DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM4B and jmj3

DIOPT Version :9

Sequence 1:	XP_005259578.2	Gene:	KDM4B / 23030	HGNCID:	29136	Length:	1130	Species:	Homo sapiens
Sequence 2:	NP_595639.1	Gene:	jmj3 / 2540780	PomBaseID:	SPBC83.07	Length:	752	Species:	Schizosaccharomyces pombe

Alignment Length:	820	Identity:	168/820 - (20%)
Similarity:	259/820 - (31%)	Gaps:	225/820 - (27%)

- Green bases have known domain annotations that are detailed below.

Human     2 GSEDHGAQNPSCK----------IMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKE--- 53
            |..|....:..|:          |....|.:.||.|...::..:|..| .:.|..|::.|..
pombe    11 GKSDTSVSSLECEIDYHIEGSDGIPVVEPKISEFVDMESFIRRVERLG-KKYGAIKVVRPSSVLN 74

Human    54 -WKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRL--------ANSEKYCT 109
             |.        :|.:.|:.::.      .|:.:..:::|    |||..:        |..:|
pombe    75 PWN--------EDTMKPSDVKM------DLWLERMVRRK----GEYFEIQSDIDHGSAGPKK--- 118

Human   110 PRHQDFD-----------DLERK-------YWKNLTFVSPIYGADISGSLYDD--DVAQWNIGSL 154
            |...:.|           |.|..       ||::||..|..||       |.:  .:..:.|.|:
pombe   119 PTDMNVDDRFPSNAGSSNDFENNVAKAIAYYWRSLTHDSLWYG-------YTNRPSIPFYFIPSI 176

Human   155 RTI-LDMVERECGTIIE-GVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHG 217
            ... .|.|.....|:|. ..|..:|:.|.||||..|..|..:|:::.....|....||.||..|.
pombe   177 SAAQKDRVHLRSNTLINTWPNVGHLFAGKWKTTLPWRVESPELHAVQVHLGGSSLQWYVIPSAHS 241

Human   218 KRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNH 282
            :..::||..........|..||.|:..|..|..|.:.||.......:..|.:||||..:|:.|
pombe   242 ESFKKLAGKLAQDEHWRCSDFLLHQNILFPPSTLVQNGIVTYSTVLKQDELLITFPGTHHSAF-- 304

Human   283 GFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRP 347
                                      |..|.| :...||........||          ..:.|.
pombe   305 --------------------------CLGDAV-LRRFVFRSPRSASNYE----------FSNLRR 332

Human   348 TALTSPELSSWSASRASLKAKLLRRQISLKE---------NRHWRKTEEERKPSLERKKEQTKRP 403
            ..::....||.|....|.|.:....|..|.|         |.|..........|::...
pombe   333 LMVSESLYSSKSLWPHSHKPQRACSQKFLDEFYLHDLPESNIHDSGNFHPIHSSVDNNS------ 391

Human   404 GLSSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREA 468
              .|.|....|....|..|......:|..........:.||.:...|. ||.:....||
pombe   392 --FSQRDFDSPNSINPPSPLMSNHESASTEHFNSTTTTEKELSSLHVG-EERKNRSLPL------ 447

Human   469 EGAEEDGRGKLRPTKAKSERKKK---------SFGLLPPQLPPPPAHFPSEEALWLPSPLE-PPV 523
                    ..:..:||:.|..||         .|....|....|.:|           ||. ||:
pombe   448 --------SLIWNSKAREEYIKKQKEENGDNIEFSHFDPLYTRPSSH-----------PLHPPPI 493

Human   524 LG-PGPAAMEESPLPAPLNVVPPEVPSEE---LEAKPRPIIPMLY-VVPRPGKAAFNQEHVSCQQ 583
            || |.||......|  .|..:..:..||.   ||.:...::.:.| .:.....||..:|     .
pombe   494 LGLPVPAQFARGEL--FLGRILEDRVSEHMLLLECEKSDVVEVPYECILTSSSAAGRRE-----S 551

Human   584 AFEHFAQKGP----------TWKE----------------PVSPMELTGP---EDGAASSGAGRM 619
            ::.:.|.|.|          .|.|                |..|:|.|.|   |..:..:.|...
pombe   552 SYYNPALKAPNIVYDDGVPINWNEYSELPSLDRFVLPKLLPGKPIEFTPPISVEPTSIKTIAAEE 616

Human   620 ETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSG-EEDV--- 680
            .::..:....||:....:.:.::..............||  |.:....|.|.|..:. ||||
pombe   617 SSEPTSSVDVAPTPVEDVNVNLESISNTNESVVDLSDPL--VSKNGFEDVERSSVADLEEDVLET 679

Human   681 -------SDPDALRPLLSLQWKNRAAS-FQAERKFNAAAA 712
                   ||.|....::     :|:.| ..:|.:|:.|.|
pombe   680 RSSIFETSDIDDRLTVI-----DRSQSVVPSESEFSIAGA 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM4B	XP_005259578.2	JmjN	15..56	CDD:128818	11/44 (25%)
		JmjC	176..292	CDD:202224	33/115 (29%)
		PHD_JMJD2B	717..822	CDD:277051
		ePHD_JMJD2B	831..940	CDD:277184
		TUDOR	955..1007	CDD:197660
		TUDOR	1009..1064	CDD:197660
jmj3	NP_595639.1	JmjN	33..74	CDD:128818	10/41 (24%)
jmj3	NP_595639.1	JmjC	200..316	CDD:202224	36/144 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910