Protein Alignment UNC13A and unc13a

DIOPT Version :10

• Sequence 1: NP_001073890.2
• Gene: UNC13A / 23025
• HGNCID: 23150
• Length: 1703
• Species: Homo sapiens
• Sequence 2: XP_068072457.2
• Gene: unc13a / 568618
• ZFINID: ZDB-GENE-140722-1
• Length: 1814
• Species: Danio rerio
• Alignment Length: 1841
• Identity: 1412/1841 - (76%)
• Similarity: 1529/1841 - (83%)
• Gaps: 173/1841 - (9%)

Human     1 MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVW 65
            ||||||||||||.||.||||||||:||||||||||||||||||.|||||||||||||||||||||
Zfish     1 MSLLCVGVKKAKLDGPQEKFNTYVSLKVQNVKSTTIAVRGSQPCWEQDFMFEINRLDLGLTVEVW 65

Human    66 NKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQVIMADSEICGTKDPTFHRILLDTRFELP 130
            ||||||||||||:||||.:||||||||||:|||||:|||||::||||||||||||:|||||||||
Zfish    66 NKGLIWDTMVGTLWIPLSSIRQSNEEGPGQWLTLDAQVIMAENEICGTKDPTFHRVLLDTRFELP 130

Human   131 LDIPEEEARYWAKKLEQLNAMRDQDEYSFQDEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSAVD 195
            ||||||||||||||||||||||||| |:||:|.::|||:||.|||||:.  ||:|.|||||||||
Zfish   131 LDIPEEEARYWAKKLEQLNAMRDQD-YTFQEEHERPLPMPSTQCCNWSL--WGDQQNDDPDSAVD 192

Human   196 DRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPQAL----- 255
            |||||||||||||||||:|||||||||:|||.:|....|||  |:: ||.| ::...:|:
Zfish   193 DRDSDYRSETSNSIPPPFYTTSQPNASMHQYPIRQMQHGSR--YNE-MHDY-DYDNQRAIRRYDS 253

Human   256 -----------------------------------SPTGSSRYASSGELSQGSSQLSEDFDP-DE 284
                                               |||||||||||||||:|||||||:|.| |.
Zfish   254 LDSATNGRSDLDSASGSSRRTSRQYSLDSRHSLSDSPTGSSRYASSGELSRGSSQLSEEFGPEDG 318

Human   285 HSLQGS-DMEDERDRDSYHSCHSSVSYHKDSPRWDQDEEE-------------------LEEDLE 329
            .|.:|| :..||  .||||||||||||.|:||.||.||.:                   .:|:.|
Zfish   319 ESFRGSGEFYDE--NDSYHSCHSSVSYGKESPGWDPDEPQGVYSDDGEYNKDGGEEGALYDEEGE 381

Human   330 DFLEEE-ELPEDEEE----LEEEEEEVPDDLGSYAQRE-----------------DVAVAEPKDF 372
            .:.::| |.|.:|||    .||:|:..|.| |:.::.:                 |...:.|...
Zfish   382 IYEQDEGEYPYEEEEEGMVYEEDEDLYPLD-GTLSEEQEPPYTPTPTSTAPTLAPDALTSRPPLE 445

Human   373 KRISLPPAAPG-----------KEDKAPVAPTEAPDMAKVAPKPAT--------PDKVPA----- 413
            |:.|:....|.           |.:..|  |.:..|:....|:..|        |:|||.
Zfish   446 KQASMHQQQPSQSQIPFQPMEPKRESPP--PQQTHDVFAKVPRTTTPPQISDTEPEKVPTPPGNG 508

Human   414 ---AEQIPEAE----PPKDEESFR---PREDEEGQEGQDSMSRAKANWLRAFNKVRMQLQEARGE 468
               ||.:....    |||.|:..:   |....:.:...|...||||||||.||:||:||||||||
Zfish   509 PAYAEDLLSTSTTEIPPKAEQEKKEALPESISKQEPPVDPAIRAKANWLRLFNRVRLQLQEARGE 573

Human   469 GEMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQ-SRKAGITSALASSTLNNEEL 532
            .....||:.:.||||.|..||||||:||||.||||.||  |||| |||||||||:||||||||||
Zfish   574 TPGLASLFLQAGPGGALYSIDSMPDLRKRKAIPLVRDL--SLVQNSRKAGITSAMASSTLNNEEL 636

Human   533 KNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQD 597
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   637 KSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQD 701

Human   598 LLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFAVTKTAHTQQMKA 662
            |||||||||||||||||||||||||||||||||||||||||||||||||::|||.|..|..|||.
Zfish   702 LLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQDVFAVIKATHVAQMKQ 766

Human   663 VKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENF 727
            :|||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||:|:|
Zfish   767 IKQSVLDGTSKWSAKISITVLCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWDESF 831

Human   728 HFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKS 792
            :|||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||
Zfish   832 NFECHNSSDRIKVRVWDEDDDIKSRVKQKFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKS 896

Human   793 AVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDET 857
            |||||||:||||||||||.|||||||||||||||||::||:||||||||||||||||||||::||
Zfish   897 AVSGAIRMHISVEIKGEETVAPYHVQYTCLHENLFHYLTDIQNNGVVKIPDAKGDDAWKVYFEET 961

Human   858 AQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTT-ASTNVSASD 921
            .|||||||||||||||||||||||||||||||||||||||||||||||||||||| |:.||||||
Zfish   962 PQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTQATNNVSASD 1026

Human   922 RFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQEL 986
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1027 RFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQEL 1091

Human   987 QSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKL 1051
            |||||||||||||||||||||||||||||||||||||||||.|||||.|||||||||||||||||
Zfish  1092 QSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPNKKGEVPPEEQGPSIKNLDFWSKL 1156

Human  1052 ITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNL 1116
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|:|||||||||||
Zfish  1157 ITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHEKNRLCKSADYMNL 1221

Human  1117 HFKVKWLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSE 1181
            |||||||||||..:||.||.||||||.||||||||||||||||||||||||||||||||:|||||
Zfish  1222 HFKVKWLYNEYCKDLPFFKSRVPEYPTWFEPFVIQWLDENEEVSRDFLHGALERDKKDGYQQTSE 1286

Human  1182 HALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFASYCSK 1246
            |||||||||||||||||||||||||||||||||||||:|||||||||||.||||||:||.::|:|
Zfish  1287 HALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMKRFAKTISNVLLSYADIISRDFPNHCTK 1351

Human  1247 EKEKV------PCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFA 1305
            ||...      ||||:||.|||||||||||||||||:|:.||||||||||:|||||||:|:|:||
Zfish  1352 EKVNAKDGAVKPCILINNIQQLRVQLEKMFEAMGGKDLNVEASDILKELQLKLNNVLDDLARIFA 1416

Human  1306 TSFQPHIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTV 1370
            |||||:|||.||||||||||||||||||||||||||||||||||||||.||||||||||||||||
Zfish  1417 TSFQPNIEENVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDFLDSNLTLFAKICEKTV 1481

Human  1371 LKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGRVKLPSHSDGTQMIFNAAKE 1435
            |||||||||||||||||||||||||||||               |||||..||||||:|||||||
Zfish  1482 LKRVLKELWKLVMNTMEKTIVLPPLTDQT---------------GRVKLACHSDGTQLIFNAAKE 1531

Human  1436 LGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSL 1500
            ||||||||:||||||||:|:||||||:||||||||||||||||||||||||||||||||.|||||
Zfish  1532 LGQLSKLKEHMVREEAKALSPKQCAVIELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLHYALSL 1596

Human  1501 YTQATDLLIKTFVQTQSAQ-------------------GLGVEDPVGEVSVHVELFTHPGTGEHK 1546
            ||||||.|||||||:|:.|                   |.||:|.|||||:|||:||||.|||||
Zfish  1597 YTQATDKLIKTFVQSQNTQVHGGKGVRFTQSEDVYPEKGTGVDDAVGEVSIHVEIFTHPNTGEHK 1661

Human  1547 VTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADAG 1611
            |||||||||||:||||||||||:||.||||.|||||||:|||||||||||||||:|.||||.:.|
Zfish  1662 VTVKVVAANDLRWQTSGIFRPFVEVYIIGPHLSDKKRKYATKSKNNSWAPKYNETFTFTLSNEVG 1726

Human  1612 PECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRS 1676
            |||||||||||||||||||||||:|||||:::|.|||.|||||||:|||||:||||||||||||:
Zfish  1727 PECYELQVCVKDYCFAREDRTVGMAVLQLKDVAPRGSVACWLPLGKRIHMDETGLTVLRILSQRN 1791

Human  1677 NDEVAKEFVKLKSDTRSAEEG 1697
            ||:|||||||||||.||||||
Zfish  1792 NDDVAKEFVKLKSDQRSAEEG 1812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC13A	NP_001073890.2	C2A_Munc13	1..127	CDD:176040	113/125 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..445		133/375 (35%)
		C1_Munc13-2-like	535..616	CDD:410409	80/80 (100%)
		C2B_Munc13	676..802	CDD:175993	119/125 (95%)
		MUN	994..1512	CDD:461870	460/523 (88%)
		C2C_Munc13	1546..1665	CDD:176041	100/118 (85%)
unc13a	XP_068072457.2	None