DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNRNP200 and l(3)72Ab

DIOPT Version :9

Sequence 1:	NP_054733.2	Gene:	SNRNP200 / 23020	HGNCID:	30859	Length:	2136	Species:	Homo sapiens
Sequence 2:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster

Alignment Length:	2153	Identity:	1598/2153 - (74%)
Similarity:	1873/2153 - (86%)	Gaps:	30/2153 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTKPQMQE 65
            |||..||.||||||||||||||||..||:|.||||.||||.||||||:||||||:.|||||:..|
  Fly     1 MADAAARQLQYEYKANSNLVLQADVRLIERPRRDEATGEVCSLVGKLDGTRMGDRYQRTKPEKTE 65

Human    66 ERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFIQAALGDQPRD 130
            ||:.||:||||.::|..:|||.|||||||||||||:|:|||:|||:||||||||||.||||||||
  Fly    66 ERKVKRQKRDEAQYDFERMKGATLLSEGIDEMVGIVYRPKTQETRQTYEVLLSFIQEALGDQPRD 130

Human   131 ILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKITDYGGD-----KEIQN 190
            ||||||||:||||||::|:|:||:|:||.|||...|.|:.:||||||||||:|.|     ....|
  Fly   131 ILCGAADEILAVLKNDRLKDRERKKDIDSLLGAVTDERFALLVNLGKKITDFGSDAVNALTAAPN 195

Human   191 MDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKK 255
            .::.||||||:|||||..|||.|.|:|||:|::.:.|  ||:||.:..||.|..:|:.|..::.|
  Fly   196 NEEQIDETYGINVQFEESEEESDNDMYGEIRDDDAQD--EGEEARIDHTLHAENLANEEAANNVK 258

Human   256 KD--LHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFI 318
            |:  |||.||||:||||.||:||.||:|||.||.:||:|||.|:|||:||||||||||::.||||
  Fly   259 KERSLHPLDIDAYWLQRCLSKFYKDAMVSQSKAADVLKILKDAADDRDCENQLVLLLGYDCFDFI 323

Human   319 KVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFLYQLHETEKEDLIREERSRRERVR 383
            |.|:.:|.|:||||:|||||:::|::||..||..:..|:|.|.||...:.||  :||...|...|
  Fly   324 KQLKLNRQMVLYCTMLASAQTDSERQRIREKMRGNSALAKILRQLDTGKSED--QEEGEARGSKR 386

Human   384 QSRMDTDLETMDLDQGGEALA-----PRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYE 443
            ...        |.:.||.|.|     .||:|:||::.|||||||||||||||||||:|:||||||
  Fly   387 GKG--------DAEDGGAAAAGQVAGVRQLLELEEMAFTQGSHFMANKRCQLPDGSYRKQRKGYE 443

Human   444 EVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAG 508
            |||||||||.||.:.|:|.||:|||||.|..||||||||||||:||:|||::|||:|||||||||
  Fly   444 EVHVPALKPVPFDANEELQPVDKLPKYVQPVFEGFKTLNRIQSRLYKAALDSDENMLLCAPTGAG 508

Human   509 KTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDH 573
            ||||||:.|:||||||||.|||||..||||||:|||:||||||||:||:|||.|.:||:||||||
  Fly   509 KTNVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSLVQEMVGNFGRRLACYNLTVSELTGDH 573

Human   574 QLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRN 638
            ||.:|:|:|||:|||||||||||||||||||:..||||:|:||||||||:|||||||||||.|||
  Fly   574 QLTREQIAATQVIVCTPEKWDIITRKGGERTFVSLVRLVIIDEIHLLHDERGPVLEALVARTIRN 638

Human   639 IEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQI 703
            ||.|||:|||:|||||||||:||||||||.|.|||||||||:|||.|||.|:|:|||||:||||:
  Fly   639 IETTQEEVRLVGLSATLPNYQDVATFLRVKPDKGLFYFDNSYRPVSLEQQYIGVTEKKALKRFQV 703

Human   704 MNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQ 768
            ||||||||.|||||:|||||||||||||||||||:||||||:||||.||:|||||.|||||||||
  Fly   704 MNEIVYEKTMEHAGRNQVLVFVHSRKETGKTARAVRDMCLEQDTLGSFLKEGSASMEVLRTEAEQ 768

Human   769 CKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQV 833
            .||.|||:|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
  Fly   769 VKNTELKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVIIKGTQV 833

Human   834 YSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLP 898
            |:||||||.||.|||:||||||||||||||||||||||:|.|||:||||||||||||||.:||||
  Fly   834 YNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNHSELQFYLSLLNQQLPIESQFISKLP 898

Human   899 DMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALM 963
            ||||||||||.||:.:||||||||.||||||||:|||||:|||.:|.||||:|.|.||:||||..
  Fly   899 DMLNAEIVLGTVQHLQDAVNWLGYTYLYIRMLRNPTLYGVSHDAIKADPLLEQHRADLLHTAACC 963

Human   964 LDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNIT 1028
            |:::.|:|||:|||:||||:|||||||||:|::|:.|||||||.|||||||||||||||||::|:
  Fly   964 LERSGLIKYDRKTGHFQVTDLGRIASHYYLTHETMLTYNQLLKQTLSEIELFRVFSLSSEFRHIS 1028

Human  1029 VREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMR 1093
            ||||||||||||:||||||:||||||.|||:||||||:||||||||||||:|||::||||.||||
  Fly  1029 VREEEKLELQKLMERVPIPIKESIEEHSAKVNVLLQAYISQLKLEGFALMSDMVFITQSAARLMR 1093

Human  1094 AIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNH 1158
            |||||||.||||||.||||.||||||:||||||.|||||:|:|:|:.||:|||:||:.|||||..
  Fly  1094 AIFEIVLTRGWAQLADKTLTLCKMIDRRMWQSMTPLRQFKKMPDEIAKKLEKKHFPWGRLYDLEP 1158

Human  1159 NEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWI 1223
            :|:|||||:||:||||||:||.|||||||.|:|||||.||:|||||||||||||||||.||.||:
  Fly  1159 HELGELIRVPKLGKTIHKFVHQFPKLELSTHIQPITRGTLRVELTITPDFQWDEKVHGQSEGFWV 1223

Human  1224 LVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRH 1288
            |:||||||:|||||:||||.||:||||.:.||||||||||||||:|:|||||:..||||||||||
  Fly  1224 LIEDVDSELILHHEFFLLKQKYSQDEHQLKFFVPVFEPLPPQYFLRIVSDRWIGAETQLPVSFRH 1288

Human  1289 LILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTG 1353
            ||||||..||||||||||||:||||...|||.|..:||.||||||||||.|||||:|||||||||
  Fly  1289 LILPEKNMPPTELLDLQPLPISALRQPKFESFYSQRFPQFNPIQTQVFNAVYNSDENVFVGAPTG 1353

Human  1354 SGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKL 1418
            |||...|||||:|:....|:.||||:...||||:.|:.||:.|| ..|:.|||.|||||.|||||
  Fly  1354 SGKMTIAEFAIMRLFTTQSDARCVYLVSEEALADLVFADWHSKF-GSLDIKVVKLTGETGTDLKL 1417

Human  1419 LGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIER 1483
            :.||.::|:|.:|||:||||||||||||.:|||:|||:.|:|||.|||||::||||||||||||:
  Fly  1418 IAKGQLVITTADKWDVLSRRWKQRKNVQLVNLFIVDELQLVGGEEGPVLEIVCSRMRYISSQIEK 1482

Human  1484 PIRIVALSSSLSNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYH 1548
            .|||||||:||::|:|||.||||:..:||||||:|||:||||||||:|::|..||:.:|:||||:
  Fly  1483 QIRIVALSASLTDARDVAQWLGCNPNATFNFHPSVRPIPLELHIQGYNVTHNATRIATMSKPVYN 1547

Human  1549 AITKHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETL 1613
            ||.|:|..|||||||.||||.||||||:||..|:|:|..||.|..|:|:.|:||:::|.||||||
  Fly  1548 AILKYSAHKPVIVFVSSRKQARLTAIDVLTYAASDLQPNRFFHAEEEDIKPFLERMTDKTLKETL 1612

Human  1614 LNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVD 1678
            ..||.|||||||..:.|||||||.|||:||.|.||.|||||:::||||||||||:||||.|:|.|
  Fly  1613 AQGVAYLHEGLSASDHRLVEQLFDSGAVQVAVISRDLCWGMSISAHLVIIMDTQFYNGKNHSYED 1677

Human  1679 YPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTK 1743
            |||.|||||:|.||||.:|.:.:||:|||.|||||||||:.||||:||||||.||||||||:|||
  Fly  1678 YPITDVLQMIGRANRPNEDADAKCVLMCQSSKKDFFKKFINEPLPIESHLDHRMHDHFNAEVVTK 1742

Human  1744 TIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEM 1808
            ||||||||||||||||||||:|||||||||||::|||||||||||||.||||||||||||:||:|
  Fly  1743 TIENKQDAVDYLTWTFLYRRLTQNPNYYNLQGVTHRHLSDHLSELVENTLSDLEQSKCISVEDDM 1807

Human  1809 DVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQ 1873
            |..||||||||||||||||||||||:|||:|||||||:||||:|||||::.:||||:.:||.|:|
  Fly  1808 DTLPLNLGMIAAYYYINYTTIELFSLSLNSKTKVRGLLEIISSAAEYEDVVVRHHEEQVLRTLSQ 1872

Human  1874 KVPHKLNN-----PKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSN 1933
            ::|:||..     |||||||:||||||||||||:||..|||.|||:|||||||||||||||||||
  Fly  1873 RLPNKLTGPNETAPKFNDPHIKTNLLLQAHLSRLQLGPELQGDTEQILSKAIRLIQACVDVLSSN 1937

Human  1934 GWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQ 1998
            ||||||:||||||||||||||||||||||||||:.|.:||||:|.:|:||||||:|||:|..|||
  Fly  1938 GWLSPAVAAMELAQMVTQAMWSKDSYLKQLPHFSPEIVKRCTEKKIETVFDIMELEDEDRTRLLQ 2002

Human  1999 LTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEG 2063
            |:|.|:|||||||||||||||:|||||||.|.||..|.|:||||||:|||||||||.||||||||
  Fly  2003 LSDLQMADVARFCNRYPNIELNYEVVDKDRINSGSTVNVVVQLEREDEVTGPVIAPFFPQKREEG 2067

Human  2064 WWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSVDVKE 2128
            |||||||.|:|||:||||||||||||||||||||:.|.|:||||:|||:|:|||||||||::|.:
  Fly  2068 WWVVIGDPKTNSLLSIKRLTLQQKAKVKLDFVAPSPGKHDYTLYYMSDSYLGCDQEYKFSIEVGD 2132

Human  2129 AETDSDSD 2136
            .:::|:|:
  Fly  2133 FQSESESE 2140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNRNP200	NP_054733.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..80		19/29 (66%)
		Helicase_PWI	254..363	CDD:407980	68/110 (62%)
		BRR2	452..1241	CDD:224125	640/788 (81%)
		DEIH box	615..618		2/2 (100%)
		PRK00254	1310..1897	CDD:234702	421/591 (71%)
		DEXHc_Brr2_2	1325..1515	CDD:350779	129/189 (68%)
		DEVH box	1454..1457		2/2 (100%)
		SEC63	1809..2125	CDD:214744	254/320 (79%)
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	633/774 (82%)
		DEAD	482..661	CDD:278688	143/178 (80%)
		HELICc	773..859	CDD:197757	79/85 (93%)
		Sec63	982..1285	CDD:280962	241/302 (80%)
		DEXDc	1320..1506	CDD:214692	126/186 (68%)
		DEAD	1329..1495	CDD:278688	115/166 (69%)
		HELICc	1615..1694	CDD:197757	58/78 (74%)
		Sec63	1811..2127	CDD:280962	251/315 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143526
Domainoid	1	1.000	519	1.000	Domainoid score	I307
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5859
Inparanoid	1	1.050	3163	1.000	Inparanoid score	I15
Isobase	1	0.950	-	0	Normalized mean entropy	S560
OMA	1	1.010	-	-		QHG54133
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	1	1.000	-	-		FOG0001085
OrthoInspector	1	1.000	-	-		oto89173
orthoMCL	1	0.900	-	-		OOG6_100305
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R148
SonicParanoid	1	1.000	-	-		X2806
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750