DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM1A and Su(var)3-3

DIOPT Version :9

Sequence 1:	XP_006710537.1	Gene:	KDM1A / 23028	HGNCID:	29079	Length:	878	Species:	Homo sapiens
Sequence 2:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster

Alignment Length:	885	Identity:	451/885 - (50%)
Similarity:	581/885 - (65%)	Gaps:	87/885 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    25 PGTAGGSENGSEVAAQPAGLSGPAE----VGPGAVGERTPRKKEPPRASPPGGLAEP-PGSAGPQ 84
            |...|||.         :.::.|.|    :...:.||.||::..   ..||..|:.| ||.  .|
  Fly     3 PTQFGGSS---------SKMTEPIEYVTLISDDSDGEPTPKRNV---NHPPSALSAPNPGQ--KQ 53

Human    85 AGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDE---YYSEEERNAKAE 146
            ..|......|       ..|.:.||||||.|.||:|........:.:.::   ..|....|.:||
  Fly    54 KHPDEDSNDA-------PATSDERRTSRRNRPKVDYSNRPSGSGDTASNDKSGSASMGPNNQQAE 111

Human   147 KEKKLPPPPPQAPPEEENESEPEEPSGQAGGLQDDSSGGYGDGQA------SGVEGAAFQSRLPH 205
            :..:     .|....|.|.:........||..:...:|...|..|      ||.|||.||||||.
  Fly   112 RRSQ-----SQTRKSEANATSSSVSGPSAGNSRPSQNGDSKDRDAGTPTVLSGQEGAVFQSRLPF 171

Human   206 DRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVH 270
            ::||..|.||||||........:|||.|||..|.:|:|||||||:||..|:.|..|::|:..||.
  Fly   172 NKMTPNEEACFPDISRSGILGHRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPPFDSEPSLVR 236

Human   271 RVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 335
            ||||:|||||.|||||:||:||:|.||.||||:||:|:||||.|.|||.|||||.:|||||||||
  Fly   237 RVHSFLERHGFINFGIFKRLKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGG 301

Human   336 RVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQ 400
            |::||||.:|:||:|||||||:.||||.::|||:.|:|..|:|.||||..:|:.||||||:::|:
  Fly   302 RISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIER 366

Human   401 EFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELL 465
            |||||||:.|||||:||||...:.|||||.|||.:|.:||..|..::.:|.::|:.||.::.|..
  Fly   367 EFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQR 431

Human   466 NKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEE---- 526
            .::..|::.|.:|..::......:.|         |....||....:|:: :..||.|:||
  Fly   432 RRLKTLRDTIGKLKNEHLAMINQRKP---------KGTDGDLKYCYQEFN-IRNTQIKMEETIST 486

Human   527 -------------KLQELEANPPSPLFFCSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHW 578
                         ||.|||.|.|      ||||||||||.|||||||||||||||.|:.||||||
  Fly   487 FHDLHAEEKQMLAKLHELEQNRP------SDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHW 545

Human   579 DQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYK 643
            ||||||||.|.|.|||||||||||||.|.|||::|:||::::|...|.||:|.|.::::....||
  Fly   546 DQDDDFEFIGHHTTVRNGYSCVPVALTENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYK 610

Human   644 CDAVLCTLPLGVLK--------QQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS 700
            .|.|:|||.|||||        ||...|:|.||||:||..|::|:||||||||||||||:||||:
  Fly   611 ADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPN 675

Human   701 VNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSA 765
            .|||||||||||||||:||||::..:|:|||||||.||.::|:::||:|:|||:::||.|||:::
  Fly   676 ANLFGHVGSTTASRGEMFLFWSISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTS 740

Human   766 VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTI 830
            |||||||||:|||:|||||||||||:.||||:||||:|.|:.| ||...| :.:|||||||||||
  Fly   741 VPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIP-PSSKDA-EGLPRLFFAGEHTI 803

Human   831 RNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGV 870
            ||||||||||.||||||||||||.:||    .|....|.:
  Fly   804 RNYPATVHGAYLSGLREAGRIADYYLG----YPEGTPPDI 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM1A	XP_006710537.1	SWIRM	197..284	CDD:282311	49/86 (57%)
		NAD_binding_8	303..361	CDD:290186	41/57 (72%)
		Amino_oxidase	308..851	CDD:279874	330/567 (58%)
		SurA_N_3	<395..491	CDD:304439	38/95 (40%)
		NAT_SF	<441..>549	CDD:302625	31/124 (25%)
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311	48/84 (57%)
		NAD_binding_8	269..327	CDD:290186	41/57 (72%)
		Amino_oxidase	274..824	CDD:279874	330/567 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158484
Domainoid	1	1.000	670	1.000	Domainoid score	I145
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32240
Inparanoid	1	1.050	834	1.000	Inparanoid score	I454
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52579
OrthoDB	1	1.010	-	-		D1034142at2759
OrthoFinder	1	1.000	-	-		FOG0001117
OrthoInspector	1	1.000	-	-		oto89702
orthoMCL	1	0.900	-	-		OOG6_103427
Panther	1	1.100	-	-	LDO	PTHR10742
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	1	1.000	-	-		X2101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800