Protein Alignment UNC13A and PKC1

DIOPT Version :10

• Sequence 1: NP_001073890.2
• Gene: UNC13A / 23025
• HGNCID: 23150
• Length: 1703
• Species: Homo sapiens
• Sequence 2: NP_009445.2
• Gene: PKC1 / 852169
• SGDID: S000000201
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 972
• Identity: 163/972 - (16%)
• Similarity: 307/972 - (31%)
• Gaps: 349/972 - (35%)

Human   143 KKLEQLNAMRDQDEYSFQDEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSAVDDRDSDYRSETSN 207
            |||....|.:.|.|...:|          |:.||...:|
Yeast    59 KKLRLKTAQQSQGENGSED----------NERCNSKEYG-------------------------- 87

Human   208 SIPPPYYTTSQPNASVH------QYSVRPPPLGSRESYSDSMHSYEEFSEPQALSPTGSSRYASS 266
                 :.:|..||..:.      :|..  |.|..|..|   |....||            :....
Yeast    88 -----FLSTKSPNEHIFSRLDLVKYDC--PSLAQRIQY---MLQQLEF------------KLQVE 130

Human   267 GELSQGSSQLSE--DFDPDEHS---LQGSDMEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEE 326
            .:..:.:::|::  ..|.|:.|   .:|..||.:     |..                  :.|.:
Yeast   131 KQYQEANTKLTKLYQIDGDQRSSSAAEGGAMESK-----YRI------------------QMLNK 172

Human   327 DLEDFLEEEELPEDEEELEEEEEEVPDDLGSYAQRED------VAVAEPKDFKRISLPPAAPGKE 385
            .|:.:   :.:..|.::.:.:..::.|:.....:|:.      :.:...:|...|..|..|...|
Yeast   173 ALKKY---QAINVDFDQFKHQPNDIMDNQQPKFRRKQLTGVLTIGITAARDVDHIQSPMFARKPE 234

Human   386 DKAPVAPTEAPDMAKVAPKPATPDKVPAAEQIP-----EAE---PPKDEESFRP----------- 431
            ....:   :..|..|...||:..|:.....|||     |.|   ..|..:|..|
Yeast   235 SYVTI---KIDDTIKARTKPSRNDRWSEDFQIPVEKGNEIEITVYDKVNDSLIPVAIMWLLLSDI 296

Human   432 ----REDEEGQ-------------EGQDSMSRAKANWLRA-FNKVRMQLQEAR---GE----GEM 471
                |:.:.||             .|..|::..:.:.|.: ::...:|...|:   ||    .::
Yeast   297 AEEIRKKKAGQTNEQQGWVNASNINGGSSLASEEGSTLTSTYSNSAIQSTSAKNVQGENTSTSQI 361

Human   472 SKSLWFKGGPGGGLI-------------------------IIDSMPDIRKRKPIPLVSDLAMSLV 511
            |.:.||...|.|.::                         ||:...:|.::.....|.....:::
Yeast   362 STNSWFVLEPSGQILLTLGFHKSSQIERKQLMGGLHRHGAIINRKEEIFEQHGHHFVQKSFYNIM 426

Human   512 QSRKAG-------------------------ITSALA--SSTLNNEELK-NHVYKKTLQALIYPI 548
            .....|                         :|..:|  |:..:.:|.| ||
Yeast   427 CCAYCGDFLRYTGFQCQDCKFLCHKKCYTNVVTKCIAKTSTDTDPDEAKLNH------------- 478

Human   549 SCTTPHNFEVWTATTPTYCYECEGLL-WGIARQGMR-CTECGVKCHEKCQDLLNADCLQRAAEKS 611
              ..||.|...:.....:|..|..:| ||  |..:| |:|||:.||.:|..|: .|....:.|.:
Yeast   479 --RIPHRFLPTSNRGTKWCCHCGYILPWG--RHKVRKCSECGIMCHAQCAHLV-PDFCGMSMEMA 538

Human   612 SKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSA 676
            :|         |:..::|..:.:|:.|              :|..:.|:.: .....:|:....:
Yeast   539 NK---------ILKTIQDTKRNQEKKK--------------RTVPSAQLGS-SIGTANGSDLSPS 579

Human   677 KISITVVCAQGLQAK--DKTGSS----------------DPYVTVQVGKTKKRTKTI-----YGN 718
            |::.........|.:  |||.|.                |..:::|....:|..|.|     |.|
Yeast   580 KLAERANAPLPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRISLQTHGREKLNKFIDENEAYLN 644

Human   719 LNPVWEENFHFECHN-----SSDRIKV----------RVWDEDDDIKSRVKQRFKRESDDFLGQT 768
            .....::...|....     :|:|..:          :.|:..||:.....:.:|.:.::.
Yeast   645 FTEGAQQTAEFSSPEKTLDPTSNRRSLGLTDLSIEHSQTWESKDDLMRDELELWKAQREEM---- 705

Human   769 IIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEI--------KGEEKVAPYHVQYTCLHEN 825
            .:|::..|||:.....:|              ||.:|.        |.:.:.|...:..|  |.|
Yeast   706 ELEIKQDSGEIQEDLEVD--------------HIDLETKQKLDWENKNDFREADLTIDST--HTN 754

Human   826 LFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMC 890
            .|.   |:.:            :.:::..|..::|::.|      ..|:....||    :|:...
Yeast   755 PFR---DMNS------------ETFQIEQDHASKEVLQE------TVSLAPTSTH----ASRTTD 794

Human   891 PGVPAVMSTLLANINAYYAHTTASTNVSASDRF------AASNFGKERFVKLLDQLHNSLRI 946
            ...|....|   :.:|.:....|.....:.|.|      ...||||    .:|.:..|:.|:
Yeast   795 QQSPQKSQT---STSAKHKKRAAKRRKVSLDNFVLLKVLGKGNFGK----VILSKSKNTDRL 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC13A	NP_001073890.2	C2A_Munc13	1..127	CDD:176040
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..445		47/311 (15%)
		C1_Munc13-2-like	535..616	CDD:410409	22/82 (27%)
		C2B_Munc13	676..802	CDD:175993	25/163 (15%)
		MUN	994..1512	CDD:461870
		C2C_Munc13	1546..1665	CDD:176041
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011	5/12 (42%)
		HR1_PKC-like_2_fungi	110..181	CDD:212010	17/111 (15%)
		C2_fungal_Pkc1p	211..319	CDD:176071	21/110 (19%)
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	3/50 (6%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	20/75 (27%)
		STKc_PKC	828..1145	CDD:270722	7/26 (27%)