase	1	0.950	-	0	Normalized mean entropy	S2669
OMA	1	1.010	-	-		QHG53933
OrthoDB	1	1.010	-	-		D198413at2759
OrthoFinder	1	1.000	-	-		FOG0004030
OrthoInspector	1	1.000	-	-		otm41223
orthoMCL	1	0.900	-	-		OOG6_102412
Panther	1	1.100	-	-	LDO	PTHR12596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3705
SonicParanoid	1	1.000	-	-		X2778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750