DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment WDTC1 and iqw1

DIOPT Version :10

Sequence 1:NP_001263181.1 Gene:WDTC1 / 23038 HGNCID:29175 Length:677 Species:Homo sapiens
Sequence 2:NP_596313.1 Gene:iqw1 / 2541121 PomBaseID:SPBC609.03 Length:809 Species:Schizosaccharomyces pombe


Alignment Length:843 Identity:198/843 - (23%)
Similarity:315/843 - (37%) Gaps:267/843 - (31%)


- Green bases have known domain annotations that are detailed below.


Human     8 RDLIRRQIKERGALSFERRYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKGDLLASGSDDQHTI 72
            ||..:|:|        .|..:....::..:.|:.||.||:||||.|:|:..|:.|.|||||...|
pombe    14 RDWFQRKI--------SRDIYGNSTWLTGIDLQKELTGHTGCVNTLDWSADGEFLLSGSDDTRLI 70

Human    73 VWDPLHHKK---LLSMHTGHTANIFSVKFLPHAGDRILITGAADSKVHVHDLTVKETIHMFGDH- 133
            |||..:..|   |:|  |||..||||.||:|::.:|.:::.:.|..:.:.||...:...|  || 
pombe    71 VWDVFNEYKPRHLIS--TGHVQNIFSAKFVPYSNNRQILSASGDKLIKLFDLDSSKEGGM--DHG 131

Human   134 -----------TNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSE------VLIDLTEYC 181
                       .:.||.|..... .:||...:|||..||||:||....::      :|::...| 
pombe   132 METQTRCWSCALDSVKNIVPCDN-GHTFLVCSEDGTARQYDIREPHVCNQDLDCPSILVNYNPY- 194

Human   182 GQLVEAKCLTVNPQDNNCLAVGASGPFVRLYDIRMIHNHRKS------MKQSPSAGVHTFCDRQK 240
              .:....:|::|.:....|:|.:.|:..|||.||:   :||      |..||.....  |.| |
pombe   195 --RINLYTITMSPSNPYYFAIGGTHPYAFLYDRRMV---KKSFRDDWTMNTSPEKDCR--CVR-K 251

Human   241 PLPDGAAQYYVAGHLPVKLPDYNNRLRVLVATYVT---FS-PNGTELLVNMGGEQVYLF----DL 297
            ..|||:.                 ..:.::..|:|   || .|..||||:...:.||||    |.
pombe   252 FSPDGSC-----------------NSQGILDRYITCCQFSAANPNELLVSWNSDYVYLFHVHEDK 299

Human   298 TY-----------------------------------------------KQRPYTFLLPRKCHSS 315
            :|                                               .:.|||...||| |:.
pombe   300 SYTPTFNKIEDSNKKPSKPSLLQTQPLKRKNYSPWYKNNFGASTPASRVSRNPYTAAQPRK-HTF 363

Human   316 GEV----------QNGKMSTNGVSNGVS----------NGLHLHSNGFRLPESRGHVSPQVELPP 360
            .::          :||.:..:.||..:|          :.::...|...:|:|.|          
pombe   364 YQMYENIEKFFTTENGGLYESIVSGRLSHFSRSIQYVKDAIYFLENYNYIPDSNG---------- 418

Human   361 YLERVKQQANEAFACQQWTQAIQ---LYSKAVQRAPHNAMLYGNRAAAYMKRKW-------DGDH 415
                 ...:....|.:.|...:.   |....|...| |.::.......|....|       ..||
pombe   419 -----LNHSIRVSALRYWRACVSILALMDDTVSLEP-NTIIQAGWGWLYDFMNWVTRYLLGISDH 477

Human   416 YDALR------------------DCLKAISLNPCH-LKAHFRL-------ARCLFELKYVAEALE 454
            : ||:                  :..:.:..||.. ::|..|:       .|..|.:..|...  
pombe   478 W-ALQMSPPTNVARQNFVLCDPDEPSRVLFSNPSEMIRAFARIDTNDLSSVRRFFWIHKVLRG-- 539

Human   455 CL-----DDFKGKFPEQAHSSACDALGRDITAA--LFSKN----------DGEEKKGPGGGAPVR 502
            ||     |.:..:|      ...|:...|:|::  |..:|          :.|.:.....|..:.
pombe   540 CLLLISSDIYWEQF------QPWDSSTSDVTSSQRLDDENGFLTLLEPPVNYENEVESSSGENIV 598

Human   503 LRSTSRKDSISEDEMVLRERSYDYQF--------------------------------------R 529
            ...|...|...:|:....|.||.|..                                      .
pombe   599 SMYTGHSDLNDDDDDYQDEESYSYASDDDDESDEDSDEGPTLLSLRMKKRKAVEPNVPVNTHVKS 663

Human   530 YCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNLVRVLQGDESIVNCLQPHPSYCF 594
            |.||||..: ||..||:|.|.:|::||||||.||||:|...:::.::.||...||.::.||....
pombe   664 YYGHCNVES-IKNVNFYGQNDEYVMSGSDDGRFFIWDKLNASILAIIHGDSEAVNVIEGHPRCPT 727

Human   595 LATSGIDPVVRLWN-----PRPESEDLTGRVVEDMEGASQANQRRMNADP--LEVMLLNMGYR 650
            ||.||||..|:::|     |...|.:.|....: :...::.|:::.:.|.  ...||.::.||
pombe   728 LAVSGIDSTVKIFNTENTPPSGCSRNHTSNSYK-IIATNEMNRQQGSRDSYITSRMLSHLAYR 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDTC1NP_001263181.1 WD40 <39..215 CDD:441893 66/196 (34%)
WD 1 45..84 21/41 (51%)
WD40 repeat 51..88 CDD:293791 17/39 (44%)
WD 2 88..129 13/40 (33%)
WD40 repeat 93..131 CDD:293791 11/37 (30%)
WD 3 132..172 16/51 (31%)
WD40 repeat 138..178 CDD:293791 14/45 (31%)
WD 4 182..222 10/39 (26%)
WD40 repeat 232..271 CDD:293791 6/38 (16%)
WD 5 265..305 16/94 (17%)
Spy 359..>468 CDD:443119 23/149 (15%)
TPR 1 362..395 5/35 (14%)
TPR repeat 366..390 CDD:276809 3/26 (12%)
TPR repeat 395..428 CDD:276809 7/57 (12%)
TPR 2 397..432 8/59 (14%)
TPR repeat 433..457 CDD:276809 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..509 4/31 (13%)
WD 6 535..575 19/39 (49%)
WD40 repeat 537..577 CDD:293791 18/39 (46%)
WD40 <546..>626 CDD:475233 31/84 (37%)
WD 7 578..617 16/43 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..677
iqw1NP_596313.1 WD40 32..>173 CDD:475233 54/145 (37%)
WD40 repeat 49..87 CDD:293791 17/39 (44%)
WD40 repeat 92..133 CDD:293791 13/42 (31%)
WD40 repeat 139..183 CDD:293791 14/44 (32%)
WD40 repeat 196..230 CDD:293791 10/36 (28%)
WD40 <659..741 CDD:475233 36/82 (44%)
WD40 repeat 679..711 CDD:293791 14/31 (45%)
WD40 repeat 716..742 CDD:293791 11/25 (44%)
WD40 repeat 751..793 CDD:293791 8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.