DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RBM34 and rbm-34

DIOPT Version :9

Sequence 1:	NP_055829.2	Gene:	RBM34 / 23029	HGNCID:	28965	Length:	430	Species:	Homo sapiens
Sequence 2:	NP_502291.1	Gene:	rbm-34 / 178148	WormBaseID:	WBGene00008688	Length:	394	Species:	Caenorhabditis elegans

Alignment Length:	441	Identity:	128/441 - (29%)
Similarity:	205/441 - (46%)	Gaps:	69/441 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     6 MSKRKRKRSVQEGENPDDGVRGSPPEDYRLGQVASSLFRGEHHSRGGTGRLASLF--SSLEPQIQ 68
            |:|:..||.. |..:.|.......|:..:..:.:..:...:::..||   |:|||  ||....:|
Worm     1 MAKKVVKRKA-EAVSADAEAVAEAPKKIKKQKPSLPVSEPDNYQAGG---LSSLFGKSSEGAAVQ 61

Human    69 PVYVPVPKQTIKKTKRNEEEESTSQIERPLSQEPAKKVKAKKKHTNAEKKLADRESALASADLEE 133
            ...|...| .|:|.||.:             .:|.||.:        |:|.||..:|......|.
Worm    62 EEVVKGDK-VIEKPKRRK-------------YDPKKKAE--------EEKAADAAAAAEEVAPET 104

Human   134 EIHQKQGQKRKNSQPGVKVADRKILDDTEDTVVSQRKKIQINQEEERLKNERTVFVGNLPVTCNK 198
            |..:|:.:.::..:...|..:.:.|..:             |......:|..||||||:|:|.|:
Worm   105 EGEEKKDENKEGKRDRTKQRENRTLQKS-------------NARASAAENALTVFVGNMPLTMNE 156

Human   199 KKLKSFFKEYGQIESVRFRSLIPAEGTLSKKLAAIKRKIHPDQKNINAYVVFKEESAATQALKRN 263
            |.::..|.::|.|.|||.|:|:||...|:|::..:..|::..|.::..||.|..|.:..:|||.|
Worm   157 KSVRRIFSDFGTISSVRMRNLLPANEKLTKRVTHLTGKLNDKQSSLTFYVKFGAEESVEKALKYN 221

Human   264 GAQIADGFRIRVDLASETSSRDKR-----SVFVGNLPYKVEESAIEKHF-LDCGSIMAVRIVRDK 322
            |.:: |...||||   :..|:.|.     ::||||||:::.|.|:...| ...|.:.||||||||
Worm   222 GTKL-DDHVIRVD---KVGSKKKEFGKDMAIFVGNLPFEITEDALITFFSAQIGPVEAVRIVRDK 282

Human   323 MTGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRVMRSVNKEKF-KQQNSNPRLKNVSKPKQG 386
            .||.||||.:|.|:...||.|||.:...::..|.||:.:.:.|... |.|.:..|..:..|.:..
Worm   283 DTGKGKGFAFVNFKQDSSVSLALSMETIKMEKRDLRITKVMKKGHLTKIQTAKKRTSHGKKNQNE 347

Human   387 L-------NFTSK---TAEGHPKSLFIGEKAVLLKTKKKGQKKSGRPKKQR 427
            :       .|::|   |.|.:       ::..|.|:.||...|....||.|
Worm   348 ITGKLHKFKFSTKKERTTEQN-------DRRALKKSAKKAIAKKKAAKKGR 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM34	NP_055829.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..123		13/50 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..153		3/18 (17%)
		RRM	176..>382	CDD:223796	79/212 (37%)
		RRM1_RBM34	185..276	CDD:240840	36/90 (40%)
		RRM2_RBM34	288..360	CDD:240841	34/72 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..395		8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..430		7/17 (41%)
rbm-34	NP_502291.1	RRM1_RBM34	144..233	CDD:240840	36/89 (40%)
rbm-34	NP_502291.1	RRM2_RBM34	247..320	CDD:240841	34/72 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I7585
eggNOG	1	0.900	-	-		E33208_3BIWG
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I3417
Isobase	1	0.950	-	0	Normalized mean entropy	S2864
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004008
OrthoInspector	1	1.000	-	-		oto20931
orthoMCL	1	0.900	-	-		OOG6_103046
Panther	1	1.100	-	-	LDO	PTHR23236
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R827
SonicParanoid	1	1.000	-	-		X5022
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.800