Protein Alignment WDTC1 and Wdtc1

DIOPT Version :10

• Sequence 1: NP_001263181.1
• Gene: WDTC1 / 23038
• HGNCID: 29175
• Length: 677
• Species: Homo sapiens
• Sequence 2: NP_001101378.1
• Gene: Wdtc1 / 313020
• RGDID: 1310362
• Length: 676
• Species: Rattus norvegicus
• Alignment Length: 677
• Identity: 660/677 - (97%)
• Similarity: 669/677 - (98%)
• Gaps: 1/677 - (0%)

Human     1 MAKVNITRDLIRRQIKERGALSFERRYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKGDLLASG 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MAKVNITRDLIRRQIKERGALSFERRYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKGDLLASG 65

Human    66 SDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHAGDRILITGAADSKVHVHDLTVKETIHMF 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 SDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHAGDRILITGAADSKVHVHDLTVKETIHMF 130

Human   131 GDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGQLVEAKCLTVNPQ 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||.:|||||||||||
  Rat   131 GDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGPMVEAKCLTVNPQ 195

Human   196 DNNCLAVGASGPFVRLYDIRMIHNHRKSMKQSPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLP 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 DNNCLAVGASGPFVRLYDIRMIHNHRKSMKQSPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLP 260

Human   261 DYNNRLRVLVATYVTFSPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSSGEVQNGKMST 325
            |||:||||||||||||||||||||||||||||||||||||||||||||||||||. |||||||||
  Rat   261 DYNSRLRVLVATYVTFSPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSV-EVQNGKMST 324

Human   326 NGVSNGVSNGLHLHSNGFRLPESRGHVSPQVELPPYLERVKQQANEAFACQQWTQAIQLYSKAVQ 390
            |||||||||||||||||||||||:|.:||||||||||||||||||||||||||||||||||||||
  Rat   325 NGVSNGVSNGLHLHSNGFRLPESKGCISPQVELPPYLERVKQQANEAFACQQWTQAIQLYSKAVQ 389

Human   391 RAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALEC 455
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   390 KAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALEC 454

Human   456 LDDFKGKFPEQAHSSACDALGRDITAALFSKNDGEEKKGPGGGAPVRLRSTSRKDSISEDEMVLR 520
            |||||||||||||||||||||||||||||||:||||||..|||.|||||||||||||||||||||
  Rat   455 LDDFKGKFPEQAHSSACDALGRDITAALFSKSDGEEKKAAGGGGPVRLRSTSRKDSISEDEMVLR 519

Human   521 ERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNLVRVLQGDESIVNC 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   520 ERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNLVRVLQGDESIVNC 584

Human   586 LQPHPSYCFLATSGIDPVVRLWNPRPESEDLTGRVVEDMEGASQANQRRMNADPLEVMLLNMGYR 650
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:|||.|||:||||
  Rat   585 LQPHPSYCFLATSGIDPVVRLWNPRPESEDLTGRVVEDMEGASQANQRRMNANPLEAMLLDMGYR 649

Human   651 ITGLSSGGAGASDDEDSSEGQVQCRPS 677
            |||||||||||||||||:|||||||||
  Rat   650 ITGLSSGGAGASDDEDSAEGQVQCRPS 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDTC1	NP_001263181.1	WD40	<39..215	CDD:441893	173/175 (99%)
		WD 1	45..84		38/38 (100%)
		WD40 repeat	51..88	CDD:293791	36/36 (100%)
		WD 2	88..129		40/40 (100%)
		WD40 repeat	93..131	CDD:293791	37/37 (100%)
		WD 3	132..172		39/39 (100%)
		WD40 repeat	138..178	CDD:293791	39/39 (100%)
		WD 4	182..222		37/39 (95%)
		WD40 repeat	232..271	CDD:293791	37/38 (97%)
		WD 5	265..305		39/39 (100%)
		Spy	359..>468	CDD:443119	107/108 (99%)
		TPR 1	362..395		31/32 (97%)
		TPR repeat	366..390	CDD:276809	23/23 (100%)
		TPR repeat	395..428	CDD:276809	32/32 (100%)
		TPR 2	397..432		34/34 (100%)
		TPR repeat	433..457	CDD:276809	23/23 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..509		17/21 (81%)
		WD 6	535..575		39/39 (100%)
		WD40 repeat	537..577	CDD:293791	39/39 (100%)
		WD40	<546..>626	CDD:475233	79/79 (100%)
		WD 7	578..617		38/38 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..677		20/21 (95%)
Wdtc1	NP_001101378.1	WD40	<39..215	CDD:441893	173/175 (99%)
		WD40 repeat	51..88	CDD:293791	36/36 (100%)
		WD40 repeat	93..131	CDD:293791	37/37 (100%)
		WD40 repeat	138..178	CDD:293791	39/39 (100%)
		WD40 repeat	232..271	CDD:293791	37/38 (97%)
		Spy	358..>467	CDD:443119	107/108 (99%)
		TPR repeat	365..389	CDD:276809	23/23 (100%)
		TPR repeat	394..427	CDD:276809	32/32 (100%)
		TPR repeat	432..456	CDD:276809	23/23 (100%)
		WD40 repeat	536..576	CDD:293791	39/39 (100%)
		WD40	<545..>625	CDD:475233	79/79 (100%)