DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment USP33 and ubp1

DIOPT Version :9

Sequence 1:	NP_055832.3	Gene:	USP33 / 23032	HGNCID:	20059	Length:	942	Species:	Homo sapiens
Sequence 2:	NP_587999.1	Gene:	ubp1 / 2539228	PomBaseID:	SPCC16A11.12c	Length:	849	Species:	Schizosaccharomyces pombe

Alignment Length:	872	Identity:	191/872 - (21%)
Similarity:	308/872 - (35%)	Gaps:	292/872 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    43 DSVGEITKEDLIQK------SLGTCQDCKVQGPNLW-----------ACLENRCSYVGC------ 84
            |:.|.||:..|:.:      ||....|..:...:||           ..:|.:...||.
pombe    66 DNPGPITQWRLLDEKNELKHSLEESIDYSIVSASLWHMLVEWFGLEGLAIERKVLLVGLAAEQKP 130

Human    85 -------------------GES-------QVD---HS---------------TIHSQETKHYLTV 105
                               ||:       |:|   ||               :::.|..:.:...
pombe   131 FVDIYPINFTLHVLFDPINGENTSYSPLYQIDEPYHSDEPYAFSFSRSDTLRSLYKQVMEAFQIS 195

Human   106 NLTTLRVW----CYACSKEVFLDRKLGTQPSLPHVRQ--------PHQIQENS-VQDFKIPSNTT 157
            :.|:.|:|    ....|:.|.|. :...||::..:.:        ...|.:.| :.:|:.|:...
pombe   196 DGTSFRLWYLNKSNLSSRFVSLS-EFNDQPAIALLSEYAVCMTIFEIDIADGSLLLEFQHPNGEW 259

Human   158 LKTPLVAVFDDLDIEADEEDEL---RARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLD---- 215
            |...:.           :|..|   :..||.||.|:||:||||:|||.:.:...||::||.
pombe   260 LSDSIT-----------KEQNLTINKEIGLCGLYNLGNSCYMNSALQCMIHTHELTKYFLSDSYE 313

Human   216 --------CGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDA 272
                    .|.:.:      :..||..|:..:.|.:...||.|::....|...|..|.||.|||:
pombe   314 KDINYNNPLGMMGK------VALSYASLLKMIHHTADMHSVSPSSFKFIIGEFNTYFSGYRQQDS 372

Human   273 QEFLRCLMDLLHEELKE-QVMEVEEDP----------QTITTE----ETMEEDKSQSDVDFQ--- 319
            |||:...:|.|||:|.. |:....|.|          |.:..:    .|...|.....: ||
pombe   373 QEFIAFFLDGLHEDLNRIQIKPYFERPDLFDEHPLHVQRVANQCWDIHTKRNDSIIVQL-FQGMY 436

Human   320 ----SCESCSNSDRA---------------------------ENENGSRCFSEDNNETT---MLI 350
                .|..|.....|                           ..::....:.|...|:|   |..
pombe   437 KSTLECSICYQKSTAFDPFMYLTLPLPTSAKWRHKVVYVPPFGTQSPVELYLELLMESTVIQMKF 501

Human   351 QDDENNSEMSKDWQKEKMCN----KINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEY 411
            |..|...:|..:..:...|:    |:.||                  |.|::.:..:||......
pombe   502 QATEKLQKMGLECGELTACDIYRGKVYKV------------------LKNKDKISKKIHKWDHVV 548

Human   412 ITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVIS 476
            :....:|.|:.|.:                            |...:.|.|      ..|:|  :
pombe   549 LYGSTANGLTIPIV----------------------------HGCKRPAMP------GSYQS--N 577

Human   477 DIFDGTI---ISSVQCLTCDRVSVTLETFQ-----DLSLPIPGKEDLAKLHSSSHPTSIVKAGSC 533
            |:|...:   :.|...||.|.|...:|.::     |:::   |...|......|      |||.
pombe   578 DVFGFPLQLNVRSRNVLTNDLVKEIVELYRVYAGIDVAI---GTLQLGLKRMES------KAGK- 632

Human   534 GEAYAPQGWIAFFMEYVKRF--------------VVSCV------------PSWFWGPV------ 566
                    |.......||||              |:.|:            ..|.:..:
pombe   633 --------WECIKEIEVKRFEIVEEEEIVIDDKTVIMCLWNDQQYEKLFYNCEWIFEKIQFHMES 689

Human   567 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFR-H--ELMFSTK 628
            :||:|||..|...::|...:.:.|..||..|...|..::...|:||.|||.||. |  :|....|
pombe   690 ITLEDCLLEFSKPEQLDLQDSWYCPGCKAFRPATKRLEIWRLPKILVIHLNRFSGHGGDLRRRRK 754

Human   629 ISTHVSFPLEGLDLQPFLA---KD----SPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 686
            ....|.:|:..|:|:.||:   ||    |..:.:.|||.:|..|||..|:|||.||.|:..:..:
pombe   755 RRDLVVYPVFDLNLKQFLSPFIKDHEWLSSQKSMLYDLYAVDNHHGFMSNGHYTAYARDASSQTF 819

Human   687 YEFDDQSVTEVSESTVQNAEAYVLFYR 713
            ::|||.::.|:....:..:.|||||||
pombe   820 FKFDDTAICEIDPEDIVTSSAYVLFYR 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USP33	NP_055832.3	zf-UBP	61..121	CDD:280334	17/124 (14%)
		UCH	184..712	CDD:278850	152/645 (24%)
		Peptidase_C19	186..>288	CDD:271592	39/113 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..357		16/113 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..469		5/49 (10%)
		Peptidase_C19R	473..713	CDD:239139	79/289 (27%)
		DUSP	734..803	CDD:299905
		DUSP	840..924	CDD:197831
ubp1	NP_587999.1	UBP12	1..849	CDD:227847	191/872 (22%)
		DUSP	45..123	CDD:197831	11/56 (20%)
		Peptidase_C19	280..>472	CDD:271592	51/198 (26%)
		Peptidase_C19	280..>394	CDD:271592	41/119 (34%)
		Peptidase_C19R	<690..846	CDD:239139	55/155 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21646
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000