Protein Alignment UNC13A and ync13

DIOPT Version :10

• Sequence 1: NP_001073890.2
• Gene: UNC13A / 23025
• HGNCID: 23150
• Length: 1703
• Species: Homo sapiens
• Sequence 2: NP_594926.1
• Gene: ync13 / 2542968
• PomBaseID: SPAC11E3.02C
• Length: 1237
• Species: Schizosaccharomyces pombe
• Alignment Length: 1259
• Identity: 240/1259 - (19%)
• Similarity: 433/1259 - (34%)
• Gaps: 378/1259 - (30%)

Human   496 KRKPIPLVSDLAMSLVQSRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWT 560
            :|||:||.|:              ...|:.:::.:||.:...|..|...:.....:||...:..:
pombe     4 RRKPLPLHSN--------------EVQAAESISKDELYSWTLKNVLILFLVQYRASTPSALQTSS 54

Human   561 ATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIM 625
            .:||.                          .:|.....:........:|.:....:|..:.:.:
pombe    55 FSTPV--------------------------EKKTNGAFSGSLFSAKEKKDNPKYPKDFIKYLSL 93

Human   626 VLKDRMKIRERNKPEI-FELIQEIFA-----VTKTAHTQQMK---AVKQSVLDGTSKWSAKISIT 681
            .|:   .|....:||. .:||:..||     :.|:..::|:|   .::...|...|..|::::..
pombe    94 ALE---SISMGKEPEYQDQLIRGCFAAFYNNINKSHISKQLKDSRKIEDMFLIFASSVSSELTKR 155

Human   682 VVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNL-NPVWEENFHFECHNSSDRIKVRVWDE 745
            :..|......|:       :|....:..||. |:.|.| :|..|...|.:.::|      ::.::
pombe   156 LGTAYDSNLADR-------ITASFIELCKRV-TLKGQLASPSSEFVSHLDMYHS------KLLNK 206

Human   746 DDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEE 810
            .:.:.::   |..|..|.|...:...::..|....|.|:       .|:..|.:|..|::   |.
pombe   207 SEILSTK---RVNRGQDQFDLSSFPLLKVFSSVFKVAYS-------KALLDAEKLFPSID---EA 258

Human   811 KVAPYHVQYTCLHENLFHFVTDVQ------NNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRY 869
            .:|          |::...:.|::      ::.||...:.|....||      |:|:       .
pombe   259 AIA----------EDIGILIEDLESDACKFSHSVVDFSNYKSYSTWK------AREL-------Q 300

Human   870 GVESIYQAMTHFACLSSKYMCP----GVPAVMST--------------LLA-------------- 902
            .:|...:.|.....|||....|    |.||...|              ||:
pombe   301 TLEQHRKIMLSLIPLSSSPNHPIQPIGFPASRKTPTYVPPIARPYFRQLLSLCLEYRLQVTDPVE 365

Human   903 --NINAYYAHTTASTNVSASDRFAAS-NFGKERFVKLL----------DQLHNSL---------R 945
              .||.:....:....:..|.|.|.| :|.:|...|.|          .:||.||         :
pombe   366 VKQINTFIRECSIYWRILPSTRCALSMDFAREHLQKGLITSADVLTHFGELHKSLKEWEITYWPK 430

Human   946 IDLSMYRNNFPASSPERLQDL-KSTVDLLTSITFFRMKVQELQSPPRASQVVKDCV--------- 1000
            ||:|::.:..........|.| ||.:|||      ..|..:..   |...::..||
pombe   431 IDVSIFSSALFGIRNALAQLLKKSLLDLL------HEKKADFH---RWLNIMSICVEDGKVINQD 486

Human  1001 ---KACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLITLIVSIIEED 1062
               |:.::|....:..:|..::..|:..........|.|        :...|..|::.:..:|.:
pombe   487 LSPKSEISSVALALQEHCKVIFDEEFDLSKLPSSNFLDE--------IILASNRISVRIKFLERN 543

Human  1063 KNSYTPCLNQFPQ-ELNVGKISAEVMWNLFAQDMKYAME------EHDKHRLCKSADYMNLHFKV 1120
            .:.....:...|| .:|:      |:.|.....:..|.|      ..|.:.|.|  |.:.::..:
pombe   544 CSECIYGVLSLPQIFINI------VLPNYIRAALVVAKEYLREKANADINDLTK--DMLEIYSDL 600

Human  1121 KWLYN---EYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEH 1182
            |.:.:   ||..|    :.|:..:..:|:||:..|||..|..:..:...:||   ||.|.:.|..
pombe   601 KQMIHVLQEYHNE----EYRIGSFEGFFQPFIDSWLDNVEASAEQWFLRSLE---KDNFDENSSE 658

Human  1183 ALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDF------- 1240
            ..:|.|:||:|...:|:|..::..|..|......:..||.:.|..||.:|....::.|
pombe   659 GQYSSSIVDLFHAFHQAFRTLEGFEWEDDLANARFFTRFFRVIYIVLSKYTQWTTQKFFEEANKQ 723

Human  1241 -----------ASYCSKEK-------EKVP-------CILMNNTQ---------QLRVQLEKMFE 1271
                       :|:.||.:       |.:|       |||:||..         :.::.|:::.|
pombe   724 DDTSEVQNDNSSSWFSKARNILSGSNEVLPFRFSPTMCILLNNIHFAMHAYEELEQKIDLQRLIE 788

Human  1272 AMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKG--TGNV-P 1333
            |:       :.::..|..::...|.|..:..|......|.....::....:|:..||  .|.. |
pombe   789 AL-------DVAESTKRHKISATNYLYTIKVVRGEGLHPDGAGKIRTSYIVLTDNKGRRIGKTRP 846

Human  1334 ASACSSVAQDADNVLQPIMDLLDSNL-----------------TLFAKICEKTV----------- 1370
            ..:.:....|...|......::.:||                 ||..||....:
pombe   847 IHSMNPRWDDTFEVKTKDALMITANLWSKGKFNDHEIFGRSSFTLSPKIYGDYLPREEWFDLNPH 911

Human  1371 --------------------------LKRVLKELWKLVMNTME-------KTIVLPPL------- 1395
                                      |:|..:|:.|.::|.||       .|..|..|
pombe   912 GELLLRIEMEGEREHIGFYVGRTYHDLERAQREMIKFIVNKMEPVINQNLSTATLKKLLSANTWM 976

Human  1396 -TDQTM--IGNLLRKHGKGLEKGRVKLPSHSDGTQMIFNA----------------AKELGQ--- 1438
             .|:||  :.:||.:.|.. .|....:....:.|.:...|                ||.|.:
pombe   977 DLDKTMTSVTSLLNRTGFS-SKSSENVKKEGELTDVQIEAAIYELLDYFDLNFSIIAKHLTKDVF 1040

Human  1439 ---LSKLKDHMV--REE------------AKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLE 1486
               :|.:.|.:|  .||            .|.|:|.|.|:|...|..:|.||:|.|.|:|...||
pombe  1041 VTVMSYVWDEVVCTTEELLLPPVSVKPINRKPLSPAQMAIVYRWLQFLKDYFYANGEGVKLPVLE 1105

Human  1487 KSPDLQSLRYALSLYTQATDLLIK 1510
            .....:.|| ....|.:.||.|::
pombe  1106 TDHYKELLR-VQEYYDKPTDFLLQ 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UNC13A	NP_001073890.2	C2A_Munc13	1..127	CDD:176040
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..445
		C1_Munc13-2-like	535..616	CDD:410409	8/80 (10%)
		C2B_Munc13	676..802	CDD:175993	22/126 (17%)
		MUN	994..1512	CDD:461870	136/690 (20%)
		C2C_Munc13	1546..1665	CDD:176041
ync13	NP_594926.1	MUN	<624..>768	CDD:461870	39/146 (27%)
		C2_Munc13_fungal	806..926	CDD:176008	16/119 (13%)
		MUN	<938..1100	CDD:461870	40/162 (25%)