DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM4B and Kdm4b

DIOPT Version :9

Sequence 1:	XP_005259578.2	Gene:	KDM4B / 23030	HGNCID:	29136	Length:	1130	Species:	Homo sapiens
Sequence 2:	XP_030105461.1	Gene:	Kdm4b / 193796	MGIID:	2442355	Length:	1124	Species:	Mus musculus

Alignment Length:	1163	Identity:	908/1163 - (78%)
Similarity:	982/1163 - (84%)	Gaps:	72/1163 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDD 65
            ||||||.|||||||||||||||:||:|||:|||||||||||||||||||||||||||||||||||
Mouse     1 MGSEDHSAQNPSCKIMTFRPTMDEFRDFNRYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDD 65

Human    66 VVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVS 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 VVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVS 130

Human   131 PIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDL 195
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   131 PIYGADISGSLYDDDVAQWNIGNLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDL 195

Human   196 YSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSR 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 YSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSR 260

Human   261 ITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRIL 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 ITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRIL 325

Human   326 QPERYELWKQGKDLTVLDHTRPTALTSPELSSWSASRASLKAKLLRRQISLKENRHWRKTEEERK 390
            ||||||.||||:|||||||||||||:|||||||||||.|:||||||||||:||:|.|||.||
Mouse   326 QPERYEQWKQGRDLTVLDHTRPTALSSPELSSWSASRTSIKAKLLRRQISVKESRPWRKAEE--- 387

Human   391 PSLERKKEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEE 455
               ||::|.|:|||.:|||:||||||.|||:.:.|||.|||.:.|:||.|..:.||.||   :||
Mouse   388 ---ERRREPTRRPGPASHRRRSQPKKSKPEESRSPGEATAGVSTLDEARGCSRGEAMPE---DEE 446

Human   456 EEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLE 520
            |||..| ..|.||||.|||||||.|||||::::|..| ...||.|..|||.||:||.| .|.| :
Mouse   447 EEELLP-SQGHEAEGVEEDGRGKPRPTKARNKKKTPS-PSSPPLLSAPPALFPTEEVL-RPPP-Q 507

Human   521 PPVLGP--GPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQ 583
            |...||  ||.|.|..|.|.|||||||..|.||.|.:||||||||||:||......::||.:..|
Mouse   508 PKSPGPAMGPMAAEGGPPPTPLNVVPPGAPVEEAEVRPRPIIPMLYVLPRTSSTDGDREHSAHAQ 572

Human   584 AFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHP 648
                           ::|||| |||:          |.:|:||:.|..:.|||||:|||||||||
Mouse   573 ---------------LAPMEL-GPEE----------ENQAQAGDSQGTTPFSKLKVEIKKSRRHP 611

Human   649 LGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAAR 713
            |||||||||||||||||||||||..||||:||:||:|||.||||||||:|||||||||||||||.
Mouse   612 LGRPPTRSPLSVVKQEASSDEEAFLFSGEDDVTDPEALRSLLSLQWKNKAASFQAERKFNAAAAL 676

Human   714 TEPYCAICTLFYPYCQ---------------ALQTEKEAPIASLGEGCPA-TL------------ 750
            :|||||||||||||.|               ...|:.:..:|..|....| ||
Mouse   677 SEPYCAICTLFYPYSQVSCLSGLPTLMAPTVTCPTQPQCSLAYCGPALSAVTLQSVQTERDSAVQ 741

Human   751 -PSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVN 814
             ||||.|:||||||||||||.||||||||||||:|:|||||||:|..|||||||||||:||||..
Mouse   742 PPSKSGQRTRPLIPEMCFTSSGENTEPLPANSYVGEDGTSPLISCAHCCLQVHASCYGVRPELAK 806

Human   815 EGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPE 879
            ||||||||||||||||||||||||||||.||:.|||||||||||||.||||||||:|||:|||||
Mouse   807 EGWTCSRCAAHAWTAECCLCNLRGGALQRTTEHRWIHVICAIAVPEVRFLNVIERNPVDVSAIPE 871

Human   880 QRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGG 944
            |||||||:|||||||:|||||||||||||||||||||||||||||||||||||||||||||::.|
Mouse   872 QRWKLKCIYCRKRMKRVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHRASG 936

Human   945 HAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLG 1009
            ...||||.|||||:|||||||||||||||||..:||.||||||||||||||||||||||||::||
Mouse   937 AGGQLLRTVSLGQIVITKNRNGLYYRCRVIGTTAQTFYEVNFDDGSYSDNLYPESITSRDCLRLG 1001

Human  1010 PPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSL 1074
            ||.|||||||||||||||:|:|||..||.||||||||||||||||||||||||||||||||||||
Mouse  1002 PPPEGELVELRWTDGNLYRARFISMATSLIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSL 1066

Human  1075 STGAPQEPAFSGEEAKAAKRPRVGTPLA--TEDSGRSQDYVAFVESLLQVQGRPGAPF 1130
            |||.||||:|||::.||||||||.:.||  |||:|||.:|::|:|||||.||||||||
Mouse  1067 STGTPQEPSFSGDDVKAAKRPRVASVLATTTEDTGRSPEYLSFMESLLQAQGRPGAPF 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM4B	XP_005259578.2	JmjN	15..56	CDD:128818	37/40 (93%)
		JmjC	176..292	CDD:202224	115/115 (100%)
		PHD_JMJD2B	717..822	CDD:277051	77/133 (58%)
		ePHD_JMJD2B	831..940	CDD:277184	100/108 (93%)
		TUDOR	955..1007	CDD:197660	46/51 (90%)
		TUDOR	1009..1064	CDD:197660	48/54 (89%)
Kdm4b	XP_030105461.1	JmjN	15..56	CDD:128818	37/40 (93%)
		JmjC	176..292	CDD:334913	115/115 (100%)
		PHD_SF	680..814	CDD:389947	77/133 (58%)
		PHD_SF	823..932	CDD:389947	100/108 (93%)
		Tudor_2	948..982	CDD:375553	28/33 (85%)
		Tudor_2	1006..1040	CDD:375553	28/33 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83963098
Domainoid	1	1.000	554	1.000	Domainoid score	I6107
eggNOG	1	0.900	-	-		E1_COG5141
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27773
Inparanoid	1	1.050	1785	1.000	Inparanoid score	I2087
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52663
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		oto112082
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300