DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO16 and myo16

DIOPT Version :9

Sequence 1:	NP_001185879.1	Gene:	MYO16 / 23026	HGNCID:	29822	Length:	1880	Species:	Homo sapiens
Sequence 2:	XP_031752902.1	Gene:	myo16 / 100486369	XenbaseID:	XB-GENE-1010948	Length:	1862	Species:	Xenopus tropicalis

Alignment Length:	1889	Identity:	1154/1889 - (61%)
Similarity:	1403/1889 - (74%)	Gaps:	90/1889 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSHYHFIKCCCFQLCNVFRSHEMEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKAFQKQEG 65
            |||||||||||||||||||||:||||||||||||||||||||:||||:|||||||||||.|||:|
Frog     1 MSHYHFIKCCCFQLCNVFRSHDMEIDQCLLESLPLGQRQRLVRRMRCDQIKAYYEREKALQKQDG 65

Human    66 FLKRLKHAKNPKVHFNLTDMLQDAIIHHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFI 130
            :.:|.|..||.||||.|::.:|||||||||||||:|||:|||||.|::|||.||||||||||||.
Frog    66 YKRRSKQRKNCKVHFPLSEKIQDAIIHHNDKEVLQLLKDGADPHILITSGGCLLHLCARYDNAFA 130

Human   131 AEILIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESS 195
            |||||||||:||||||:.|||||:|||||||||||||:|:||||||||:||||.||||||||||.
Frog   131 AEILIDRGVHVNHQDEELWTPMHVACACDNPDIVLLLLLSGANVLLQDINGNIALDYAVEGTESR 195

Human   196 SILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVV 260
            ||||.||:|||:||:|||||::||.|.||:|:|..:::||:|:|||||||||||:|||.|||:|.
Frog   196 SILLAYLEENGIDLSSLRQMRMQRAMVMLSDIKQLVATGGSVSEKNDEGVTLLHIACACGYKDVT 260

Human   261 SLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEM 325
            ..:||:|.|.:..||.||||||||||||||:|||:||.|||||:::||||:|.||:|.:|.|::|
Frog   261 CQLLENGADPDSTDDHYWTPLHLAAKYGQTSLVKILLAHQANPNMLNCNEDKPSDVAVTEGIQDM 325

Human   326 LLKAEIAWEEKMKEPLSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEKDIMFKDAT 390
            |||||...:|:.|......|..||||||||.||:|:.::||.||.|||:||||.||||.||||:.
Frog   326 LLKAEHLADERKKNGTPLCTEFQEEPYEEIAHDIPLAANKLRPLALPISKQDSFLEKDTMFKDSG 390

Human   391 KGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDDLATLSELNDGSLLYEIQKRFGNNQIYTF 455
            |.|.| ..|::..|...:|.:||.||:|||||||||||||||||.|.||||||||||.||||||:
Frog   391 KTLSK-IPQETASEKITISSTTKLEQIKLMPPAPNDDLATLSELTDSSLLYEIQKRFNNNQIYTY 454

Human   456 IGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGE 520
            ||:|||||||||.|||||::|:|||.::||:||||||||:|:|.|||:|.||:|:|.||||||||
Frog   455 IGNILLLVNPYKNLPIYSALVTQLYNNNSGRLCSSLPPHIFACSERAYHMLFQERRSQCFILSGE 519

Human   521 RGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCE 585
            .||||:|:.|.|::||..|.|:|:.:|.|:.|||.|||||||||:|::|:.||.||.:.||||||
Frog   520 SGSGKTESCKHIVKHLAFRCGSSKNSLYSKIKHVNCILEAFGHARTSINNSSSRFINFLELQFCE 584

Human   586 RKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNLCAHRYLNQTIQD 650
            :||.|:|||:|||:||||||:|.|.|||||||||.:||||||||||.|:|.:|.|||||||.:.:
Frog   585 KKQTLSGARVYTYMLEKSRLLSYPPGQSNFLIFYFMMDGLSAEEKYSLYLKSLSAHRYLNQNVPE 649

Human   651 DA-STGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGNSAFVSDLQ 714
            |. |....:.|||||..||:||..:|:::||:|||||||:||||:||||||||.:..:|||||||
Frog   650 DTISLSASTQNREKLDNLKQALIALGYNNLEIENLFVILSAILHIGDIRFTALTDAETAFVSDLQ 714

Human   715 LLEQVAGMLQVSTDELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMN 779
            |:||||||||||.|||::||||::||||||||.|||::..|||:|||||||||.||||||||.:|
Frog   715 LIEQVAGMLQVSPDELSAALTTEVQYFKGDMITRRHSVDTAEFYRDLLAKSLYCRLFSFLVNNIN 779

Human   780 SCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEG 844
            ..|..|.:|.|...|.:|||||||||:||||.|||||:|:||||:|.:|.||||..||.||.|||
Frog   780 YYLQQQSDQTSYPPLTVGILDIFGFEDFQKNSFEQLCINLTNEKIHQHITEVLFFQEQTECAQEG 844

Human   845 VTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMK 909
            ::|||.|..||...|||||||||.||:::||||||.|.::|.:..|:||||||:|||||:|...|
Frog   845 ISMETIYCLGNHTTVLDFFFQKPMGFMSVLDEESQSIHTMEHSLSKRLQSLLETSNTNAIYFSSK 909

Human   910 DGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQ 974
            ||||||..||||..|.:|||||||.|::.||.|||||.||||||||||||||:|||.:|||||:|
Frog   910 DGNGNVTSKDHGPTFAVMHYAGRVTYNIFGATEKNKDVLSQNLLFVMKTSENLVINQMFQSKLTQ 974

Human   975 TGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIA 1039
            ||||:..||..|.||.|:|||.||.:|||  ||.|..|||.||:||||:.:|||:||||.|.|::
Frog   975 TGSLIPPYPPLKLRGPKAALLFKKNSASS--GETKKILELGKLIKKKGSYSFLQKLERGGPTTVS 1037

Human  1040 SQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRL 1104
            .|||||..:||||:|..|||.:|||:||::||.:||||||||||||||||||||||.|||||:||
Frog  1038 IQLRKSFTEIIGKVQSSTPHLMHCIKPNSTKLAETFDNFYVSAQLQYIGVLEMVKIIRYGYPIRL 1102

Human  1105 SFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQL 1169
            :|||||||||.|.:....||::.||.|:||.||.|||.||||||.||||||||.||||:|:||||
Frog  1103 AFSDFLSRYKNLVEILAWEKQKTSAEEKCRHVLLQCKQQGWQMGTRKVFLKYWQADQLSDMCLQL 1167

Human  1170 QRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIAREND 1234
            |:|||.||||||.|||||||.:::..::.|.|.|..|:|..|:||.::|.:||||||||||||..
Frog  1168 QKKIILCQKVIRRFLARQHLQKKLDTKENEDTFIKDFIQTIENMGQQSYHSLVIQNASDIAREKV 1232

Human  1235 RLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKS---------GPR---HFHPSSMSVCAAVDGLGQ 1287
            .|:.|.|..|  ..:|....:||..|.|:|..         |.|   ...|.|::|
Frog  1233 ALQIESNTAY--SAMESICNKEEMLKSTEDSDLKPTGNIFVGCRISTLCQPGSITV--------- 1286

Human  1288 CLVGP----SIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAR-EA 1347
             .:.|    :|.|.|||||.||||.:.|.||||||||||||:|.||||||||||||||.||. :.
Frog  1287 -PINPVSSSAIRSLSLHSVLSMDDGNCLQSPRKQPPPKPKRNPTTRLSASYEAVSACLFAASVDI 1350

Human  1348 ANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEISGSRPGD----------------- 1395
            .||||:|||||||||||||||||.|||||||||||.|:||||....|:
Frog  1351 DNEALSRPRPHSDDYSTMKKIPPPKPKRSPNTKLSSSFEEISAHNSGELNTFSTIVRKVHRDIGT 1415

Human  1396 -ARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLG-----HAARPDSPDPGESVY 1454
             .|.|.|.|....:||          .....:||::|||||||.|     |.....||:.||:||
Frog  1416 IQRAASADGPHHGILT----------LCMSEEEDEAEPVYIEMAGTAGKCHFIERSSPEQGEAVY 1470

Human  1455 EEMKCCLPDD---GGPGAGSFLLHGASPPLLHRAPED---EAAGPPGDACDIPPPFPNLLPHRPP 1513
            ||||...||.   .....||.||...:.........|   |....  ::||||.|||||||||||
Frog  1471 EEMKYHHPDHININNLAMGSSLLQNMNLATFENLDADIKNEQCSK--ESCDIPAPFPNLLPHRPP 1533

Human  1514 LLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASP 1578
            ||||||..||.|||||||||||||:.||||||||:.|.:|.:.|||:|.|..|.|: |.:||:||
Frog  1534 LLVFPPATVTSSPASDESPLTPLEMIKLPVLETNINYTIQTDMSSPISSQCLKHQR-DNERPSSP 1597

Human  1579 GLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPA-PVNAGK--AGPSAEAPKVHP 1640
            .|::|:.|.:.|||.|||.|     ..|..::...|.:||.|.: .:..||  ...:|::.|:.|
Frog  1598 ALSVFSVSSKVSPPCTPPLP-----QTPTSFQFPTHFSFPMESSYALLVGKNLKTTNADSVKIAP 1657

Human  1641 KPNSAPVAGPCSSFPKIPY-SPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSG 1704
            |.|:......|.|..|:.: ||:|..|....|: ...||....|..:...::||||||.:||:||
Frog  1658 KSNAVITEESCGSLTKLTFSSPIKNARTMQNKS-HLGSPSLATSLTNISHITSPLDELTTLFSSG 1721

Human  1705 RSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSSAITAENG 1769
            ||:||||||||||||.||.|.|:|:...:|.:    ..:|||.||||...:..||.||....|||
Frog  1722 RSLLRKSAAGRKIREQEGVEMNLNVCGGEDVA----MPDTQDNNANNQDNRGPNSRSSCAAFENG 1782

Human  1770 NSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEG 1834
            ||::||:.|||...:|. :...||:..::::.|:.|||||||||:|||.|||||:||||||||..
Frog  1783 NSVTNGMAEEDLNCKLQ-NTISTSSSTKNKEQHSNQVIHQLRLSKNESAALQELMDWRRKLCEGN 1846

Human  1835 QDWQ 1838
            .:||
Frog  1847 GEWQ 1850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO16	NP_001185879.1	ANKYR	81..332	CDD:223738	184/250 (74%)
		ANK repeat	86..112	CDD:293786	21/25 (84%)
		ANK	89..190	CDD:238125	85/100 (85%)
		ANK repeat	114..145	CDD:293786	27/30 (90%)
		ANK	142..297	CDD:238125	113/154 (73%)
		ANK repeat	147..178	CDD:293786	25/30 (83%)
		ANK repeat	180..210	CDD:293786	24/29 (83%)
		ANK repeat	243..274	CDD:293786	18/30 (60%)
		ANK repeat	276..307	CDD:293786	24/30 (80%)
		ANK repeat	309..335	CDD:293786	14/25 (56%)
		MYSc	426..1165	CDD:214580	505/739 (68%)
		MYSc_Myo16	437..1155	CDD:276844	487/718 (68%)
		NYAP_N	1253..1590	CDD:292079	186/382 (49%)
myo16	XP_031752902.1	ANKYR	81..316	CDD:223738	174/234 (74%)
		ANK repeat	119..145	CDD:293786	23/25 (92%)
		ANK repeat	147..178	CDD:293786	25/30 (83%)
		ANK repeat	180..210	CDD:293786	24/29 (83%)
		ANK repeat	243..274	CDD:293786	18/30 (60%)
		ANK repeat	276..307	CDD:293786	24/30 (80%)
		ANK repeat	309..339	CDD:293786	15/29 (52%)
		MYSc_Myo16	436..1153	CDD:276844	487/718 (68%)
		NYAP_N	1243..1620	CDD:406008	194/404 (48%)
		NYAP_C	1677..>1738	CDD:406017	32/61 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1011	1.000	Domainoid score	I637
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H34710
Inparanoid	1	1.050	2156	1.000	Inparanoid score	I559
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22691at32523
OrthoFinder	1	1.000	-	-		FOG0010550
OrthoInspector	1	1.000	-	-		oto157448
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060