Protein Alignment KDM4B and seq

DIOPT Version :10

• Sequence 1: NP_001398077.1
• Gene: KDM4B / 23030
• HGNCID: 29136
• Length: 1130
• Species: Homo sapiens
• Sequence 2: NP_001027415.1
• Gene: seq / 3772396
• FlyBaseID: FBgn0028991
• Length: 882
• Species: Drosophila melanogaster
• Alignment Length: 594
• Identity: 92/594 - (15%)
• Similarity: 168/594 - (28%)
• Gaps: 275/594 - (46%)

Human   215 EHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKY-----GIPFSRITQEAGEFMITF-- 272
            |.|:.||::::       :|.|              :.:|     |:.:..:..: .:...||
  Fly   376 EQGEYLEKMSV-------RGLD--------------IARYEHIIDGVAYCLVCAK-NDIFKTFKN 418

Human   273 -------PYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERY 330
                   .|.:|.|.|.                   |:.....|.|:..:           |::.
  Fly   419 KYSFQRHAYLFHEGQNR-------------------KIFACPICNKEFSR-----------PDKM 453

Human   331 ELWKQGK--DLTVLDHTRPTALTSPELSSWSASRASLKAKLLRRQISLKENRHWRKTEEERKPSL 393
            ::.|:.|  |:.:    .|:|.|:|           |||                    :..|:
  Fly   454 KMHKKDKHGDVPM----PPSATTTP-----------LKA--------------------DGPPA- 482

Human   394 ERKKEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEGTAGA--ALLEEAGGSVKEEAGPEVDPEEEE 456
              |:.:|.|          .|:..|.:|...|.:.....  ::|::..........|......::
  Fly   483 --KRARTAR----------TPRVRKTKDGSTPTKKRLAQIDSVLDDVQNGESLTMAPVSVSHSQQ 535

Human   457 EEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAH----FPSEE--ALWL 515
            ::.|.:.|                           |...|.|..|..|.|    .||.:  .:.|
  Fly   536 QQQQQIQH---------------------------SITTLAPSTPSQPQHQLQTLPSLDFSGMIL 573

Human   516 PSPLEPPVLGP----------GPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPG 570
            |...:..:..|          |||.....|.|....:    :.|.:||.:...:...|     .|
  Fly   574 PGGAQLALANPGATSSVGLQRGPATPNGQPAPPTTTL----IYSNQLELQQALLQQQL-----QG 629

Human   571 KAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFS 635
            ::...|:            |.|     .:.|::|.|.:        ....|..:|...|..:|:.
  Fly   630 QSIMIQD------------QAG-----NLVPLQLDGTQ--------AIYTTAPQAQRQQTTATYQ 669

Human   636 KLKMEIKKSRRHPLGRPPTRSPLSVVKQE----------ASSDEEASPFSGEE------------ 678
            ..:.:.::         |.:.|....:|:          .||...|:|.|.|:
  Fly   670 TTQQQQQQ---------PAQQPAGQAQQQPHYELDNVTYLSSTAAATPTSAEQQQQQQQQQHVIG 725

Human   679 -----DVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAP 738
                 .:..||.|:            :||.:                          |:|
  Fly   726 TVQSYQILTPDGLQ------------NFQPK--------------------------LET----- 747

Human   739 IASLGEGCP 747
             |.||:.||
  Fly   748 -AELGDLCP 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM4B	NP_001398077.1	JmjN	15..56	CDD:128818
		JmjC	176..292	CDD:396791	14/90 (16%)
		PHD_JMJD2B	717..822	CDD:277051	7/31 (23%)
		ePHD_JMJD2B	831..940	CDD:277184
		Tudor_JMJD2B_rpt1	953..1006	CDD:410535
		Tudor_JMJD2B_rpt2	1010..1065	CDD:410538
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	3/26 (12%)