Protein Alignment DOP1A and CG15099

DIOPT Version :9

• Sequence 1: XP_016866048.1
• Gene: DOP1A / 23033
• HGNCID: 21194
• Length: 2485
• Species: Homo sapiens
• Sequence 2: NP_001261081.1
• Gene: CG15099 / 37176
• FlyBaseID: FBgn0034400
• Length: 2683
• Species: Drosophila melanogaster
• Alignment Length: 2870
• Identity: 894/2870 - (31%)
• Similarity: 1402/2870 - (48%)
• Gaps: 681/2870 - (23%)

Human     4 EELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKKLTIGKRLA 68
            ||.:|::::|||.|:..|||||:||||||||||||||||||:|.:.:|.:|||:|::|.|.||||
  Fly     9 EEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLA 73

Human    69 QCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMSVKPTLLSLYEIYY 133
            ||:|||||.|||.||||||.:||...||:|||.: |:||:||||||..|||:|:|.||::||.|:
  Fly    74 QCMHPALPSGVHLKALETYSVIFSKTGPERLATE-FIYSAGLFPLLGYAAMNVRPALLAIYETYF 137

Human   134 LPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSAFYSALWGSLLTSPAVRLP 198
            :|||..|:|.|.|.|.|:|||.:.|.:::||.:.||::|..||:...||:.||.|:..:.|:|||
  Fly   138 VPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLP 202

Human   199 GITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSVLVQRSTLDLILFCFPFHMSQATR 263
            .|||:|.|.|::|.|::|:||:|.:.|:|:.|:...:.||.:||||:||:.:|..||.|....:.
  Fly   203 AITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVLLSE 267

Human   264 PDMIRILSAALHVVLRRDMSLNRRLYAWLLGFD--NNGAIIGPRSTRHSNP--EEHATYYFTTFS 324
            .|::::::..|:.:|||||||||||::||||.:  .|.......|...||.  ||....||...|
  Fly   268 DDLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEPEPYFVKHS 332

Human   325 KELLVQAMVGILQVNGFGEENTLMQDLKPFRILISLLDKPELGPVILEDVLIEVFRTLYSQCKAE 389
            :.:|::|::..|:::    ......||||:||::|||||.|:|..:|:.||.::.|.:|
  Fly   333 RHILIKALITTLRLS----LECAPMDLKPYRIMLSLLDKAEIGSAVLDYVLHDIIRAMY------ 387

Human   390 LDLQTEPPFSKDHAQLSSKLRENKKTAELIKTANLLFNSFEPYYMWDYVARWFEECCRRTLHVRL 454
                           :||      ..||.:|:|||||.:|:|.|:|.|:...||:.|::...::.
  Fly   388 ---------------ISS------GNAEALKSANLLFATFDPAYIWSYMTNMFEKACQQANSMQE 431

Human   455 QIGPGD----------SNDSSELQLTNFCLLVDFLLDIVSLPTRSMRVLCQETYIEIQTEHLPQL 509
            :...|:          |.|...|::   |:|.:|||:.|||          |.|.|....:||::
  Fly   432 KSQAGETSGKYACDVGSGDPCVLEI---CVLTEFLLETVSL----------EMYTETTRVYLPKV 483

Human   510 LLRMISALTSHLQTLHLSELTDSLRLCSKILSKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKV 574
            .|.:...|:.|:..:..:|:|.||:||.||:|:|||.:.|......|...||.::|     |:|:
  Fly   484 FLAITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSS-----DEKI 543

Human   575 --SSVSHENPTEVFEDGENPPSSRSSE--SGFTEFIQYQAD------------------------ 611
              :|.|....||....|.:...|:|..  :.|.|...:.||
  Fly   544 TMNSASDAGKTEAGAQGNSLEKSKSDSRLNQFAENTLHSADPNDEELIHRSASNQSVGRQSPNKK 608

Human   612 ------RTDDIDRELS---EGQGAAAIPIGSTSSETETASTV-------------------GSEE 648
                  |..::|:::|   .||        .:||:.:|..::                   ..:.
  Fly   609 KAKSISRLSELDKDISASDTGQ--------QSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDM 665

Human   649 TIIQ--TPSVVTQGTAT------------------RSRKTAQK--TAMQCCLE----YVQQFLTR 687
            .:||  |.:.|:.|.:.                  .||.|.|:  :.::.|:.    :.:.:|:|
  Fly   666 VLIQSNTSAEVSDGPSAEEPKSAPPDQTPQFQLDEESRATQQRGFSILEKCIRQYEIFFEVYLSR 730

Human   688 LINLYI----------IQ----------NNSFSQSLATEHQGDLGREQGE--------------- 717
            .: |:|          :|          :|.|......:|:..:...|.|
  Fly   731 KL-LHIESEPKECSVKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSK 794

Human   718 -------------TSKWDRNSQGDVKE----------------KNISKQKTSKEYLSAFLAACQL 753
                         .|..:.:|..:.:|                :.:::.:.|.....|...|..|
  Fly   795 QLQRLLNRSLPLPASASELSSDSEAQEEKQQSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATL 859

Human   754 FLECSSFPVYIAEGNHTSELRSEKLETDCEHVQPPQWLQTL-MNACSQASDFSVQSVAISLVMDL 817
            .:|.|:||      |....:..:|.|.:.     |.||:.| :.||...||..:|..:|:.:.||
  Fly   860 LVEMSTFP------NCNKHVVLDKNEPEL-----PNWLKVLCLVACFAQSDKELQVASITTLFDL 913

Human   818 VGLTQSVAMVTGENINSVEPAQPLSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQL 882
            :.|.:|          .:|  ...||  |...||:.|.|..|::.|:.:.|..|:.|:..|||.|
  Fly   914 ISLLRS----------QIE--HTTSP--GVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWDYL 964

Human   883 GDGTPQHHQKSVELFYQLHNLVPSSSICEDVI-----SQQL------------------------ 918
            |.......|.:. |.:|||:.: .|.:.|.||     ||.|
  Fly   965 GTAGIDPAQIAA-LLHQLHSCL-ESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQMERL 1027

Human   919 --------THKDKKIRMEAHA----KFAVLWHLTRDLHINKSSSFVRSFDRSLFIMLDSLNSLDG 971
                    |...:::| |:.|    ||.:||||.||      ....|.|:::|..:||:| :|..
  Fly  1028 AEAQLLCPTESTERLR-ESQARSFKKFELLWHLGRD------KQTARGFEKTLLKVLDTL-ALPH 1084

Human   972 --STSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYWNKSPCYPGEESDKH 1034
              |..:....||...|.|.|:||:.:||..:||...::||.:..:|.....:::...|..|.|.:
  Fly  1085 YMSERTFVTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQLYRESETEVTPAFERDVY 1149

Human  1035 FMQNFACSNVSQVQLITSKGNGEK-PLTMDEIENFSLTV---------NPLSDRLSLLSTSSE-- 1087
            .:.: ...||....:.||.||.:| |:.....:.|.:|:         |.:||: |.::|.||
  Fly  1150 AISS-EQGNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDK-STVATCSEAT 1212

Human  1088 ----TIPMVV------SDF----DLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQ 1138
                ||.:::      :||    ||.:.:|||              .:....::.:..:|.::|:
  Fly  1213 QDMNTIGLIINPLENANDFDDETDLEEPRIEI--------------PHKETPLEQKLASAMDESE 1263

Human  1139 MPKE----SSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDD 1199
            .|.:    :.||:.:|   :|        .::...|.:|..|        ||.:..|.:|: ::|
  Fly  1264 QPSQEQPANQPDNSLQ---YD--------QDITDHSDSSDFE--------SDSELRETSIE-KED 1308

Human  1200 SIQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTL------HDSSVASIET 1258
            ||..|.:|.:|::..:|:     |..|.|.:.::::....  |..|:.|      .::|:.|:|
  Fly  1309 SITVSSSAGVSDDVKRFV-----GDCESVTDALTQHEKIK--SRKTYRLTREKTPGENSLNSLE- 1365

Human  1259 KSRQRSHSSIQ------------FSFKEKLSEK--------------VSEKETIVKESGK----- 1292
               |:.|.||.            |...:||.::              :|:..|....||.
  Fly  1366 ---QKDHDSISELQADALPADEYFREDKKLGKRKKVLTSGEKKRLSCISKTSTDSNISGSHVEQP 1427

Human  1293 ------QPGAKPKVKLARKKDD----------------DKKKSSNEKLKQTSVFFSDGLDLENWY 1335
                  :||.:..:.:..|:.:                :|.|.:.|.|:|.:...:...     .
  Fly  1428 EQEEETEPGTESTINVEDKRRNLSLETSKLQPDMQKTLEKGKQNVEILRQNNAAAAAAA-----A 1487

Human  1336 SCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSRTLYAFSAIKAILKTNPIAFV 1400
            :..|..|| :.|.|.|..|....   .|..:.|:|:||.:||:.:||||...::.|:..:...|:
  Fly  1488 AAAEEQIS-VRSSMKSTVSLTDA---AHLYHNHLLIYLAIYDTRQTLYALQTLRNIICCDKRTFL 1548

Human  1401 NAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIPVDSNH--NFRSSMYIEILISLCLYY 1463
            ....|||.::|      .|:.||.|||.|:.||.|...:. :|.:  .:|..|.:|:|::|||:|
  Fly  1549 CLSITTSFSSA------SLKQLLVRHRKSISGKGFDGSVG-NSEYAQGYRGCMQLELLVTLCLFY 1606

Human  1464 MRSHY------PTHVKVTAQDLIGNRNMQMMSIEILTLLFTELAKVIESSAKGFPSFISDMLSKC 1522
            .|.::      ......|.||::.||.:|:.|||:|||:.:||.::::...:|..::|:|:|::.
  Fly  1607 ARGYFQKESLDAQRQSPTLQDIVNNRRIQLESIELLTLICSELIEIVKGMGRGLANYIADLLARA 1671

Human  1523 KVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFSEDSLINFSEDEFD--NGSTLQSQLLKV 1585
            |:|||:||||.||:.      |..:.|.    ...|...:.:::|::.:.|  :....|.|||::
  Fly  1672 KLQKVMLHCLNSSVC------SYGLKGN----TNSGSYAEQVLSFNDPQDDQLHADCFQLQLLRL 1726

Human  1586 LQRLIVLEHRVMTIPEEN--ETGFDFVVSDLEHISPHQ----PMTSLQYLHAQPITCQGMFLCAV 1644
            |..:|.|||.|..:.::.  ..|.|    ...:.||.:    ...:::||....|:.|.|||.||
  Fly  1727 LLAVIRLEHEVHQLRQDTPPAAGED----SAGNASPTRLAEGATANVKYLPNCLISQQPMFLAAV 1787

Human  1645 IRALHQHCACKMHPQWIGLITSTLP-YMGKVLQRVVVSVTLQLCRNLDNLIQQYKYETGLSDSRP 1708
            :.||.|.....:|..|..|:||:|. :....|..:|:||..|||.|||.:.:.     ||...|.
  Fly  1788 LGALQQERLRHLHRNWTDLVTSSLNCFSFGSLTNIVISVVHQLCSNLDRISKM-----GLPQQRH 1847

Human  1709 LWMASIIPPDMILTLLEGITAIIHYCLLDPTTQ---YH-------------------QLLVSVDQ 1751
                  .|||.:::.||.:|.:.||||||.|.|   .|                   |||.|:
  Fly  1848 ------FPPDYVVSQLEALTILCHYCLLDNTQQTALSHLFNQAYPQTSSSAQSSSTGQLLNSI-- 1904

Human  1752 KHLF-------------------EARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLT 1797
            .|.|                   .||:.:||.|..|||||..:|      ||
  Fly  1905 VHSFLSASESSTSAPAPRNPQLQAARNAVLSHLPRIMSSVAAIW------DS------------- 1950

Human  1798 TINLGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNER------------RQNKTTTRTKVIP 1850
              .||..:.:|||:||.|.|:|::||.:|:||:|..|.:|            .|.:..:..:..|
  Fly  1951 --ELGQLRPVRQQLLEFLSPVSLHHGSNFLAAVAVTWQQRGIATNMNGLSIAEQFQRNSVLQACP 2013

Human  1851 AASEEQLLLVELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVP 1915
            |    ||.||.||.||.||..::.:.|:..|::.||.|.:....||:||..|:.||.|::..|.|
  Fly  2014 A----QLSLVSLVSSIRVMPMDSFVMTLHHVVRSPPPIHRPPAQLSIEVSALELFYFYMKSAPAP 2074

Human  1916 NLVDSWASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSL--ENKKDQRDLQDVTHKIVDAI 1978
            .|.|:|:|||.|::|.:.|:.||  ||.:|.:||||:.:.|.:  ::||:.|:|.|||.::||::
  Fly  2075 QLADAWSSLLALIRDGLNLTPPA--QFALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSRLVDSL 2137

Human  1979 GAIAGSSLEQTTWLRRNLEVKPSPKIM-----VDGTNLESDVEDMLSPAMETANITPSVYSVHAL 2038
            .::|||.|||||||||||.||.....:     |.|..|:.                   ||:.|.
  Fly  2138 SSVAGSCLEQTTWLRRNLAVKEDTDGLAKDNSVGGGGLQQ-------------------YSLQAQ 2183

Human  2039 TLLSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGYQYT 2103
            ::|:.:|::|||:.:.|.||::|:.::..:::.:.|||:||:|.|.|.:.||..||:||||||||
  Fly  2184 SVLAAILSNLLDVAYGSQEKDKVVNIVTPLLYNITPYLKNHTARNVPFFYACSALLASLSGYQYT 2248

Human  2104 RRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSSLNLFANRD 2168
            |:||:|:..||.:|.:||||..||:..||.|||:|||:|.||||:|||||:::|:.|||:|.:||
  Fly  2249 RKAWRKDMLDLLLDNAFFQMHLSCLPFWRMIMDSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRD 2313

Human  2169 VELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRL-PQVPTLHSQVFLFFRVLLLRMS 2232
            .|.||||||||||||.|:.||.||:.||:|||||:|..|||| |..|::.:.|||.|||||||||
  Fly  2314 QEYEQRAMLLKRLAFVIYCSEFDQHNKYMPDIQEQLANSLRLVPMGPSVQAAVFLCFRVLLLRMS 2378

Human  2233 PQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYTGGNGFSTSYNS----QR 2293
            |.|:|||||.:|.|:|||||.|||||.::.:.........:|::.:::..:|.|..|||    |.
  Fly  2379 PDHVTSLWPIIIAEMVQVFLQMEQELKSESEERNQQLRLPSGIDVSWSAASGASNGYNSQTPMQH 2443

Human  2294 WLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRRQGIHQRE----------- 2347
            |.::.|.|||.|:|...||:..||.||||||||:....|          :|:.|
  Fly  2444 WRSVQLEACKLLELGCVLPATKLPHFQMYRWAFVGTEFD----------VHEEEVCLPNGSLENL 2498

Human  2348 -------FKPYVVRLAKLLRKRAKDKEEDFKTVILEGLEMAKHQKNPEEDNSGRTLGWEPGHLLL 2405
                   :.|:|.|:|:|:     |.:...::.||:         .|    |.|       ||:|
  Fly  2499 ATLPSALYVPHVRRVARLM-----DMKYTSQSPILQ---------RP----SNR-------HLML 2538

Human  2406 TICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKI 2470
            ....::|:::|..||..|.                    .|...|......||.   .:...::|
  Fly  2539 HFQQLQSLQELYAFFTTLG--------------------ISCPQPRNFADTEND---VANCLKEI 2580

Human  2471 EEMVEKDFLE 2480
            ||::..||||
  Fly  2581 EEVLANDFLE 2590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DOP1A	XP_016866048.1	None
CG15099	NP_001261081.1	Dopey_N	18..304	CDD:282036	154/286 (54%)
		Dopey_N	<2200..2477	CDD:296427	150/276 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160029
Domainoid	1	1.000	721	1.000	Domainoid score	I111
eggNOG	1	0.900	-	-		E1_COG5221
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26645
Inparanoid	1	1.050	971	1.000	Inparanoid score	I320
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46621
OrthoDB	1	1.010	-	-		D29961at2759
OrthoFinder	1	1.000	-	-		FOG0003065
OrthoInspector	1	1.000	-	-		otm41469
orthoMCL	1	0.900	-	-		OOG6_102162
Panther	1	1.100	-	-	O	PTHR14042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R332
SonicParanoid	1	1.000	-	-		X2429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800