DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment USP33 and usp33

DIOPT Version :9

Sequence 1:	NP_055832.3	Gene:	USP33 / 23032	HGNCID:	20059	Length:	942	Species:	Homo sapiens
Sequence 2:	NP_998392.1	Gene:	usp33 / 406508	ZFINID:	ZDB-GENE-040426-2323	Length:	897	Species:	Danio rerio

Alignment Length:	910	Identity:	642/910 - (70%)
Similarity:	745/910 - (81%)	Gaps:	23/910 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    37 NHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKH 101
            |.||||:.|||||||:|||||.|.||||||.||||||||||.|||||||||..||||:|||||:|
Zfish     7 NDCPHLECVGEITKEELIQKSHGQCQDCKVGGPNLWACLENGCSYVGCGESHADHSTVHSQETRH 71

Human   102 YLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIP-SNTTLKTPLVAV 165
            .|||||||||||||||:|||||:||||....||:..:.....:...||...| |.|:|:.|....
Zfish    72 NLTVNLTTLRVWCYACTKEVFLERKLGPHKQLPNAAKAVSPVQTPCQDLNTPGSPTSLRVPSAGT 136

Human   166 FDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICK 230
            .||||:|.:||||||.|||||||||||||||||||||||||||||||||:||||.:||||||:||
Zfish   137 CDDLDMETEEEDELRTRGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLECGGLVKTDKKPALCK 201

Human   231 SYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVE 295
            ||.||:|:||||:|...||||.||||||.|||.||||||||:|||||||||.|||||||.:.|.|
Zfish   202 SYQKLVTDLWHKNRNSYVVPTNLFQGIKAVNPMFRGYSQQDSQEFLRCLMDQLHEELKELIPEPE 266

Human   296 EDPQTITTEETMEEDK-SQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENNSEM 359
            :..|.:..:::.:||. |||| ||||||||.:||||:|| |.| ..||.||..||:.:...|
Zfish   267 DPNQAVAMDDSPDEDNHSQSD-DFQSCESCGSSDRADNE-GPR-VPEDINEAEMLMPEQNQN--- 325

Human   360 SKDWQKEK-MCNKINKVNSEGEFDKDRDSISETVD-LNNQETVKVQIHSRASEYITDVHSNDLST 422
            ::|||||| :.|.:.:..|.|:.|||.|:.|::.. :::|..:|.|  .|.|:  :::..:....
Zfish   326 NRDWQKEKNLINNLYRAGSHGDLDKDVDTTSDSRPIISSQGAIKAQ--GRTSD--SEIQVSSTVR 386

Human   423 PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSV 487
            ||....|||:..|||:||||| :.||.|:..|||....:|.:.|:.:||.|:||::|||||:|||
Zfish   387 PQSPTGNEGITSRLSSSPPKS-SAWPNLSSTHKKVPMFTPTKTKRQRKYHSIISEVFDGTIVSSV 450

Human   488 QCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKR 552
            |||||||||||||.|||:||||||||||||||||||.|::||||||||||||||||||.|||:|
Zfish   451 QCLTCDRVSVTLENFQDISLPIPGKEDLAKLHSSSHQTALVKAGSCGEAYAPQGWIAFVMEYIK- 514

Human   553 FVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLK 617
                   |||||||||||||||||||||||||||||||||||||||||||||||:.|||||||||
Zfish   515 -------SWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQSLPEILCIHLK 572

Human   618 RFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNL 682
            ||||||||||||.||||||||||::||||||||.|...|||||||||||||||||||||||||.|
Zfish   573 RFRHELMFSTKIGTHVSFPLEGLEMQPFLAKDSSALTTTYDLLSVICHHGTASSGHYIAYCRNEL 637

Human   683 NNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWL 747
            |.||||||||||||||||.|||||||||||:||::|.|||||::::|.|:|||||||||:|||||
Zfish   638 NQLWYEFDDQSVTEVSESCVQNAEAYVLFYKKSNDETQKERRKVTSLFNMMEPSLLQFYVSRQWL 702

Human   748 NKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICHT 812
            ||||||||||||||:||||.|||:||.||.||:|||||:|||:||:|||||||||||||||:|||
Zfish   703 NKFKTFAEPGPISNHDFLCAHGGIPPNKATYIDDLVLMIPQNVWDHLYSRYGGGPAVNHLYVCHT 767

Human   813 CQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTK 877
            ||.|.||:|||||.||::|:|||:|||:|:||...|||||||||||||||||||.||||||||:|
Zfish   768 CQNEIEKLEKRRKNELDMFVRLNKAFQEEESPVVIYCISMQWFREWESFVKGKDIDPPGPIDNSK 832

Human   878 IAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDILQAEEKIEVETRSL 942
            |||.|.|::.|:.|||||||||||||||.:|:||||.|.:||.|.|.:.:..|:|||||||||::
Zfish   833 IAVNKNGHITLKPGADSGQISEETWNFLHNIHGGGPVVTVRPSVSHQESETSQSEEKIEVETRTV 897

Human 943 942
Zfish 898 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USP33	NP_055832.3	zf-UBP	61..121	CDD:280334	51/59 (86%)
		UCH	184..712	CDD:278850	371/530 (70%)
		Peptidase_C19	186..>288	CDD:271592	85/101 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..357		30/63 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..469		21/49 (43%)
		Peptidase_C19R	473..713	CDD:239139	208/239 (87%)
		DUSP	734..803	CDD:299905	58/68 (85%)
		DUSP	840..924	CDD:197831	61/83 (73%)
usp33	NP_998392.1	zf-UBP	31..91	CDD:280334	51/59 (86%)
		UCH	155..667	CDD:278850	371/530 (70%)
		Peptidase_C19	156..>418	CDD:271592	156/272 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..308		25/49 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..420		30/81 (37%)
		Peptidase_C19R	435..668	CDD:239139	208/240 (87%)
		DUSP	687..769	CDD:197831	69/81 (85%)
		DUSP	795..879	CDD:197831	61/83 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	875..897		12/21 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194324535
Domainoid	1	1.000	740	1.000	Domainoid score	I990
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8996
Inparanoid	1	1.050	1322	1.000	Inparanoid score	I1303
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46045
OrthoDB	1	1.010	-	-		D147564at2759
OrthoFinder	1	1.000	-	-		FOG0003021
OrthoInspector	1	1.000	-	-		oto46902
orthoMCL	1	0.900	-	-		OOG6_103732
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6374
SonicParanoid	1	1.000	-	-		X2011
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300