DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDZD2 and CG15803

DIOPT Version :9

Sequence 1:	XP_005248326.1	Gene:	PDZD2 / 23037	HGNCID:	18486	Length:	2873	Species:	Homo sapiens
Sequence 2:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	1029	Identity:	217/1029 - (21%)
Similarity:	364/1029 - (35%)	Gaps:	278/1029 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   328 EVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL 392
            |..::..::|:.:.:|||..:.|||.:     .:|:..:..||.|.|||||.|||.||.|....|
  Fly     6 EWSQVEVIDLINDGNGLGFILVGGRST-----GVVIKALTPGGVAERDGRLQLGDHLLQIGEVNL 65

Human   393 VGLSHEEAVAILRSATGMVQLVVASK-ENSAEDLLRLTSKS--LP-DLTSSVEDVSSWTDNEDQE 453
            .|.|.|:...:||.....|:|:||.. |.:|.|...|..::  :| .|.|..|::|.........
  Fly    66 RGFSSEQVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSF 130

Human   454 ADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLE----------SPKQGSNKIKLKSRLSGG 508
            |....   .:::...|..|:....||.|.    |.|:          .|.:|:....::.:.|..
  Fly   131 ATAAV---AAAAAAAAAAGSGSDGDVGGG----GVLDVASLVGLVRGGPAEGTELSAVEPQPSAA 188

Human   509 VHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQE-----------YHIVKK 562
            |.:|:.:.|.      .||.....|.....|..||   ::..|:|.|.           :.|:..
  Fly   189 VLQLQQLSEL------AGDLADFPLPPIPGGGGHS---MVTDSNAGQRPCPRLDLDIVPFSILSP 244

Human   563 STR-SLSTTQVESPWRLIR------PSVIS----------------------------------- 585
            ..| :|....:|:.||.::      .:||:
  Fly   245 PPRPALQMLPLETQWRCVQDQNRHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETY 309

Human   586 IIGLYKEKGKGLGFSIAGGRDCIRGQM-GIFVKTIFPNGSAAE-DGRLKEGDEILDVNGIPIKGL 648
            ::.|:|.. .|||.::| |..|....: |||||:|. .||||| .|:::..|.|:.|:|..:.|:
  Fly   310 VVELHKNV-YGLGITVA-GYVCEEEDLSGIFVKSII-EGSAAETSGQIQINDRIVAVDGRSLSGV 371

Human   649 TFQEAIHTFKQIRSGLFV-LTVRTKL-------VSPSLTP---CSTPTHMSRSASPNFNTSGGAS 702
            |..:|:...:  .:.:.| ||:...|       :..:||.   .|.|:.:.||..
  Fly   372 TNHQAVELLR--NTDIVVHLTLERFLRGRKYEHLQVALTEIKGTSAPSGLDRSQD---------- 424

Human   703 AGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAK 767
               .|:...|.|  ..||                               .|.|...|..|.....
  Fly   425 ---KDQDQESQL--SMPG-------------------------------SPSIATLSWLPPKSLD 453

Human   768 MESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTY 832
            .:|..:.||:.::...|.:..|....:..                 |:....|..|..|:.||.:
  Fly   454 ADSIATEGDEAVDAEYVGISGAEDEFIEL-----------------PSRDTVESNMSHVLDRSDH 501

Human   833 QESKEANSSPGLGTPLKSP--SLAKKDSLISESELSQYFAHDVPGPLSDFMVA--GSEDE----- 888
            ......:..|.:     ||  .|....|||...:...........|.::...|  ||:.|
  Fly   502 SGGLTKDQVPRI-----SPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERVK 561

Human   889 DHPGSGCSTSEEGSLPPS---TSTHKEPGK---PRANSLVTLGSHRASGLFHKQVTVARQASLPG 947
            |...:...|..:..|.|.   |.|::.|.|   |.|.||..........|   :.||..:..:..
  Fly   562 DLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRVAWKSLGISL---EGTVDVECGIEK 623

Human   948 SPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCI------SLPGALPGPIRPLSEDDPRRVSI 1006
            .|......:|....||         .:...|.||.:      .|.|.....:..:.::.|.||.:
  Fly   624 RPHHYIRSILADGPVG---------RQGILRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKL 679

Human  1007 SSSKGM---DVHNQEERPRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASY---AANLTDSAEA 1065
            ..::|.   .|.|..:.| :...::::   |.|....|:..:.:...:::.|   .|.|||:..|
  Fly   680 VCARGTHVPSVINTSQNP-EAFETRSL---LPGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAA 740

Human  1066 PKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSP---- 1126
            ..||.|                                       :.|.|:|.:.:..||.
  Fly   741 AGGSGG---------------------------------------TAGGGARSKSLENVSGLALW 766

Human  1127 HCKRSEAEAKPS----GSQTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTT 1187
            .|:.:..:.:.:    |...::.    .||.|.:..|      :.:.|...|||.  |:..::..
  Fly   767 SCEVTAVDIEKTEQGFGFSILDY----QDPLDSEGSV------IVIRGLIRGGAA--EATNEIYP 819

Human  1188 GDACVSTSCELASALSHLDASHLTENLPKAASELG-QQPMTELDSSSDL-ISSP 1239
            ||..:|....|...|...:|..:.:.:|...:.|| .:|::..||:|:. |:||
  Fly   820 GDRLMSVGDRLLQGLELDEAVSILKAMPPGLTRLGICRPLSASDSNSNSNIASP 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492	30/80 (38%)
		PDZ_signaling	589..670	CDD:238492	30/83 (36%)
		PDZ_signaling	726..810	CDD:238492	9/83 (11%)
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	29/76 (38%)
		PDZ	307..393	CDD:214570	30/90 (33%)
		PDZ_signaling	605..680	CDD:238492	15/86 (17%)
		PDZ	773..858	CDD:214570	19/96 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4782
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860