DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO16 and Myo16

DIOPT Version :9

Sequence 1:	NP_001185879.1	Gene:	MYO16 / 23026	HGNCID:	29822	Length:	1880	Species:	Homo sapiens
Sequence 2:	XP_006508841.1	Gene:	Myo16 / 244281	MGIID:	2685951	Length:	1941	Species:	Mus musculus

Alignment Length:	1957	Identity:	1467/1957 - (74%)
Similarity:	1631/1957 - (83%)	Gaps:	93/1957 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSHYHFIKCCCFQLCNVFRSHEMEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKAFQKQEG 65
            ||.|||||.||:||||||||||||||||||||||||||||||||||||||||||||||.||||||
Mouse     1 MSQYHFIKYCCYQLCNVFRSHEMEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKVFQKQEG 65

Human    66 FLKRLKHAKNPKVHFNLTDMLQDAIIHHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFI 130
            .|||.|..|..||.|.|.||:|||:|||:|||||:|||||||||||||||||||||||||||.||
Mouse    66 PLKRSKPGKRQKVRFGLADMIQDAVIHHHDKEVLQLLKEGADPHTLVSSGGSLLHLCARYDNVFI 130

Human   131 AEILIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESS 195
            ||:||||||||||||||||||||||||||||||||||:||||||.||||||||||||||||||||
Mouse   131 AEVLIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLILAGANVFLQDVNGNIPLDYAVEGTESS 195

Human   196 SILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVV 260
            :|||.||||.||||:||||:|||||:||||||:|||||||:||||||:|||||||||||||||||
Mouse   196 AILLAYLDEKGVDLSSLRQIKLQRPLSMLTDVRHFLSSGGDVNEKNDDGVTLLHMACASGYKEVV 260

Human   261 SLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEM 325
            .|:||||||||..||:||||||||||||||.||||||.|||||||||||.||.|||||||.||||
Mouse   261 LLLLEHGGDLNGTDDRYWTPLHLAAKYGQTTLVKLLLAHQANPHLVNCNGEKPSDIAASESIEEM 325

Human   326 LLKAEIAWEEKMKEPLSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEKDIMFKDAT 390
            ||||||||||||||..||.:|||||.| ||:||||.|||||||||||||||||||||||||||.|
Mouse   326 LLKAEIAWEEKMKESPSAPSLAQEELY-EILHDLPDLSSKLSPLVLPIAKQDSLLEKDIMFKDTT 389

Human   391 KGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDDLATLSELNDGSLLYEIQKRFGNNQIYTF 455
            ||||||:|||..||..|.|...|||||::|||||:|||||||||||.||||||||||||:||:||
Mouse   390 KGLCKQESQDGPPETSMTSNCGKPEQVQVMPPAPSDDLATLSELNDSSLLYEIQKRFGNDQIHTF 454

Human   456 IGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGE 520
            ||||.|||||:|||||||:||||:|.|.:|:...|||||||||.|||||:||:|::||..|||||
Mouse   455 IGDIFLLVNPFKELPIYSTMVSQMYLSPTGQRSPSLPPHLFSCAERAFHRLFQERKPQNIILSGE 519

Human   521 RGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCE 585
            |||||::|||||:::||.||.:|....|||.:|.:.|:|||||||||||::|||.|:|:|||.|:
Mouse   520 RGSGKTQASKQIMKYLTSRASSSCTMFDSRLRHAIYIVEAFGHAKTTLNNVSSCLIQYWELQCCQ 584

Human   586 RKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNLCAHRYLNQTIQD 650
            |::.:|||||.||:|||||:|:||.||..||||..||||||:|||.||||||.|||||::|.:::
Mouse   585 RRKHITGARISTYMLEKSRVVAQPPGQGTFLIFSWLMDGLSSEEKCGLHLNNFCAHRYVSQGMRE 649

Human   651 DASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGNSAFVSDLQL 715
            |.||.|.|||:|:||.||.||||:|||:||||||||||:||||:|||:||||.|.:|||||||||
Mouse   650 DVSTAEHSLNKERLAALKHALNVIGFSTLEVENLFVILSAILHIGDIQFTALTEADSAFVSDLQL 714

Human   716 LEQVAGMLQVSTDELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNS 780
            |||||||||||||||||||||||||||||:||||||||:|.|:|||||||||||||.||:||:|.
Mouse   715 LEQVAGMLQVSTDELASALTTDIQYFKGDVIIRRHTIQMAAFYRDLLAKSLYSRLFGFLINTVNC 779

Human   781 CLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGV 845
            ||.:|||.||:|||||||||||||||||||||||||||:|||||||||.|||||.||.|||||||
Mouse   780 CLQNQDEYKSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGV 844

Human   846 TMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKD 910
            .||||.|||||.|||||||||||||.:|||||||:|||.|.|.|:|||.|||||||||||||:||
Mouse   845 AMETACSPGNQAGVLDFFFQKPSGFFSLLDEESQVIWSGEPNLPRKLQGLLESSNTNAVYSPVKD 909

Human   911 GNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQT 975
            ||||||.|..|.|||:|||||||||::.||:|:|||||||||||||||||||||:||||||||||
Mouse   910 GNGNVAFKGQGAAFTVMHYAGRVMYEMGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSQT 974

Human   976 GSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIAS 1040
            |||:|:||||||.||||.||||: ||||::|.||||||||||||||||||||||||||:|.|.||
Mouse   975 GSLISSYPSFKFGGHKSTLLSKR-TASSMVGVNKNYLELSKLLKKKGTSTFLQRLERGEPATAAS 1038

Human  1041 QLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLS 1105
            ||.|||.||..|||:.:||||.||:||.|:||..||:|||||||||:|||.:|::||.|||||.|
Mouse  1039 QLTKSLADITAKLQRGSPHFILCIKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRSGYPVRPS 1103

Human  1106 FSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQ 1170
            |.||||||:|||...|.|.|.|:|.||||||||:|||||||:||.||||||||.|||:||.||||
Mouse  1104 FEDFLSRYEPLASVLLGETKGQAAEERCRLVLQRCKLQGWQIGVHKVFLKYWHVDQLSDLWLQLQ 1168

Human  1171 RKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIARENDR 1235
            |||:||||||||||||||||||:||:|||||||.||||:||||.||||||||||||||||||:||
Mouse  1169 RKIVTCQKVIRGFLARQHLLQRMSIKQQEVTSIKSFLQSTEDMALKTYDALVIQNASDIAREHDR 1233

Human  1236 LRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLH 1300
            ||.|::..||      ||.||||:||.:|:.|.||.|.:|:.|...||.|.|.|.|||...||||
Mouse  1234 LRKEVHTAYH------RNRQEEGTKRAEDQGGCRHVHSNSVPVPMVVDSLAQALTGPSTRPPSLH 1292

Human  1301 SVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTM 1365
            ||||||||:.||||||||||||||||||||||||||||||||||::||.|||.||||||||||||
Mouse  1293 SVFSMDDSTGLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAKDAAGEALTRPRPHSDDYSTM 1357

Human  1366 KKIPPRKPKRSPNTKLSGSYEEISGSRPGDARPAGAPGAAARVLTPGT-----------PQCA-- 1417
            ||||||||||||:||||||||||.    |..||:|..|...|...|||           |||.
Mouse  1358 KKIPPRKPKRSPHTKLSGSYEEIW----GPPRPSGTMGQGGRHQAPGTLSVQWARPDSVPQCTPQ 1418

Human  1418 ----LPPAAPPGD-EDDSEPVYIEMLGHAAR-----PDSPDPGESVYEEMKCCLPDDG-GPGAGS 1471
                ||  .|.|| :||:|||||||:|:|||     .||||.|||||||||..||::| |.|..:
Mouse  1419 LPLHLP--LPQGDYDDDAEPVYIEMVGNAARAGGSETDSPDQGESVYEEMKYILPEEGCGLGMLT 1481

Human  1472 FLLHGASPPLL---HRAPEDEAA----GPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASD 1529
            ||  .|||||.   .:|...|||    .|..|.||||||||||||||||||||||||||.|||||
Mouse  1482 FL--PASPPLFLETRKAIILEAAEGNCQPSKDTCDIPPPFPNLLPHRPPLLVFPPTPVTRSPASD 1544

Human  1530 ESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPST 1594
            ||||||||||||||||||||||||.||||||||||||:||||.|:.||||..:|||..|.|||:|
Mouse  1545 ESPLTPLEVKKLPVLETNLKYPVQSEGSSPLSPQYSKAQKGDNDQLASPGFPVFNGPSRISPPAT 1609

Human  1595 PPPPPPPP--------------------------------GPP--------------PAPYRPCA 1613
            |||||.||                                |||              |||.||..
Mouse  1610 PPPPPGPPPAPCGPPPAPCGPPPAPCGPPPAPCGPPPAPCGPPPAPCGAASASCGVAPAPCRPPT 1674

Human  1614 HLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPYSPVKATRADARKAGSSASP 1678
            |.|||||...|.|.||..:::.|:..|||:||||.||||||.|.||||.|..|||.||..|:.||
Mouse  1675 HFAFPPESVLVTAAKALTNSDLPRTQPKPSSAPVPGPCSSFVKAPYSPGKTARADLRKTSSTFSP 1739

Human  1679 PAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSE 1743
            |:|||||:|||||||||||||||||||||||:||.||:||||||||||||:||||:||:||:.||
Mouse  1740 PSPYSPPNSRPLSSPLDELASLFNSGRSVLRRSAVGRRIREAEGFETNMNLSSRDEPSSSEMASE 1804

Human  1744 TQDRNANNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIH 1808
            ||||||||||.|||:||||.:||||||.::|||.|:||.|||.:||.|||:|||:|:||||||||
Mouse  1805 TQDRNANNHGTQLSSSLSSDVTAENGNPVTNGLAEDDGCSRLCLSGMGTSSFQRNRESHTTQVIH 1869

Human  1809 QLRLSENESVALQELLDWRRKLCEEGQDWQQILHHAEPRVPPPPPCKKPSLLKKPEGASCNRLPS 1873
            ||||||||||||||||||||||||..:.||:.|.|.|||.|||||||||:|||||||.||.||||
Mouse  1870 QLRLSENESVALQELLDWRRKLCEAREGWQEALQHPEPRAPPPPPCKKPTLLKKPEGGSCTRLPS 1934

Human  1874 ELWDTTI 1880
            :|||:::
Mouse  1935 QLWDSSM 1941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO16	NP_001185879.1	ANKYR	81..332	CDD:223738	221/250 (88%)
		ANK repeat	86..112	CDD:293786	21/25 (84%)
		ANK	89..190	CDD:238125	93/100 (93%)
		ANK repeat	114..145	CDD:293786	28/30 (93%)
		ANK	142..297	CDD:238125	137/154 (89%)
		ANK repeat	147..178	CDD:293786	28/30 (93%)
		ANK repeat	180..210	CDD:293786	26/29 (90%)
		ANK repeat	243..274	CDD:293786	26/30 (87%)
		ANK repeat	276..307	CDD:293786	27/30 (90%)
		ANK repeat	309..335	CDD:293786	22/25 (88%)
		MYSc	426..1165	CDD:214580	568/738 (77%)
		MYSc_Myo16	437..1155	CDD:276844	549/717 (77%)
		NYAP_N	1253..1590	CDD:292079	248/367 (68%)
Myo16	XP_006508841.1	PHA03095	92..>313	CDD:222980	197/220 (90%)
		ANK repeat	114..145	CDD:293786	28/30 (93%)
		ANK repeat	147..178	CDD:293786	28/30 (93%)
		ANK repeat	180..210	CDD:293786	26/29 (90%)
		ANK repeat	243..274	CDD:293786	26/30 (87%)
		ANK repeat	276..307	CDD:293786	27/30 (90%)
		MYSc_Myo16	436..1153	CDD:276844	549/717 (77%)
		NYAP_N	1241..1605	CDD:373845	251/377 (67%)
		NYAP_C	1752..>1782	CDD:373858	26/29 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83971266
Domainoid	1	1.000	1131	1.000	Domainoid score	I1256
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34710
Inparanoid	1	1.050	2830	1.000	Inparanoid score	I709
Isobase	1	0.950	-	0	Normalized mean entropy	S4155
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40028
OrthoDB	1	1.010	-	-		D25137at33208
OrthoFinder	1	1.000	-	-		FOG0010550
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_117464
Panther	1	1.100	-	-	LDO	PTHR47335
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6840
SonicParanoid	1	1.000	-	-		X8040
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.390