DRSC/TRiP Functional Genomics Resources

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Protein Alignment WDTC1 and wdtc1

DIOPT Version :10

Sequence 1:NP_001263181.1 Gene:WDTC1 / 23038 HGNCID:29175 Length:677 Species:Homo sapiens
Sequence 2:XP_002934687.2 Gene:wdtc1 / 100493645 XenbaseID:XB-GENE-977179 Length:667 Species:Xenopus tropicalis


Alignment Length:681 Identity:538/681 - (79%)
Similarity:612/681 - (89%) Gaps:18/681 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAKVNITRDLIRRQIKERGALSFERRYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKGDLLASG 65
            ||:|||.:|:|.||||::.||||:|::|||||||||||||||||||:||||||||||||:|||||
 Frog     1 MARVNIAQDIINRQIKDKRALSFQRQHHVTDPFIRRLGLEAELQGHTGCVNCLEWNEKGNLLASG 65

Human    66 SDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHAGDRILITGAADSKVHVHDLTVKETIHMF 130
            |||||.::|||.||||||||||||||||||||||||:|||||||||||:||||||:|.:||:|:|
 Frog    66 SDDQHMMLWDPFHHKKLLSMHTGHTANIFSVKFLPHSGDRILITGAADAKVHVHDITSRETLHVF 130

Human   131 GDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGQLVEAKCLTVNPQ 195
            .:||||||||||||:||||||||.||||||||||||:..||||||||||||||||||||::::||
 Frog   131 SEHTNRVKRIATAPLWPNTFWSAGEDGLIRQYDLRESGTHSEVLIDLTEYCGQLVEAKCVSISPQ 195

Human   196 DNNCLAVGASGPFVRLYDIRMIHNHRKSMKQSPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLP 260
            |||||||||||||||||||||||:|||:::|:.| |:||||.||||:|:||||||||||||||||
 Frog   196 DNNCLAVGASGPFVRLYDIRMIHSHRKNLQQTQS-GIHTFCSRQKPIPEGAAQYYVAGHLPVKLP 259

Human   261 DYNNRLRVLVATYVTFSPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSSGEVQNGKMST 325
            ||||||||||||||||||:|||||||||||||||||||:||||.|||||:..|:||||||||   
 Frog   260 DYNNRLRVLVATYVTFSPDGTELLVNMGGEQVYLFDLTFKQRPCTFLLPKSLHTSGEVQNGK--- 321

Human   326 NGVSNGVSNGLHLHSNGFRLPESRGHVSPQVELPPYLERVKQQANEAFACQQWTQAIQLYSKAVQ 390
                  .:||:||:||||.:.:|| ::....:|||:||:|||:||:|||.|||:|||:|||:|||
 Frog   322 ------TTNGIHLYSNGFCVADSR-NLGAAADLPPHLEKVKQKANDAFARQQWSQAIELYSEAVQ 379

Human   391 RAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALEC 455
            |||.:||||||||||||||||||||||||||||:|::|||.|||||||||||||||.||:|||||
 Frog   380 RAPGSAMLYGNRAAAYMKRKWDGDHYDALRDCLQALALNPAHLKAHFRLARCLFELHYVSEALEC 444

Human   456 LDDFKGKFPEQAHSSACDALGRDITAALFSKNDGEEKKGPGGGAPVRLRSTSRKDSISEDEMVLR 520
            |::||.|||:||.|||||||.|||..|||||||..|.|   .|..|||||..||||:||||::||
 Frog   445 LEEFKVKFPDQARSSACDALDRDIRVALFSKNDSHEDK---KGGSVRLRSGGRKDSLSEDELLLR 506

Human   521 ERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNLVRVLQGDESIVNC 585
            |||.||:.|||||||||||||||:|.|||.|||||||||||||||||:|..|:||||||||||||
 Frog   507 ERSLDYKHRYCGHCNTTTDIKEASFMGSNGQYIVSGSDDGSFFIWEKDTQALIRVLQGDESIVNC 571

Human   586 LQPHPSYCFLATSGIDPVVRLWNPRPESEDLTGRVVEDMEGASQANQRRMNADPLEVMLLNMGYR 650
            |||||:||||||||||||||||:||||||.|..|||:|||||.||||||||||||||||:|||||
 Frog   572 LQPHPTYCFLATSGIDPVVRLWSPRPESEGLDRRVVQDMEGACQANQRRMNADPLEVMLMNMGYR 636

Human   651 ITGLSSGGAG----ASDDEDSSEGQVQCRPS 677
            |||||.||:|    .||||:|:|||||||||
 Frog   637 ITGLSGGGSGNGGAGSDDEESAEGQVQCRPS 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDTC1NP_001263181.1 WD40 <39..215 CDD:441893 151/175 (86%)
WD 1 45..84 32/38 (84%)
WD40 repeat 51..88 CDD:293791 31/36 (86%)
WD 2 88..129 34/40 (85%)
WD40 repeat 93..131 CDD:293791 30/37 (81%)
WD 3 132..172 33/39 (85%)
WD40 repeat 138..178 CDD:293791 34/39 (87%)
WD 4 182..222 34/39 (87%)
WD40 repeat 232..271 CDD:293791 34/38 (89%)
WD 5 265..305 37/39 (95%)
Spy 359..>468 CDD:443119 88/108 (81%)
TPR 1 362..395 25/32 (78%)
TPR repeat 366..390 CDD:276809 17/23 (74%)
TPR repeat 395..428 CDD:276809 29/32 (91%)
TPR 2 397..432 31/34 (91%)
TPR repeat 433..457 CDD:276809 21/23 (91%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..509 10/21 (48%)
WD 6 535..575 32/39 (82%)
WD40 repeat 537..577 CDD:293791 32/39 (82%)
WD40 <546..>626 CDD:475233 67/79 (85%)
WD 7 578..617 35/38 (92%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..677 16/25 (64%)
wdtc1XP_002934687.2 WD40 <39..305 CDD:441893 228/266 (86%)
WD40 repeat 51..87 CDD:293791 30/35 (86%)
WD40 repeat 93..131 CDD:293791 30/37 (81%)
WD40 repeat 137..178 CDD:293791 35/40 (88%)
WD40 repeat 185..212 CDD:293791 22/26 (85%)
WD40 repeat 235..270 CDD:293791 31/34 (91%)
TPR repeat 355..379 CDD:276809 17/23 (74%)
Spy 358..>457 CDD:443119 81/98 (83%)
TPR repeat 384..417 CDD:276809 29/32 (91%)
TPR repeat 422..447 CDD:276809 22/24 (92%)
WD40 <514..594 CDD:475233 70/79 (89%)
WD40 repeat 526..563 CDD:293791 29/36 (81%)

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