DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RBM34 and rbm34

DIOPT Version :9

Sequence 1:	NP_055829.2	Gene:	RBM34 / 23029	HGNCID:	28965	Length:	430	Species:	Homo sapiens
Sequence 2:	NP_001004890.1	Gene:	rbm34 / 448232	XenbaseID:	XB-GENE-5895036	Length:	412	Species:	Xenopus tropicalis

Alignment Length:	435	Identity:	213/435 - (48%)
Similarity:	281/435 - (64%)	Gaps:	40/435 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     5 GMSKRKRKR--SVQEGENPDDGVRGSPPEDYRLGQVASSLFRGEHHSRGGTGRLASLFSSLEPQI 67
            |.||:|.||  ::|..|...:.      |.|..|.|:|||| .:..|...| .|:|||.:..|.:
Frog     6 GKSKKKAKRMCNLQSNEAVGES------EAYVAGDVSSSLF-PKKASESAT-HLSSLFDTKGPAV 62

Human    68 QPVYVPVPKQTIKKTKRNEEEESTSQIERPLSQEPAK-KVKAKKKHTNAEKKLADRESALASADL 131
            |||||||     |..||...|...:.:::...:...| ||..:|:.:.:||||||||.:||:||.
Frog    63 QPVYVPV-----KIPKRKLPEAEGADVKKACKETVVKAKVTKEKELSVSEKKLADREQSLANADE 122

Human   132 EEEIHQKQGQKRKN--SQPGVKVADRKILDDTEDTVVSQRKKIQINQEEERLKNERTVFVGNLPV 194
            ||        .|||  |:..:|....:.|||  |.||.|.:|.::|:.|||:||:|||||||||.
Frog   123 EE--------TRKNVISKEKLKSKKNQSLDD--DGVVVQPRKRKVNRAEERIKNKRTVFVGNLPA 177

Human   195 TCNKKKLKSFFKEYGQIESVRFRSLIPAEGTLSKKLAAIKRKIHPDQKNINAYVVFKEESAATQA 259
            ...|:.|||.|||:|.|||:||||:..||..||:|:|||:||:||.:||||||:|||:||:|:||
Frog   178 DYTKQMLKSLFKEFGHIESMRFRSVARAEANLSRKVAAIQRKVHPKRKNINAYIVFKDESSASQA 242

Human   260 LKRNGAQIADGFRIRVDLASETSSRD-KRSVFVGNLPYKVEESAIEKHFLDCGSIMAVRIVRDKM 323
            ||||||::..||.||||:||:.||.| |||.|:|||||::||.|:..||.:||.:..|||:||:.
Frog   243 LKRNGAEVGSGFHIRVDIASKRSSHDNKRSAFIGNLPYEIEEEAVRDHFSECGKVQGVRIIRDQK 307

Human   324 TGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRVMRSVNKEKFKQQNSNPRLKNVSKPKQGLN 388
            |||||||||||||:.|:|.||||||||||.|||:||.||:..|. .|:::|    ..|..|:.|:
Frog   308 TGIGKGFGYVLFESADAVQLALKLNNSELSGRKIRVKRSLTAEA-AQKSTN----KSSDFKKKLD 367

Human   389 FTSKTAEGHPKSLFIGEKAVLLKTKKKGQKKS-----GRPKKQRK 428
             |.|.|:....:.|:||.|.:.|.|.||.|..     |..||:.|
Frog   368 -TLKQAKPLKGNSFVGETAEVGKVKNKGHKNKKKKTVGNKKKKNK 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM34	NP_055829.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		18/51 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..123		17/51 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..153		5/20 (25%)
		RRM	176..>382	CDD:223796	128/206 (62%)
		RRM1_RBM34	185..276	CDD:240840	60/90 (67%)
		RRM2_RBM34	288..360	CDD:240841	48/71 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..395		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..430		9/23 (39%)
rbm34	NP_001004890.1	RRM1_RBM34	168..259	CDD:240840	60/90 (67%)
rbm34	NP_001004890.1	RRM2_RBM34	272..344	CDD:240841	48/71 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I28347
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56691
Inparanoid	1	1.050	341	1.000	Inparanoid score	I9995
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG55363
OrthoDB	1	1.010	-	-		D1176212at2759
OrthoFinder	1	1.000	-	-		FOG0004008
OrthoInspector	1	1.000	-	-		oto159120
Panther	1	1.100	-	-	LDO	PTHR23236
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R827
SonicParanoid	1	1.000	-	-		X5022
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110