Protein Alignment PDZRN3 and Traf4

DIOPT Version :10

• Sequence 1: NP_055824.1
• Gene: PDZRN3 / 23024
• HGNCID: 17704
• Length: 1066
• Species: Homo sapiens
• Sequence 2: NP_477416.1
• Gene: Traf4 / 33638
• FlyBaseID: FBgn0026319
• Length: 486
• Species: Drosophila melanogaster
• Alignment Length: 277
• Identity: 64/277 - (23%)
• Similarity: 90/277 - (32%)
• Gaps: 103/277 - (37%)

Human    17 KCALCHKV-----LEDPLTTPCGH--VFCAGCVLPWVVQEGSCPAR-CRGRLS-------AKELN 66
            :|..|...     ||:. ...||.  |:|          |..|..| .|||::       ||.|.
  Fly   163 RCEFCQSEFSGAGLEEH-NGSCGQEPVYC----------EAKCGQRILRGRMTLHKSKDCAKRLR 216

Human    67 HVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMR 131
                          :||:    |.|......||.|..:|..||..|........:.|.::|||:|
  Fly   217 --------------RCAH----CQREFSADTLPLHAAQCPRAPLACPQRCDAGPIPRGELEAHLR 263

Human   132 DACDARPVGRC---QEGC------GLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKALKKE 187
            |.|.:..|. |   :.||      .:...|.|..|..|.....      ||.:|.|...:.||.
  Fly   264 DECQSLAVS-CSFKEAGCRFKGPRQMLEAHLESNAAAHLSLMV------ALSSRQGQQIQMLKS- 320

Human   188 ALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARL------DSLSRCVAAPP-------- 238
                           |.::|.:..|..... |.|::||::      |.|.  :.:||
  Fly   321 ---------------AVSKLSINYTGTLLW-KITDWSAKMAEARGKDGLE--LVSPPFYTSQYGY 367

Human   239 ----------GGKGEET 245
                      .|.||.|
  Fly   368 KLQASMFLNGNGPGENT 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZRN3	NP_055824.1	RING-HC_LNX3	12..58	CDD:438378	11/48 (23%)
		Sina	69..>132	CDD:460824	15/62 (24%)
		PDZ1-PDZRN4-like	246..337	CDD:467199	64/277 (23%)
		PDZ2-PDZRN4-like	420..503	CDD:467200
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..603
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..778
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..863
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	14/53 (26%)
		zf-TRAF	233..292	CDD:280357	16/59 (27%)
		MATH_TRAF4	331..479	CDD:239750	12/57 (21%)