Protein Alignment UNC13A and YOR296W

DIOPT Version :10

• Sequence 1: NP_001073890.2
• Gene: UNC13A / 23025
• HGNCID: 23150
• Length: 1703
• Species: Homo sapiens
• Sequence 2: NP_014939.1
• Gene: YOR296W / 854471
• SGDID: S000005822
• Length: 1289
• Species: Saccharomyces cerevisiae
• Alignment Length: 1150
• Identity: 209/1150 - (18%)
• Similarity: 358/1150 - (31%)
• Gaps: 427/1150 - (37%)

Human   588 GVKCHEKCQDLLNADCLQRAA----EKSSKH----------------------GAEDR----TQN 622
            |:...::|.:.:||..|.:.|    .||:::                      |.|:.    |:|
Yeast   358 GLVLKKECSNAVNAINLSQEALFFFHKSARYWRIEYPSTISSLVYSAANLSVLGDEELNIPITEN 422

Human   623 IIMVLKDRMKIRERN-KPEIFELIQEIFAVTKTAHT--QQMKAVKQ---SVLDGTS-KWSAKISI 680
            :..|::::....|.| .|..:.............||  |.|:.:..   ::..||. |:|..:|.
Yeast   423 LFSVIRNKYLCSEDNLDPSAWNAQDRYLWAANLFHTTDQSMRTINNLLTAIFSGTKPKFSPVLSF 487

Human   681 TVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNL--NPVWEENFHFECHNSSDRIKVRVW 743
                                              .|.|:  :||.|  |:   ...|..:| :.|
Yeast   488 ----------------------------------YYSNIVGDPVME--FY---ETQSVAVK-KYW 512

Human   744 DEDDDIKSRVKQRFKRESDDF--------------------LGQTIIEV---------RTLSGEM 779
                 ||...|..||...|.|                    |.:||||.         :.|..|:
Yeast   513 -----IKLFKKTLFKASEDYFVSLLQDMLKANAIEIQNVQNLVETIIEAIKAIQKRYNKPLLDEI 572

Human   780 -----------DVW----YNLDKRTDKSAVS------GAI-------------RLHISVEIKGE- 809
                       :|:    .||.|..:||.:.      |.|             ::::.|:.||:
Yeast   573 SLPRQCAVFLCEVYGSDSLNLIKTAEKSTMKMTGQKLGPIDALDMYDVLKELRQIYLQVKPKGKF 637

Human   810 -EKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDET--AQEIVDEFAM---- 867
             ..:..|.::|      |.....||..|....|..:...:.|:...|:.  ::.::|.|.|
Yeast   638 FFNLENYFIKY------LTRLCDDVSRNVQKVIKSSLESENWQPVNDQDHFSRSVLDIFKMINES 696

Human   868 -----RYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANI--------NAYYAHTTASTNVSA 919
                 ::|.::.:| :.....:..|....|:.:..:.|:..|        ...|:..::.|..|.
Yeast   697 TSMLEKFGWQNEFQ-LAQMITVILKAFSDGMLSYSAQLMELIQRDLQEGDEPSYSLESSDTRSSL 760

Human   920 SDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPER--------LQDLKSTVDLLTSI 976
            |...|..|..|.|..:|.:.|.|.::....|.     |.:|.:        |.||..|:.||.|.
Yeast   761 SLNNANVNHEKSRSSRLFEDLKNVVKSTPKMV-----APAPYQFKKRTCVLLNDLDKTLFLLESF 820

Human   977 TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPS 1041
                   :|...|.:.|.|:..             :::.|.|                 |:.|.|
Yeast   821 -------EEKADPSKISSVIAQ-------------YHSSHNL-----------------EDNGKS 848

Human  1042 IKNLDFWSKLITLIVSIIEEDK--------NSYTPCLN-QFPQELNVGKISAEVMWNLFAQDMKY 1097
            ..:.:. .::.||.:...|..|        |:|....| ...:|:...||.|.
Yeast   849 FDDQNM-KQVYTLRIIGAENIKGFSKTGLSNTYVSMRNITLQREIGTTKIVAR------------ 900

Human  1098 AMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRD 1162
                               ....|| ..|:|.|.|..|.....:..|..|
Yeast   901 -------------------SITPKW-DEEFVFESPFGKSNDIMFTIWHHP--------------- 930

Human  1163 FLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISN 1227
              |..|:...:|                |:..:.|..|...|..:...|
Yeast   931 --HSRLKNLAED----------------DLCGKANMKFTPRKLKDDGFP---------------- 961

Human  1228 VLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVK 1292
              :.::..::.....||                |:.::.||         :||.:|
Yeast   962 --IDFSLTLNPQGTLYC----------------QISLESEK---------IDAVSS--------- 990

Human  1293 LNNVLDELSRVFATSFQPHIEECVKQMGDIL------SQVKGTGNVPASACSSVAQDADNVLQPI 1351
                :..:.|.|:.|....|...|.:..|.:      :.:|.......||.:|.....|.:| |:
Yeast   991 ----MGRIYRSFSRSRDRAINLIVNKFSDFIAFAFSRTTLKTVCGHHGSALASDEAVYDAIL-PL 1050

Human  1352 MDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGR 1416
            .|.|::||.:.|....:.:|..|:...|.||:...: .::||.|....:  |:||
Yeast  1051 FDYLNANLNILASELSQRLLFMVMLRAWNLVLENAD-LLLLPALNSAKV--NILR---------- 1102

Human  1417 VKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTI-KQYFHAGGVGL 1480
                          :|.|.|.:.:......|....:.||..:...|...||.: ..:||..|.|
Yeast  1103 --------------SAKKSLWENTLSTTKTVSGYGRPLTQAEIEAVFKWLDALCVDFFHNKGEG- 1152

Human  1481 KKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGE-VSVHVE--------- 1535
                    |.|..|:   :.|.| ..|||..|.....::   ::|.|.. :.::.|
Yeast  1153 --------PPLAELK---NEYYQ-NILLIPAFYDKSVSE---LKDEVQRLIPLYEEYLRWFYLKK 1202

Human  1536 ---LFTHPGTGEHKVTV---KVVAANDLKWQTSGIFRPFIEVNII 1574
               .||:...|    |:   |.:.||.:|.....:.|....:|||
Yeast  1203 TPITFTNKSAG----TISRKKSLVANIVKEPKEQLERDAEVMNII 1243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC13A	NP_001073890.2	C2A_Munc13	1..127	CDD:176040
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..445
		C1_Munc13-2-like	535..616	CDD:410409	8/53 (15%)
		C2B_Munc13	676..802	CDD:175993	32/190 (17%)
		MUN	994..1512	CDD:461870	92/533 (17%)
		C2C_Munc13	1546..1665	CDD:176041	8/31 (26%)
YOR296W	NP_014939.1	C2_Munc13_fungal	856..986	CDD:176008	33/237 (14%)