Protein Alignment KDM1A and CG6034

DIOPT Version :9

• Sequence 1: XP_006710537.1
• Gene: KDM1A / 23028
• HGNCID: 29079
• Length: 878
• Species: Homo sapiens
• Sequence 2: NP_649005.1
• Gene: CG6034 / 39974
• FlyBaseID: FBgn0036750
• Length: 479
• Species: Drosophila melanogaster
• Alignment Length: 610
• Identity: 157/610 - (25%)
• Similarity: 239/610 - (39%)
• Gaps: 194/610 - (31%)

Human   295 TKKTGKVIIIGSGVSGLAAARQLQSFGM-DVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLG 358
            ||:|.|::|||:|.||:|||.:|...|. :|.|.||.||:|||:.|....|.:.||||....|..
  Fly    13 TKETAKIVIIGAGASGVAAATKLLEQGFKNVLLFEAEDRIGGRINTILFANSLIDLGAQWCHGEE 77

Human   359 GNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEAT-SYLSHQLDFN--- 419
            ||   ||.::|                      |:.|         :|:.| .|:.|.:..|
  Fly    78 GN---VVYEKV----------------------KDLD---------VLDRTGDYVVHFIRSNKEI 108

Human   420 ---VLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQ 481
               |.|.....|..|.||..: .|..|.|....:||                       :.:||.
  Fly   109 LTDVHNKALTELTNAFEVPGE-HEGSVGDAFNAYWK-----------------------ENIHQL 149

Human   482 YKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSPLFFCSDV- 545
            .        |.|.|              :.|      |.|..|::.:..::|        |.::
  Fly   150 V--------PNDKT--------------IAK------EAQDCLKKVICSMDA--------CDNLS 178

Human   546 YLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVP--VALAEGL 608
            .||.|       :|.|  ||.|.....||   |.|...::|..   .:.|.....|  ..:.:|
  Fly   179 ELSYR-------NFRN--FAIAGGDQNLS---WRQKGYWKFLS---VLLNSSDNQPGDQGILKG- 227

Human   609 DIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWK 673
            .:.||..:.::.:...|    .:..|..:..|: ..|.|:||:.||||:::...: |||.||..|
  Fly   228 HVHLNKRIAKINWEGDG----ELTLRCWNGQFV-SADHVICTVSLGVLREKHHKL-FVPALPASK 286

Human   674 TSAVQRMGFGNLNKVVLCFD--------------------------RVFWDPSVNLFGHVGSTTA 712
            ..:::.:..|.:||..|.|:                          :.||..||..|..|..
  Fly   287 IRSIEGLKLGTVNKFYLEFEEQPVPENIREMAFLWLEEDLKELRSGKYFWLESVCYFHRVDC--- 348

Human   713 SRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGI------FGSSAVPQPKE 771
                        :..:|...:.|..:..:|.||::       .:|:||      |...:||.||.
  Fly   349 ------------QPRLLQGWIIGAHSRYVETISEE-------QVLEGIMWMFRKFLKFSVPYPKN 394

Human   772 TVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAP----QPIPRLFFAGEHTIRN 832
            .:.|:|:::|..||||||         |...|..:..|.:...:|    ...||:.||||.:.||
  Fly   395 FLRSQWQSNPNFRGSYSY---------YSTYADELRTGRTDLASPLVDVTGRPRIQFAGEASSRN 450

Human   833 YPATVHGALLSGLREAGRIADQFLG 857
            :.:|||||:.||.|||.|:.:.:.|
  Fly   451 HFSTVHGAIESGWREAERLNEFYEG 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM1A	XP_006710537.1	SWIRM	197..284	CDD:282311
		NAD_binding_8	303..361	CDD:290186	28/58 (48%)
		Amino_oxidase	308..851	CDD:279874	147/589 (25%)
		SurA_N_3	<395..491	CDD:304439	19/102 (19%)
		NAT_SF	<441..>549	CDD:302625	16/108 (15%)
CG6034	NP_649005.1	Amino_oxidase	33..470	CDD:279874	143/583 (25%)
		NAD_binding_8	<35..88	CDD:290186	24/77 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840