DRSC/TRiP Functional Genomics Resources

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Protein Alignment UNC13A and unc-13

DIOPT Version :10

Sequence 1:NP_001073890.2 Gene:UNC13A / 23025 HGNCID:23150 Length:1703 Species:Homo sapiens
Sequence 2:NP_001021873.1 Gene:unc-13 / 172497 WormBaseID:WBGene00006752 Length:2155 Species:Caenorhabditis elegans


Alignment Length:2205 Identity:897/2205 - (40%)
Similarity:1201/2205 - (54%) Gaps:591/2205 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVW 65
            |.|||:.:|||:..||.::||:|||:|:|.|||||:||||:.|.|||:|:||.||.|.|:.:|:|
 Worm    18 MRLLCITIKKARLQGAVDEFNSYVTVKLQTVKSTTVAVRGNLPCWEQEFIFETNRPDDGMVLELW 82

Human    66 NKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQVIMADSEICGTKDPTFHRILLDTRFELP 130
            .||::||.::|..::||..||.||..|.|:||.:|.::...:.:..||:.||.|.:|.|.|||||
 Worm    83 AKGVLWDKLIGVHYMPLSEIRYSNAAGSGQWLQMDHELETRNGQTVGTRGPTGHNLLTDVRFELP 147

Human   131 LDIP--EEEARYWAKKLEQLNAMRDQDEYSFQDEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSA 193
            .|:.  :|:.:   .:|..||.:.:.|:....:....|          :|:.|..|         
 Worm   148 FDVQGHDEDIQ---SRLLALNGLIEHDQLGPNNHHRAP----------FNHSGLSE--------- 190

Human   194 VDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPP------LGSRE---SYSDSMHSYEEF 249
                ||||.|:.  |:|..::.. .||:|.|||.....|      |.:||   ||.|...:|...
 Worm   191 ----DSDYTSDV--SVPVNHHQL-HPNSSAHQYESHLHPHRTRQLLHTREGAASYEDEEDAYHAR 248

Human   250 SEPQA-------------------LSPTGSSR--------------------------------- 262
            .:|::                   .:|:|||.                                 
 Worm   249 HQPESDDYNHQDTYDQHSSYYNDEYAPSGSSSQYQRQGYQDQDQQHQNIYEDTVTPVREFGESAV 313

Human   263 ----------------YASSGE------LSQG--------------------------------- 272
                            ||||.|      :|.|                                 
 Worm   314 PPAASSSRRQFDQVYGYASSSEERYDTPMSSGRLPRDEPILEHSEPEYVYDQNGYPEEDNYGINP 378

Human   273 ----------------SSQLSEDF------------------------DPDEHSLQGSD------ 291
                            :.|...||                        .|:.|...|::      
 Worm   379 TYSEDHFEGQTNDYSTTHQEPNDFRNDYNSSYQREYWNESEPLSYNSRPPNGHIRTGANTWREPS 443

Human   292 ------------------MEDERDR--------------------------------------DS 300
                              ..||.||                                      ||
 Worm   444 TSSRPTSSQAWNYQDDTHQYDEVDRGSRVSFTRTPSVDRTDRPSESGGGFYDEMSESGRPGRPDS 508

Human   301 YHSCHSSVSYHKDSPR--WDQDEEELEEDLEDFLEEEELPED------EEELEEEEEEVPDDLGS 357
            :|:........:|:.:  |.|..|..||..|:..::.:.|.|      ::.....:.....|.|:
 Worm   509 HHNWRYDSIQEEDNEKDNWKQHVEGYEEGQEEKQKDNQKPNDHSAASPQDHYHRSDSTAQQDFGN 573

Human   358 YAQREDVAVAEPK---------DFKRI------------------------------SLPPAAPG 383
            ...|:.:...|.|         .:||:                              .|.||..|
 Worm   574 NIVRQTIQEEEEKRNYQELWHNAYKRVCADLGIKSSQASLVATTGGTLLQNLFLYRPKLAPAGHG 638

Human   384 ---KEDKAP----------------VAPTEAPDMAKVAPKPATPDKVPAAEQIP----------- 418
               .:.::|                |:..|.....:..|.|:......:...:|           
 Worm   639 ATASQFQSPAGATRFYANHNNNNNNVSKNELDSTTETPPDPSRTPSTSSMNPVPSLAVPMSPGPY 703

Human   419 -EAEPP--------------KDEESFR------------------------PREDEEGQEG---- 440
             .::||              :.:||:.                        |.|.|||..|    
 Worm   704 LNSDPPSPVSPNPQIKRSIYRIKESYEDRNGGRERIYTTNLVSVYLEKMKPPDELEEGSSGSMRE 768

Human   441 ---------------------QDSM---------------------SRAKAN------------- 450
                                 |||:                     |.|..|             
 Worm   769 TQNEIKNGTQLHNAESNIFFPQDSVPKSISYNAGNLKNTSITTSKTSSAITNHSSLPPQPPSKPA 833

Human   451 ------------WLRAFNKV--------------RMQLQEAR----------------------- 466
                        :.::|.||              |::::::|                       
 Worm   834 SRDSDPMKQLLTFSKSFKKVRRVRSAMPRRRKRKRVKIKKSRSCPILWKTEKTPHPMKSKSMTCI 898

Human   467 -----------------------------------------------------GEGEMSKSLWFK 478
                                                                 |.|..:.:.::|
 Worm   899 RIPKKTVIAPLRKEIKIVRMKPPAARCESDSKAHKKKNLLDVYKDMGKSTVLDGNGSSAANAFYK 963

Human   479 GGPGGGLIIIDSMPDI---RKRKPIPLVSDLAMSLVQSRK--AGITSALASSTLNNEELKNHVYK 538
            .        ||:.|::   |.:..|||||:|.:..:.:::  ||:.:| |.:|.::.|||.||||
 Worm   964 S--------IDAAPNMNVARTKTSIPLVSELVLKTMATKRAQAGLANA-ARTTFSDTELKTHVYK 1019

Human   539 KTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADC 603
            |||||||||||.||||||...|..|||:||||||||||:||||:|||:|.||.|:||::||:|||
 Worm  1020 KTLQALIYPISATTPHNFATTTFQTPTFCYECEGLLWGLARQGLRCTQCQVKVHDKCRELLSADC 1084

Human   604 LQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVL 668
            ||||||||:|||..||||:::.|::|||||:|:||||:|::|:.:|.|.:....:.:|.||.|:|
 Worm  1085 LQRAAEKSTKHGEADRTQSLVNVIRDRMKIQEQNKPEVFQMIRTVFDVDENIQKETLKTVKASIL 1149

Human   669 DGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHN 733
            :|:|||||||::||:|||||.||||||.||||||.||||||:||:||:..|||||.|.|||||||
 Worm  1150 EGSSKWSAKITLTVLCAQGLIAKDKTGKSDPYVTAQVGKTKRRTRTIHQELNPVWNEKFHFECHN 1214

Human   734 SSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAI 798
            |:|||||||||||:|:||:::|:..||||||||||:||||||||||||||||:||||||||||||
 Worm  1215 STDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTVIEVRTLSGEMDVWYNLEKRTDKSAVSGAI 1279

Human   799 RLHISVEIKGEEKVAPYHVQYTCLHENLF--HFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEI 861
            ||||:||||||||:||||||||||||:||  |.|.:     .||:|..:|:|:|||.:.||.|||
 Worm  1280 RLHINVEIKGEEKLAPYHVQYTCLHEHLFAAHCVDE-----EVKLPKVRGEDSWKVCFQETGQEI 1339

Human   862 VDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAAS 926
            .:|||||||:|||||||||||||.::|||.|||||:||||||||||||||||::.|||.||||||
 Worm  1340 AEEFAMRYGIESIYQAMTHFACLCTRYMCAGVPAVLSTLLANINAYYAHTTATSAVSAPDRFAAS 1404

Human   927 NFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPR 991
            |||||||||||||||||||||||.|||:||:|||.:|||||||||||||||||||||.||.||||
 Worm  1405 NFGKERFVKLLDQLHNSLRIDLSAYRNHFPSSSPAKLQDLKSTVDLLTSITFFRMKVLELASPPR 1469

Human   992 ASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSI-KNLDFWSKLITLI 1055
            ||.||::|.|||:..||:.:|.:|                    .||.|.: .::.||.:.|..|
 Worm  1470 ASTVVRECAKACMQQTYQLMFESC--------------------AEQFPILDTSVQFWYEFIDYI 1514

Human  1056 VSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKV 1120
            :.:||||:.:|||.|||||||||||.:|||.:|:::..|:|.|:|||.:.:.||:.:||||:|||
 Worm  1515 MRVIEEDQKNYTPALNQFPQELNVGNLSAETLWSMYKNDLKMALEEHAQKKRCKTPEYMNLYFKV 1579

Human  1121 KWLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALF 1185
            |..|.:||.:|..:|..:||:||||.|||:.||:||:|.|.|.|..|...||.|.|.|||||..|
 Worm  1580 KGFYFKYVADLSTYKSSIPEFPAWFIPFVMDWLNENDEHSMDILRNAYNVDKADNFPQTSEHTKF 1644

Human  1186 SCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFASYCSKEKEK 1250
            |.||||||:|||.:.:::|:::||:|::....|:||:||::.|||.|||::.|||..:.  ..||
 Worm  1645 SNSVVDVFTQLNAALKLLKQMDCPNPEVAADMMKRFSKTLNKVLLAYADMVQKDFPKFA--HDEK 1707

Human  1251 VPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEEC 1315
            :.||||||.|||||||||::|.|||.|||.....:|..||.|||:|||.||..|.|:.:|||.|.
 Worm  1708 LACILMNNVQQLRVQLEKIYETMGGAELDEHIGQVLTVLQKKLNSVLDRLSAEFVTTLEPHIHEQ 1772

Human  1316 VKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWK 1380
            ..::|.:|.::||    |....:.|..:||.||:|:||||:.:|..:|..|||||||.:||||||
 Worm  1773 TIKLGMLLVKIKG----PQLQKTQVQPEADAVLEPLMDLLEGSLRRYADQCEKTVLKYILKELWK 1833

Human  1381 LVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKD- 1444
            :.:..|||.:|||||:|:.::        |.|...::     .|.|:::....:.:..::.:|| 
 Worm  1834 ITIVNMEKRVVLPPLSDKALL--------KQLPNAKI-----GDVTKLMSTNIQSIKGMNSVKDM 1885

Human  1445 -HMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLL 1508
             .|.||..|||||:||.|::.|||.||..|||.|.||||:|.||||:||||:||||||||.|:.|
 Worm  1886 MDMARESEKSLTPRQCTVLDCALDAIKDSFHASGKGLKKSFFEKSPELQSLKYALSLYTQTTEQL 1950

Human  1509 IKTFVQTQSAQGL-GVEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVN 1572
            ||||:.:|..|.| ..|.|||||||.|:||:||||||.|||||::|||||:||||..|:||:||:
 Worm  1951 IKTFITSQRQQDLPSQEQPVGEVSVQVDLFSHPGTGEQKVTVKILAANDLRWQTSSAFKPFVEVH 2015

Human  1573 IIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAV 1637
            ::||.|||||||::||:|..:||||:||:|.|.|..:..||.|||...||||||||:||.||:.|
 Worm  2016 LVGPHLSDKKRKWSTKTKAGNWAPKFNETFHFFLGNEGEPEHYELMFQVKDYCFARDDRVVGVGV 2080

Human  1638 LQLRELA-QRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEE 1696
            |||..:. |.||.|.|:.||.|:|:|:|||.:|||||||..|||||:||:||::.|...|
 Worm  2081 LQLSSVVDQAGSCAMWVQLGTRLHIDETGLILLRILSQRQTDEVAKDFVRLKTECRYETE 2140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UNC13ANP_001073890.2 C2A_Munc13 1..127 CDD:176040 61/125 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..445 85/638 (13%)
C1_Munc13-2-like 535..616 CDD:410409 63/80 (79%)
C2B_Munc13 676..802 CDD:175993 101/125 (81%)
MUN 994..1512 CDD:461870 247/520 (48%)
C2C_Munc13 1546..1665 CDD:176041 71/119 (60%)
unc-13NP_001021873.1 C2A_Munc13 18..144 CDD:176040 61/125 (49%)
DMP1 <309..>591 CDD:462128 34/281 (12%)
C1 1016..1096 CDD:412127 62/79 (78%)
C2B_Munc13 1157..1283 CDD:175993 101/125 (81%)
MUN 1472..1954 CDD:461870 247/520 (48%)
C2C_Munc13 1989..2109 CDD:176041 71/119 (60%)

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