Protein Alignment KDM4B and Kdm4B

DIOPT Version :10

• Sequence 1: NP_001398077.1
• Gene: KDM4B / 23030
• HGNCID: 29136
• Length: 1130
• Species: Homo sapiens
• Sequence 2: NP_001260942.1
• Gene: Kdm4B / 318918
• FlyBaseID: FBgn0053182
• Length: 717
• Species: Drosophila melanogaster
• Alignment Length: 734
• Identity: 292/734 - (39%)
• Similarity: 378/734 - (51%)
• Gaps: 161/734 - (21%)

Human    14 KIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQT-YDDID--DVVIPAPIQQV 75
            :|..||||.||||||.|||||:||||||:|||||::||.||.||:: |.|:|  :|.|||||.||
  Fly     8 RIKVFRPTWEEFKDFPKYVAYMESQGAHKAGLAKVVPPPEWVPRRSGYADLDALNVTIPAPICQV 72

Human    76 VTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGS 140
            |||:.|.:.|.|||||.:||.::..||::|:|.||:|.||:|||||||||:|:|:||||||:|||
  Fly    73 VTGKQGYYQQINIQKKPLTVKQFSELASTERYATPKHFDFEDLERKYWKNITYVAPIYGADVSGS 137

Human   141 LYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGE 205
            :.|.|...|||..|.||||.|.::....|:||||.|||||||||||||||||||||||||||||.
  Fly   138 ITDTDQDSWNINRLGTILDYVNKDYNIQIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGA 202

Human   206 PKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI 270
            ||:||.:|||.|::||::|..:||.|.:.|:|:||||||||||.|||::.:|.|:|||||||.||
  Fly   203 PKTWYVVPPECGRKLEKVANQYFPASYKNCNAYLRHKMTLISPQILKQHDVPVSKITQEAGEIMI 267

Human   271 TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQ 335
            |||:|||||||||||||||||||..|||:|||.|.||||..||||||||.||:..|.:||:||.:
  Fly   268 TFPFGYHAGFNHGFNCAESTNFAMERWIEYGKRAVQCTCSNDMVKISMDTFVKRFQSDRYDLWME 332

Human   336 GKDLTVLDHTRPTALTS-----PELSSWSASRASLKAKLLRRQISLKENRHWRKTEEERKPSLER 395
            |:|:.......|.|:.|     |.|.      ..|..|.:::|.    |....|:.:||.|.|:.
  Fly   333 GRDVGRHPEDPPNAVLSAAPLPPHLD------VLLCDKKMKKQC----NPTKAKSFKERNPDLDL 387

Human   396 KKEQTKRPGLSSHRKRSQPKKPKPEDPK---------------------FPGEGTAGAALLEEAG 439
            .:.| :.|.:             |:|.|                     ||.|.  ..:|...|.
  Fly   388 DEIQ-QNPNV-------------PDDVKAMLKESVLTLDTGDLATDEADFPNED--AMSLQSPAN 436

Human   440 GSVKEEA------GPEVDPEEEEEEPQPLP-----------------------HGRE-------- 467
            ...|:|.      |.|.|.|||:.:.:...                       .||.
  Fly   437 LKTKQELLEYIDDGTEDDDEEEDFKRRKQKRRYDADYDDDWLASKRKTNSRNNRGRSPRTKDDRS 501

Human   468 ---AEGAEEDGRGKLR------PTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPV 523
               |.......||..|      |.|..:.|||.|....|.         .|..|..:.:|....|
  Fly   502 ISPASSTSSTSRGARRGKASGTPRKTPARRKKDSITTSPA---------VSSAATAVKTPTSAVV 557

Human   524 LGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHF 588
            .|....|...:|                               |..|.....:|..|.|     |
  Fly   558 AGTTSIATTTTP-------------------------------PADGGGDAKKERQSLQ-----F 586

Human   589 AQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPP 653
            .|:...::..:..:..|....|.|::.|....:|:..|:.|.....:.|               |
  Fly   587 MQQSRKFEGKIPKLSQTSAATGGATAAAEASTSKSSQGQQQQIVYVNML---------------P 636

Human   654 TRSPLSVVKQEASSDEEAS 672
            ..:.|:.:.|:....:.||
  Fly   637 AANTLNGIPQQQQQQQYAS 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM4B	NP_001398077.1	JmjN	15..56	CDD:128818	31/40 (78%)
		JmjC	176..292	CDD:396791	88/115 (77%)
		PHD_JMJD2B	717..822	CDD:277051
		ePHD_JMJD2B	831..940	CDD:277184
		Tudor_JMJD2B_rpt1	953..1006	CDD:410535
		Tudor_JMJD2B_rpt2	1010..1065	CDD:410538
Kdm4B	NP_001260942.1	JmjN	5..50	CDD:128818	31/41 (76%)
		JmjC	173..289	CDD:396791	88/115 (77%)