Protein Alignment PDZD2 and bbg

DIOPT Version :9

• Sequence 1: XP_005248326.1
• Gene: PDZD2 / 23037
• HGNCID: 18486
• Length: 2873
• Species: Homo sapiens
• Sequence 2: NP_001246755.1
• Gene: bbg / 39583
• FlyBaseID: FBgn0087007
• Length: 2637
• Species: Drosophila melanogaster
• Alignment Length: 2839
• Identity: 577/2839 - (20%)
• Similarity: 934/2839 - (32%)
• Gaps: 959/2839 - (33%)

Human   707 DEGSSSSLGRKTPGPKDRIVMEVTLNKEP--RVGLGI----GACCLALENSPPGIYIHSLAPGSV 765
            |.||.||     |..:::| ..||:.:.|  |:|.|:    |.....|...   :||.|.|..|.
  Fly    74 DVGSGSS-----PTMEEQI-ENVTVFRLPGERLGFGLKFQGGTRSTELVQK---LYIQSCAADSP 129

Human   766 AKMES----NLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVI----GRHPNPKVSEQE 822
            |...|    ||..||:|:.::..:||.  |:::..:........::||:    |:.|..:...|:
  Fly   130 ASKVSTSWGNLREGDEIVSIDGRDVRE--LTRIDCVRGLKDNVAIKLVVRNGHGQKPPSEEDPQQ 192

Human   823 MDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDS-------LISESEL-----SQYFAHDVPG 875
            .:.:        |...|:.|....|:....|.::.:       |:.|..|     ::|:.:
  Fly   193 QEHL--------SITLNAQPPPPPPVPPRKLVRRQNSKENQAQLLIEKPLTPPPDAEYYLN---- 245

Human   876 PLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVA 940
            .|::.:.||||.:|...:..:..::.|:..:.|:..           :|..|..:.:. :..|:.
  Fly   246 LLTESIKAGSESDDTASTISTVIDKFSVGSNYSSDS-----------SLNGHELAKVL-QPFTLL 298

Human   941 RQASLP-----GSPQAL------RNPLLRQRKVGCYDANDASDEEEF-------------DREGD 981
            .|..||     |.|:.|      .|...:..||..|:..:....|..             .::..
  Fly   299 EQEFLPLEQPLGHPKLLIPGNNYENVEFKTEKVNVYENVELRSPETTPTPKPRVQLATVEPKKRS 363

Human   982 CISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEESIP 1046
            .|.:|..:|.|.:...|..|.||.|........:|:.:.| ||..::...:|:..:      .||
  Fly   364 IIPMPRKIPTPTKLPIEVTPPRVPILEEPKTPTNNKVDSP-KTPTNELKESPISAT------KIP 421

Human  1047 EGMVDAASYAANLTDSAEAPK-GSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSPSS---- 1106
            :.....|.....:.....||| .||.|   |......|.|..:.||.... |||..|:|.|
  Fly   422 KAKFSRAKTEGEIKLHLPAPKQQSPQS---KSRIPIVSTPTAQKTVPKPV-SPTMNGTPLSSNIP 482

Human  1107 ---PQQKSE-----------GLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDS 1157
               .:||||           ...|..||     |..:.:.|||.......|.|.|.:.....|:|
  Fly   483 RLLQKQKSETDLKLNLYRSKSKESSPRP-----PLQRANSAEAPERTFIPVLLNGNSKSSNSLES 542

Human  1158 RVQATSVKVTVAG---FQPGGAVEK-----ESLGKLTTGDACVSTSCELASALSHLDASHLT--E 1212
               .:|:..:.:|   ..|.|...|     :||.|               :.:..|.|...|  :
  Fly   543 ---VSSIGSSSSGNSVRSPKGPKPKPPERVQSLQK---------------TQIPKLQALPTTPPQ 589

Human  1213 NLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKCK 1277
            .:||.:.:..:|             ||       |.|..|.|.|        || |.|.|..:.|
  Fly   590 QIPKLSMQTFKQ-------------SP-------PTPRSTPVGT--------PS-PTSNREIRFK 625

Human  1278 ARSPVRLPHEGSPSPGEKA--------AAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMT 1334
            .::     :|......:|.        :...|..|.|.:....| ||:  :.||..|. .||
  Fly   626 IQT-----YESKTQDEDKLPSLFDLVHSQENDKDKDRDSDSLKT-HNS--ITALLAAA-AAE--- 678

Human  1335 PAGAVLPGDPLTSQEQRQGAP----GNHSKALE---MTGIHAPESSQE----------------- 1375
                       .:...|:..|    |...|.::   .|..:...||.|
  Fly   679 -----------AADLSRESPPPLVVGKCMKIVDDTNTTTCYTSSSSGEEDEDDLDASNREYICED 732

Human  1376 ------PSLLEGADSVSSRAPQASL-------SMLPSTDNTKEACGHVSGHCCPGG-------SR 1420
                  |.|:.|.      .|..:.       :|||:....:|....:.......|       |:
  Fly   733 GEKLGPPELINGP------GPSEAYFNMFWHSNMLPTIGEVEEEFSSLEPQSLTNGNLVKSEESK 791

Human  1421 ESPVTDI---------DSFIKELDASAARS------PSSQTGD-SGSQEGSAQGH---------- 1459
            :.|..::         |..|.:.||||.|:      .::||.: |.|...|.:..
  Fly   792 KLPKMEVNAGGLAQLTDDKIADHDASATRADTRDEVTTNQTQEISSSSSSSVKSQKTTTTTRVTT 856

Human  1460 -PPAGAGGGSSCRAEPVP------------GGQTSSP-------RRAWAAGAPAYPQWASQPSVL 1504
             ..:.:...|||.:..:|            ....|.|       ||..:.     .:..|:....
  Fly   857 TKTSSSSSSSSCSSTVIPDVAFKLQPYEERDDILSEPITTIHEERRVLSE-----QKTLSESRTR 916

Human  1505 DSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAP 1569
            |::..::....:.|..|:.:| |.....:...|.             .||.:|....|.:.|...
  Fly   917 DALTGEEQLVTSANSKSSSAR-FKKISSNDNLLD-------------LGDEQDMQEQPLTATITQ 967

Human  1570 RASAR-------DGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPAS 1627
            .:|.|       |..|..|..::|.:.....||:|.:                   |....|..|
  Fly   968 ESSLRERLECPQDNQSIDRGTLTLSERGKQLSEKEGL-------------------TTYTECETS 1013

Human  1628 AKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSC 1692
            .|          ||....::......|..:...:|.||:...|:|    ||...::..:......
  Fly  1014 EK----------ESYLEGQQVLNGKGGFVSQDENSDQPTYEREVS----ETLTIVNDGEKQVTKK 1064

Human  1693 AEETTEVTSASSAM------ENSPLSKVARHFHSPPIILSSPNMVNGLEH----DLLDDETLNQY 1747
            .|:..|:.....|.      |...|.:.|:     .:|.|...:....|.    :|.||:
  Fly  1065 LEQNKEIAGKKGAKLLKKTDEERRLEQEAQ-----KLIESYQKVKKEAEKLYKLELADDD----- 1119

Human  1748 ETSINAAASLSSF----SVDVPKNGESVLENLHISESQ------DLDDLLQKPKMIARRPIMAWF 1802
                 ....||:|    ..|.|:..|.:.|   :.:||      .:::.::.|..:...   ...
  Fly  1120 -----QGFDLSAFEQAEEEDKPEVSEEIKE---VKDSQPVKVDIQIEEEVKTPNQVIGE---VKV 1173

Human  1803 KEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLS--- 1864
            :::||..:.|                     :|:.....||.|.|.|...:.....|.||.|
  Fly  1174 EDVNKEIKET---------------------VQVSQQEIKKEVKVSHQETKETFKSEEKDESNEL 1217

Human  1865 KKSPAEMLLTNGQKAKCGPKLKRLS--------LKGKAKV---NSEAPAANAVKAGGTDHRK--- 1915
            |....|:.:|:....:...:::.:.        :|..|||   .|...|...|.....||:.
  Fly  1218 KIVKEEVKVTHQDLREQIQEIEAVKVVHKEVKVIKESAKVTTTTSHKQATKEVIISKEDHKNDSA 1282

Human  1916 -PLISPQTSHKTLSKAVSQRLHVADHED---PDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSD 1976
             |.:| .|..:.:|..:...|....|:.   |......|| :|....:.|||:.|:.|..|.
  Fly  1283 LPAVS-TTKVEIISPPLEDDLGYVLHKHIIFPQEKVKTAP-TPLPKPKPKPPVPTNKPKMPV--- 1342

Human  1977 TSIRTFVSPLTSPKPVPEQGMWSRFHMAVLS----EPD----RGCPTTPKSPK----------CR 2023
                ....|.::|.|||.:       .:.||    :|.    ||...|.:.||          .|
  Fly  1343 ----NLTKPKSAPPPVPSK-------RSELSGSGGKPTPTQRRGSLETAQPPKPLERIIVGVEQR 1396

Human  2024 AEGRAPRADSGPVSPAASRNGMSVAGNRQ--------------SEPRLASHVAADTAQPRPTGEK 2074
            .|...|:    |:...||.:..:||.|.:              .|.:..||...|..:.    ||
  Fly  1397 DEPEKPQ----PIINLASVDLPNVAPNSKQATVETTPVVEMPPDELQFESHQLPDDGEK----EK 1453

Human  2075 GGNIMASDRLERTNQLKI-------VEISA-------EAVSETVCG-----NKPAESDRRGGCLA 2120
            ..:..::|.|..::...:       :.:||       ::|.|.|.|     |:..:.|......|
  Fly  1454 DLHQESNDLLSGSSSSSVTTPITTPILVSATSSMDSVQSVIEVVNGMPIISNQQTDDDDIDEVAA 1518

Human  2121 --QGNCQEKSEIRLYRQVAESST-----SHPS---SLPSHASQAEQ----EMSRSFSMAKLASSS 2171
              .|...|....:..|.|.|.:|     .|.|   :|.:|.|....    ..|.:...|.|.|||
  Fly  1519 YDDGMHLEAEGTKDVRPVQEVTTLTLDREHESDLGTLSNHHSNISSISGINASSNIPAATLISSS 1583

Human  2172 ---SSLQTAIRKAEYSQ--GKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRT--------- 2222
               :|.:.|..|....|  ||..|:|.:.|....:    .:...||:    .||.|
  Fly  1584 IKKTSTEAATTKPAAPQIPGKMELLSSNTGTTTTT----TTATHHLH----QATTTKQLLVQDYL 1640

Human  2223 -YSMPAQFSSHFGREGH--PP----------HSL-------------GRSRDSQVPVTS------ 2255
             |:.|..: |....:||  ||          |.|             |:...|..|:..
  Fly  1641 SYASPPTY-SRLPPDGHEFPPNFSEPLIMHSHPLKVTTELSYEIQKGGKDESSAPPLPKTGPPAT 1704

Human  2256 ------------SVVPEAKASRGGLPSLANG---------QGIYSVKPLLDTSRNLPATDEGDII 2299
                        :|.|....:|....||:.|         :...|.|.:.|......:.:|.|.|
  Fly  1705 VPRKVYRQDLVINVEPAPSLTRDYQRSLSGGTPRKPSDWRKDEKSEKSVRDKIAMFSSNNELDAI 1769

Human  2300 SVQETSCLVTDKIKVTRR----------HYCYEQNWPHESTSFFSVKQRIKSFENLAN------- 2347
            .....:..::...  ||:          ..|       .|:|..|:|.|..|.|||.:
  Fly  1770 PPAPATAPISSSF--TRKPLNRSSENLLDSC-------SSSSAPSLKTRAMSVENLNDVQRQYQL 1825

Human  2348 ---------ADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSL-------GHPGDAAARLL--- 2393
                     ||...:.:.|:|..|.:|.|   |||.|...|..:       |..||||.|..
  Fly  1826 AKQLPQLHVADSMYSLNTATPTPSYASLP---RRSHGGSYSSGVERRISFSGEGGDAANRKAAIT 1887

Human  2394 ------RRSLS-----------------------------SCSENQSEAG--------------- 2408
                  |||||                             :..|:.:::|
  Fly  1888 NILEQRRRSLSKLRGLVIPERPQLLEPILDLPEIKSQVKAASGEDSTDSGLGESHRSTVNRNCQL 1952

Human  2409 -----------------------------------TLLP----------------QMAKSPSIMT 2422
                                               :|.|                |.:.:.|:.:
  Fly  1953 GAGGAANNYRSILNTNQRRPLEQQLSQPPAKPPRTSLTPLQPRSMMIPPPPPPLDQESDTDSVFS 2017

Human  2423 LTISRQNPPE----------------------TSSKGSDSELKKSLGPLGIPTPTMTLASPVKRN 2465
            .|.....|||                      |.:.||.:..:.|...|| .||.:.|...|.::
  Fly  2018 HTARVATPPEKFALTRTLSSETNTSIASSNTSTLTSGSSAGSQASCSSLG-STPAVDLTRRVLKS 2081

Human  2466 K----------------------------------------SSVRHTQPSPVSRSKLQELRALSM 2490
            :                                        .|:.:.:..|:|..|||:.:....
  Fly  2082 QVINGEAVALSSRKSILASAKCRSAKSRGQEEDNDSTDGEACSLANRRMKPISSYKLQQQQIQLG 2146

Human  2491 PDL--DKLCSEDYSAGPSAVLFKTELEITPRRSPGP---PAGGVSCPEKGGNRACPGGSG----- 2545
            ..|  |||.:.     .:.|...::.:.:.|||..|   .|..:....|...:..|....
  Fly  2147 KQLVVDKLINV-----AAYVELTSDTDDSSRRSDTPAKISAMFIDEERKASFKGDPNQQAKVKVE 2206

Human  2546 ---PKT------SAAETPSSASDTGE---------AAQ--------------DLPFRRSWSVNLD 2578
               |..      ||...|.....|.|         |||              ..|....:| :||
  Fly  2207 QVKPMVLPMLLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSPVIHKVTQKPHHERFS-SLD 2270

Human  2579 QLL-VSAGDQQRLQSV------------LSSVGSKSTILT------LIQEAKAQSENEEDVCFIV 2624
            .|. .|:|.....|:|            .||:||..:::|      :::||....:..|  .||:
  Fly  2271 SLASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQSLITAQDVQQIVEEADPPLKTPE--AFII 2333

Human  2625 LNRKEG--SGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687
            :.::|.  |.:|.::|||:|.|.|.||:|::.|...|:::|.:.:||.:|:|||.|:.||.|...
  Fly  2334 VLQRENPESSIGITLAGGSDYEAKEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRES 2398

Human  2688 LKVLHQAQ-------LHKDALVVIKKGMDQPRP-----SARQEPPT------------------- 2721
            :.||...:       ...::|||  |.:.:.|.     |:..|.||
  Fly  2399 ISVLKTPRPEVVLVVTRSESLVV--KALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDL 2461

Human  2722 -----ANGKGLLSRKTIPLEPGI-------------ENTEQRMQVQQQHSQEGSPRIGRPTVLLG 2768
                 :|..|.....|.|....:             |.|...::.::|.|:..:.::. .:.||.
  Fly  2462 DLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLS-TSELLE 2525

Human  2769 SSAVIRRSVAVH-------------DALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGG 2820
            .:|..|.::|..             .|.|||::|.|.|||.|::||..|..|:.||::|:|:.||
  Fly  2526 RAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLGNRPLIVKKVFMGG 2590

Human  2821 AAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQL 2864
            ||::...:..|||||:|||.....:...||||.||.:|.|||::
  Fly  2591 AAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQLPLGPVKI 2634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	589..670	CDD:238492
		PDZ_signaling	726..810	CDD:238492	24/93 (26%)
		PDZ_signaling	2623..2694	CDD:238492	28/72 (39%)
		PDZ	2785..2867	CDD:214570	38/80 (48%)
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492	25/91 (27%)
		ATP-synt_B	<1084..>1109	CDD:304375	5/29 (17%)
		PDZ_signaling	2331..2413	CDD:238492	29/81 (36%)
		PDZ_signaling	2553..2634	CDD:238492	39/80 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9725
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11324
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.000