DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO16 and myo16

DIOPT Version :9

Sequence 1:	NP_001185879.1	Gene:	MYO16 / 23026	HGNCID:	29822	Length:	1880	Species:	Homo sapiens
Sequence 2:	XP_001920958.3	Gene:	myo16 / 563752	ZFINID:	ZDB-GENE-070912-470	Length:	1910	Species:	Danio rerio

Alignment Length:	1941	Identity:	1070/1941 - (55%)
Similarity:	1355/1941 - (69%)	Gaps:	115/1941 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSHYHFIKCCCFQLCNVFRSHEMEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKAFQKQEG 65
            |||||||||||||||||||.: ||||||||||||||||||||:||||||::.|||||:..|||..
Zfish     1 MSHYHFIKCCCFQLCNVFRQN-MEIDQCLLESLPLGQRQRLVRRMRCEQLRVYYERERTLQKQSF 64

Human    66 FLKRLKHAKNPKVHFNLTDMLQDAIIHHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFI 130
            ...|..:.|..|:.|.|:|::|||||.|:|||||||||||||..|::||||||||||||:||.|.
Zfish    65 PKSRSTNRKKQKISFPLSDIIQDAIIRHDDKEVLRLLKEGADLSTVISSGGSLLHLCARHDNVFA 129

Human   131 AEILIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESS 195
            |||||::|:|||.||||.||.:|:|||||:.|:||||:|||.|||||||||||||||..||||:.
Zfish   130 AEILIEKGLNVNLQDEDLWTALHVACACDHADMVLLLLLAGVNVLLQDVNGNIPLDYTTEGTETR 194

Human   196 SILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVV 260
            .||:.:|:|||||::|:.|||.||..:|::|||..:||||:||::||:||||||:|.||||||||
Zfish   195 YILIRHLEENGVDMSSVHQMKSQRCFTMMSDVKQLVSSGGSVNQQNDDGVTLLHIASASGYKEVV 259

Human   261 SLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEM 325
            |::||:|.|:.:.|..||||||||||||||::|..||.|:|:|.|:|||::|.|||||:|.|.||
Zfish   260 SVLLENGADVLVSDSSYWTPLHLAAKYGQTHIVSQLLKHKADPTLLNCNQDKPSDIAATEHIAEM 324

Human   326 LLKAEIAWEEKMKEPLSASTLAQEEPYEEIIHD--LPVLSSKLSPLVLPIAKQDSLLEKDIMFKD 388
            ||:||..|.::.::| |||....|:...|...|  |||  .||:.:.|||:::||||||:.||:|
Zfish   325 LLRAEEFWVQRQRDP-SASPPQSEDHSAEANQDDNLPV--KKLATMALPISRRDSLLEKEAMFRD 386

Human   389 ATKGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDDLATLSELNDGSLLYEIQKRFGNNQIY 453
            :...|.:|.|.|:..:....|.:.|.|||||||||||||||:||||.|.|||||:||||.|:|||
Zfish   387 SGGALTQQASLDNGLDGSYPSAAGKLEQVKLMPPAPNDDLASLSELTDSSLLYEMQKRFANDQIY 451

Human   454 TFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILS 518
            |:||.||||:||||:|||||::|||||.||||:||||||||:||..|||||.:|:|:||||||:|
Zfish   452 TYIGHILLLINPYKDLPIYSNLVSQLYLSSSGRLCSSLPPHIFSSAERAFHMMFQERRPQCFIIS 516

Human   519 GERGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQF 583
            ||.|||||.|.|.|::||..|:......|:.|.|||..||||||||||.:|...|.|||...||:
Zfish   517 GESGSGKSVACKHILKHLAARSSPKGFALEPRMKHVNVILEAFGHAKTQMNTSGSRFIKLISLQY 581

Human   584 CERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNLCAHRYLNQTI 648
            |::::.|...|:|||:|||||::..|..|.||.||||:.:|||||||..|:|||:.|||.||
Zfish   582 CDKRKTLLRGRLYTYMLEKSRVICMPPHQQNFNIFYLMAEGLSAEEKSQLYLNNVLAHRCLN--- 643

Human   649 QDDASTGERSL-------NREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGN 706
              .|:.||...       :||||..||:||..:||:.|||||:||:::|:|||||:|||||.:.:
Zfish   644 --TAAPGESPAVASACPQSREKLLALKQALRALGFNKLEVENVFVLISALLHLGDLRFTALTDAD 706

Human   707 SAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLF 771
            :|||||||||::||||||||:::|:||||:|:|.||||:|.||||::::...||||.|:||.|||
Zfish   707 TAFVSDLQLLDRVAGMLQVSSEDLSSALTSDVQCFKGDVITRRHTVEMSNHHRDLLTKALYGRLF 771

Human   772 SFLVNTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHE 836
            |.|||.:|..|...:|......|:|.|||||||||||:|.:||||:||.||::|.:..||||..|
Zfish   772 SLLVNNINFYLQGHEETTGDPALEISILDIFGFEEFQRNAYEQLCINMVNERIHQFTAEVLFQQE 836

Human   837 QVECVQEGVTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNT 901
            |.||:||||.|||..|.|:|..|||||||||.|.|.::|||||.:...|.|..|:||..|:||.|
Zfish   837 QHECLQEGVAMETLRSLGSQTAVLDFFFQKPQGVLCIIDEESQSLRPCEVNLYKRLQIQLDSSAT 901

Human   902 NAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINH 966
            :||....||||||...||.|.:||:.|:||::.||:.|::::|||.|.||:||||||||||:|:.
Zfish   902 DAVSLTTKDGNGNPPPKDQGPSFTVTHFAGKMTYDLTGSLDRNKDVLPQNILFVMKTSENVLIHQ 966

Human   967 LFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRLE 1031
            :||.||:||||||..:...|.||.|..|::|..|.:. ..:.|.|:||:|||||||.|:||||||
Zfish   967 MFQCKLTQTGSLVPQHQRMKLRGPKGTLINKSTTLNP-ARDAKKYVELNKLLKKKGASSFLQRLE 1030

Human  1032 RGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIF 1096
            |..|:|:|.||:.||.:|..|||.||||||.|:||||:..||.||:|:||:||||:||||||::.
Zfish  1031 RCGPITVAVQLKNSLCEITSKLQSCTPHFIQCVRPNNASKPDVFDSFHVSSQLQYVGVLEMVRMI 1095

Human  1097 RYGYPVRLSFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQ 1161
            |||||||||||.|||||:.|.||.:.::|:.:..|:||.:|..|||||||||..||||:||.||.
Zfish  1096 RYGYPVRLSFSSFLSRYRELVDTIITDRKKATTEEKCRHILLHCKLQGWQMGNSKVFLRYWQADH 1160

Human  1162 LNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNA 1226
            |||.|.||.||||.||||:||:||||.:.:|::.|:||:.::..|||..||:||:|||.||||||
Zfish  1161 LNDRCHQLHRKIIICQKVMRGWLARQQVRRRLTSRKQELCNVQRFLQGAEDLGLRTYDNLVIQNA 1225

Human  1227 SDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGP-------------RHFHPSSMSV 1278
            :||||||||||..::||...|:.|....:|:..||..:|||.             |||..||:.:
Zfish  1226 ADIARENDRLRGHISAPPLGERPEPVGKEEDSPKRVVEKSGRGNDVANRGGNRPIRHFRSSSVPL 1290

Human  1279 CAAVDGLGQCLVGPSI---WSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSAC 1340
            ...:|.|....:|.||   ..|:.||. ...:..||.|||||||||||||||||||||||||||.
Zfish  1291 PLVMDSLVHSSIGASIKAALQPTPHST-DEGNGGSLSSPRKQPPPKPKRDPNTRLSASYEAVSAG 1354

Human  1341 LSAARE-------------------AANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYE 1386
            ||.|.:                   :.:::||:||||||||||||||||.||||||||||:||||
Zfish  1355 LSIAPKDSPAEGQASPSGSPPNTQLSPSDSLAKPRPHSDDYSTMKKIPPPKPKRSPNTKLTGSYE 1419

Human  1387 EISGSRPGDARPAGAP-----------GAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGH 1440
            ||  |.|..|||....           |...|..:...|..::....|..||:|   |||||:|.
Zfish  1420 EI--SVPSPARPTDMKLVSLVRGGHCLGLIQRAASADGPHSSVLSLYPCQDEED---VYIEMVGA 1479

Human  1441 A-----ARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASP-----PLLH-RAP-------- 1486
            :     |...||:|||:|||||| ..|:|.............:|     |:|. :.|
Zfish  1480 SRALSLADTHSPEPGEAVYEEMK-YFPNDEIVSTPVVKPEAVNPTPLPAPVLEIKRPVTLIEQSG 1543

Human  1487 --EDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLK 1549
              ..:..|..|..||||.|||||||||||||||||:|||||||||||||||||||||||.||||.
Zfish  1544 TLGGKQQGKDGMPCDIPAPFPNLLPHRPPLLVFPPSPVTCSPASDESPLTPLEVKKLPVFETNLN 1608

Human  1550 YPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAH 1614
            |..| :|.|||||||:: |:.|    :||.|::.. ..:::||.||||||||...|| ||||.:|
Zfish  1609 YSSQ-DGGSPLSPQYTR-QRAD----SSPSLSILM-PDKSTPPLTPPPPPPPAVLPP-PYRPPSH 1665

Human  1615 LAFPPEPAPVNAGKAG--PSAEAPKV-HPKPNSAPVAGPCSSFPKIPYSPVKATRADARKAGSSA 1676
            ..|||||..:...:|.  .|.|:||| |...:......|.||.|  |:||||.:|.:.|:|.|.:
Zfish  1666 FPFPPEPNFLALTRAASVASTESPKVSHKMGHGLAETPPSSSKP--PFSPVKTSRPEPRRAHSCS 1728

Human  1677 SPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEIT 1741
            |.|..::|.:.|||:||||||.::|:||||:||||..|||||::....:|:|:..|:|......:
Zfish  1729 SSPLLFNPANGRPLTSPLDELNTIFSSGRSLLRKSTTGRKIRDSGLSNSNINLPGREDQGPISPS 1793

Human  1742 SETQDRNANNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQV 1806
            ::.||:|||||   .|.:.|:....||||.||||..|::|:.:...|  .:||..||.|||.|||
Zfish  1794 AQLQDKNANNH---TSPNSSNPAPIENGNQISNGTLEDEGHPKPMAS--SSSTLHRHMDSHHTQV 1853

Human  1807 IHQLRLSENESVALQELLDWRRKLCEEGQDWQQILHHAEP----RVPPPPPCKKPS 1858
            ..:.|....:...|||||.|||.:|:...|||....|...    .|....|.||.|
Zfish  1854 PQRSRACGEQRATLQELLRWRRSVCDGRPDWQNAWLHTNTSPTLTVKTKSPRKKAS 1909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO16	NP_001185879.1	ANKYR	81..332	CDD:223738	170/250 (68%)
		ANK repeat	86..112	CDD:293786	20/25 (80%)
		ANK	89..190	CDD:238125	77/100 (77%)
		ANK repeat	114..145	CDD:293786	23/30 (77%)
		ANK	142..297	CDD:238125	102/154 (66%)
		ANK repeat	147..178	CDD:293786	21/30 (70%)
		ANK repeat	180..210	CDD:293786	20/29 (69%)
		ANK repeat	243..274	CDD:293786	20/30 (67%)
		ANK repeat	276..307	CDD:293786	21/30 (70%)
		ANK repeat	309..335	CDD:293786	16/25 (64%)
		MYSc	426..1165	CDD:214580	442/745 (59%)
		MYSc_Myo16	437..1155	CDD:276844	426/724 (59%)
		NYAP_N	1253..1590	CDD:292079	186/403 (46%)
myo16	XP_001920958.3	ANK	88..186	CDD:238125	75/97 (77%)
		Ank_2	90..177	CDD:289560	64/86 (74%)
		ANK repeat	113..144	CDD:293786	23/30 (77%)
		Ank_2	118..273	CDD:289560	103/154 (67%)
		ANK	141..296	CDD:238125	102/154 (66%)
		ANK repeat	146..207	CDD:293786	42/60 (70%)
		ANK repeat	242..273	CDD:293786	20/30 (67%)
		Ank_2	247..329	CDD:289560	53/81 (65%)
		ANK repeat	275..306	CDD:293786	21/30 (70%)
		MYSc	424..1164	CDD:214580	442/745 (59%)
		Motor_domain	435..1154	CDD:277568	426/724 (59%)
		NYAP_N	1252..1641	CDD:292079	186/402 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I28106
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H34710
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25137at33208
OrthoFinder	1	1.000	-	-		FOG0010550
OrthoInspector	1	1.000	-	-		oto51675
orthoMCL	1	0.900	-	-		OOG6_117464
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6840
SonicParanoid	1	1.000	-	-		X8040
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	12	12.350