DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment UNC13A and unc-13

DIOPT Version :9

Sequence 1:NP_001073890.2 Gene:UNC13A / 23025 HGNCID:23150 Length:1703 Species:Homo sapiens
Sequence 2:NP_001245427.1 Gene:unc-13 / 43841 FlyBaseID:FBgn0025726 Length:3186 Species:Drosophila melanogaster


Alignment Length:1939 Identity:965/1939 - (49%)
Similarity:1236/1939 - (63%) Gaps:322/1939 - (16%)


- Green bases have known domain annotations that are detailed below.


Human     7 GVKK----AKFDGAQEKFNTY-----VTLKVQNVKSTTIAV-----RGSQPS------------- 44
            |:||    :|..|..:|..||     |..:..|:..:.:.:     .|:..|             
  Fly  1310 GLKKKTISSKMSGLMQKAKTYKRHSFVLRRGCNMSDSELEMPDFVSSGNDNSSISTREILLNQSI 1374

Human    45 ----WEQDFMFEINRLD----LGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGP--GEWLTL 99
                .::||.:: ||.|    ||.::|..|..|                  :|...|  |:...:
  Fly  1375 EVEDEQEDFNYK-NRCDSKSVLGGSIEKLNGNL------------------TNNLFPIVGDLKKI 1420

Human   100 DSQVIMAD-SEICGTKDPTFHRILLDTRFELPLDIPE---EEARYWAKKLEQLNAMRDQDEY--- 157
            .|.:.:|. :||...||...::  .|:....|:::|:   |.|..     ::||.....|:.   
  Fly  1421 QSPLPLAVLTEIPSYKDEYSNK--SDSIKNSPIEMPKILLETACN-----QELNLAHSDDDVDKN 1478

Human   158 -------------SFQ-----DEQDKPLPVP-------------------SNQCCNW-NYFGWGE 184
                         :|.     ::..:|...|                   :.||.:. ||.|||.
  Fly  1479 ILANSAKDYVNAPTFSILKTVEDASEPTMTPLHTTTTTNSSLNVTSALWVTQQCLDLPNYPGWGS 1543

Human   185 QHNDDPDSAVDDR--DSDYRSETSNSIPPP----YY----TTSQPNASVHQYSVRPPPLGSRESY 239
            :.:||..|....|  .|..|..|.:||...    ||    ...|.....|..::   |...|::.
  Fly  1544 REDDDNRSQHSARTLSSSRRQSTEDSIDTDDEYFYYELRQLEEQEKQRAHNSAI---PSCERQND 1605

Human   240 SDSMHS--------------------------------------------YEEFSEPQALSP--- 257
            :|.:.|                                            ::|.....:|:|   
  Fly  1606 NDVLFSQIGQLLQNDVNGGDGFRHSNGCNDGEDAIIFSPSESVKLRMSEVFKELKSVVSLNPSVN 1670

Human   258 -------------------TGSSRYAS----SGELSQGSSQLSEDFDPDEHSLQGSDME------ 293
                               |.|..:::    :|:|...:|    |.|.:|..:.....|      
  Fly  1671 NDATFEGVPIVKPTYEKLETVSDLHSAWQDVNGDLQIAAS----DIDSNEDLVGNKGRETPTYNK 1731

Human   294 ---------DERDR---------DSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPED 340
                     ..|||         .|..||||              |.|....|....::....:|
  Fly  1732 QRKLRRLKKKTRDRKINISKNATSSSSSCHS--------------ENECNTPLGQCTQKSVAEKD 1782

Human   341 EEELEEEEEEVPDDLG--SYAQREDVAVAEPKDFKRISLPPAAPGKE------------------ 385
            ..::..:.|...:..|  :.|:..||.::|.::..|     |..|:.                  
  Fly  1783 TNDISNKSEASSETSGPDTPAELSDVDISETENGLR-----ADDGQNIDNMRGNSGSLLKVNRKY 1842

Human   386 ------DKAPV-APTEAPDMAKVAPKPATPDKVPAAEQIPEAEPPKDEESFRPREDEEGQEGQDS 443
                  |.:.: .|.|.........:..|...:|:..:..:::....:.|........|.|....
  Fly  1843 LLQFDVDHSLINQPLETSQYNTHMLENITSASIPSQNRQIDSKTLMSQSSHADGSQAVGNETAVG 1907

Human   444 MSRAKANWLRAFNKVRMQLQEARGEGEMSKSLWFK------GGPGG-GLII------------ID 489
            :|.:|...|:...:  .:::|...:.::.:....|      ||||. ||..            ||
  Fly  1908 LSSSKWKLLKTLKE--RKIEEKNNQDKIKEDEMIKDRDKNGGGPGEVGLRTNGHPGDNPFYSNID 1970

Human   490 SMPDIR-KRKPIPLVSDLAMSLVQS--RKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCT 551
            |||||| :||.|||||:|.:..:.:  |.||:|||:..:|||:|:||.|||||.|||||||||.|
  Fly  1971 SMPDIRPRRKSIPLVSELVLKTMAATKRNAGLTSAVPRATLNDEDLKMHVYKKALQALIYPISST 2035

Human   552 TPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGA 616
            |||||.:||||:||||||||||||||||||:|||||||||||||:||||||||||||||||||||
  Fly  2036 TPHNFLLWTATSPTYCYECEGLLWGIARQGVRCTECGVKCHEKCKDLLNADCLQRAAEKSSKHGA 2100

Human   617 EDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISIT 681
            ||:..:||..:|||||.|||.||||||||:.:|:|.:.:|...|||||||||||||||||||:||
  Fly  2101 EDKANSIITAMKDRMKQREREKPEIFELIRAVFSVEEKSHAGHMKAVKQSVLDGTSKWSAKIAIT 2165

Human   682 VVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDED 746
            |:|||||.||||:|:|||||||||.|.||||:|:...|||||.|.||||||||||||||||||||
  Fly  2166 VICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNPVWNEKFHFECHNSSDRIKVRVWDED 2230

Human   747 DDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEK 811
            :|:||:::|:..|||||||||||||||||||||||||||:|||||||||||||||||||||||||
  Fly  2231 NDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEK 2295

Human   812 VAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQ 876
            |||||||||||||||||::.: :|.|:||:|..|||||||:|:||..:||||||:||||:|:|||
  Fly  2296 VAPYHVQYTCLHENLFHYLCE-ENTGMVKLPTQKGDDAWKLYFDEIPEEIVDEFSMRYGIENIYQ 2359

Human   877 AMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLH 941
            |||||.|||:||:|||||||||||||||||||||||||:.|||||||||||||||:|||||||||
  Fly  2360 AMTHFHCLSAKYLCPGVPAVMSTLLANINAYYAHTTASSAVSASDRFAASNFGKEKFVKLLDQLH 2424

Human   942 NSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNS 1006
            ||||||||||||||||||||:|.||||||||||||||||||||||.||||||.||||||||||.|
  Fly  2425 NSLRIDLSMYRNNFPASSPEKLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVKDCVKACLRS 2489

Human  1007 TYEYIFNNCHELYSREYQTDP--AKKGEVLPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPC 1069
            ||:::|.||:|||:||:|.||  ||:.   |::..|.:.::|||.|||.||||:|:||||||...
  Fly  2490 TYQFLFENCYELYNREFQVDPNEAKRA---PDDHEPKLDSVDFWHKLIALIVSVIDEDKNSYGTV 2551

Human  1070 LNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAF 1134
            |||||||||:|::||..||:|||.|||||:|||::||||||:.||||||:|||||:.||.|:|.:
  Fly  2552 LNQFPQELNIGQLSASSMWHLFAVDMKYALEEHEQHRLCKSSAYMNLHFRVKWLYSNYVKEVPPY 2616

Human  1135 KDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQS 1199
            |..||:|||||||||:|||:||::||.::||||.:||||||||::|||||||.||||||:||.|.
  Fly  2617 KGAVPDYPAWFEPFVMQWLNENDDVSLEYLHGAFKRDKKDGFQKSSEHALFSNSVVDVFTQLTQC 2681

Human  1200 FEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRV 1264
            |:::.|||||||:|...|||||||||..||:.||||:..:|..:  .:.|::.||||||.|||||
  Fly  2682 FDVVSKLECPDPEIWKRYMRRFAKTIVKVLIAYADIVKLEFPEH--MKDERIACILMNNIQQLRV 2744

Human  1265 QLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKG- 1328
            |||||||:|||.:|:.:|::||||||..||:.||:|:..||.|.:|.|.:.|:::||:|..:|| 
  Fly  2745 QLEKMFESMGGDKLEEDAANILKELQQNLNSALDDLASQFAISLEPRITQSVRELGDMLLSIKGG 2809

Human  1329 -----TGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEK 1388
                 .||:.|.. ::||.:||.||:|:|||||.:|||:|:.||||||||:||||||:||..:||
  Fly  2810 SGTLAAGNLAAQR-NAVAVEADEVLRPLMDLLDGSLTLYAQSCEKTVLKRLLKELWKIVMRILEK 2873

Human  1389 TIVLPPLTDQTMIGNLLRKHGKGL-------EKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHM 1446
            ||||||:||:||:...|..:.|.|       :.||: ..||..|.|.:.:|...:..:||     
  Fly  2874 TIVLPPMTDKTMMFKHLTDNAKNLASNAKIEDMGRL-FKSHMAGKQDVKSALSGVMDISK----- 2932

Human  1447 VREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKT 1511
              |..|:|:||||||:::|||||||||||||.|||||||||||:|||||||||||||.||.||||
  Fly  2933 --EVEKNLSPKQCAVLDVALDTIKQYFHAGGNGLKKTFLEKSPELQSLRYALSLYTQMTDTLIKT 2995

Human  1512 FVQTQ--SAQGLGVEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQ-TSGIFRPFIEVNI 1573
            |:.:|  .......|:.|||:||.::||:|||||||||.|||||||||||| .||:||||:::|:
  Fly  2996 FISSQVHEVDLENSEESVGEISVQIDLFSHPGTGEHKVNVKVVAANDLKWQIPSGMFRPFVDINL 3060

Human  1574 IGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVL 1638
            |||.|.:||||||||||:|:|:|||||||.||:..:...:.:||.:|||||||||:||.||:||:
  Fly  3061 IGPHLQEKKRKFATKSKSNNWSPKYNESFSFTIGNEEQLDFFELHICVKDYCFARDDRLVGVAVI 3125

Human  1639 QLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTR 1692
            .|::::::||.||||||.|||.||:||.|:|||||||:|||||||||||||:.|
  Fly  3126 PLKDISEKGSVACWLPLMRRIEMDETGWTILRILSQRNNDEVAKEFVKLKSEIR 3179

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UNC13ANP_001073890.2 C2A_Munc13 1..127 CDD:176040 32/157 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..445 58/389 (15%)
C1 554..603 CDD:237996 43/48 (90%)
C2B_Munc13 676..802 CDD:175993 102/125 (82%)
DUF1041 994..1102 CDD:283860 68/109 (62%)
Membr_traf_MHD 1347..1508 CDD:287505 100/167 (60%)
C2C_Munc13 1546..1665 CDD:176041 77/119 (65%)
unc-13NP_001245427.1 C1 2038..2087 CDD:237996 43/48 (90%)
C2B_Munc13 2160..2286 CDD:175993 102/125 (82%)
DUF1041 2477..2584 CDD:283860 68/109 (62%)
Membr_traf_MHD 2832..2992 CDD:287505 100/167 (60%)
C2C_Munc13 3032..3152 CDD:176041 77/119 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 369 1.000 Domainoid score I912
eggNOG 1 0.900 - - E1_KOG1011
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H11279
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001626
OrthoInspector 1 1.000 - - otm41575
orthoMCL 1 0.900 - - OOG6_103034
Panther 1 1.100 - - O PTHR10480
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R10279
SonicParanoid 1 1.000 - - X1191
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.800

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