Protein Alignment CNOT1 and Not1

DIOPT Version :10

• Sequence 1: NP_057368.3
• Gene: CNOT1 / 23019
• HGNCID: 7877
• Length: 2376
• Species: Homo sapiens
• Sequence 2: NP_001286252.1
• Gene: Not1 / 5740252
• FlyBaseID: FBgn0085436
• Length: 2511
• Species: Drosophila melanogaster
• Alignment Length: 2579
• Identity: 1196/2579 - (46%)
• Similarity: 1594/2579 - (61%)
• Gaps: 297/2579 - (11%)

Human     7 SLALSQISYLVDNLTKKNY-RASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQ 70
            :|.|:...|.:.....|.| ..|..:|...|..||.||||..||.|||.::|| |...|.....|
  Fly    12 ALILASKPYAMQLFDSKPYITDSIYDILQFVKEHGLEADRSSLRHLFSVINFS-DLVPSVTVQLQ 75

Human    71 TQFLIQECALLITKPNFISTLSYAIDN--PLHYQKSLKP--APHLFAQLSKVLKLSKVQEVIFGL 131
            .:.|..:....:...:|:|.:.||.|.  ..:.::||||  ...|..|::::..::||.|.:|.|
  Fly    76 AKLLGIQLERQLHSSSFVSNICYAFDQFFASNQKQSLKPVAVADLVGQVARLTGINKVCECVFAL 140

Human   132 ALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAF 196
            ||.:||.::|:..|...:|..|.:|:.||:....:|..:.|.::|:.::|..||..|       .
  Fly   141 ALTHSSYTELKHSARNNLKGSLSELIDSYLGNKGTGPADSGLREISFDLLQYLLCCL-------S 198

Human   197 GVGQEQIDA-FLKTLRRDFPQERCPVVLAPLLY-------------------------------- 228
            ...|.|::| ||..||.:||::..|:||||.||
  Fly   199 EYVQPQVEAQFLIKLREEFPRQAVPLVLAPFLYGSTTATIAGAGASETDAEAEATTNSNSSSFEA 263

Human   229 --------PEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIVQFGVREV 285
                    .:..|.|.:.|..:.|  ...:|::|..:.:.|:||.|.:|:|||:|.:..   ||.
  Fly   264 DALNEVGIEDIYDHLSEIIFTNQG--KNNIMDTSWINLILEIGYEFTSSVEECKNHLCS---RER 323

Human   286 TAAQ-----VARVLGMMARTHSGLTD---GIPLQSISAPGSG----------------------- 319
            ..|:     ||:::|:|.|.||.|.|   .:|..:...||.|
  Fly   324 ERAELQSKDVAKIVGLMCRRHSSLLDCNVNLPTPANFWPGQGQGGGSNSSGSSQTQITPQQQNPG 388

Human   320 -----------IWSDGKDKSDGAQA-HTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSK 372
                       ..||.|||.:..:| .||..:|.:..|||:.|.||:|:|..|||||.|.::|..
  Fly   389 SSNNNDGSDGNSSSDKKDKKETTEATQTWKPDVFVQALKEVVPQLNWKDVCMELDHPEFVLKDRI 453

Human   373 GLHNVVYGIQRGLGMEVFP-VDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKA 436
            ||..::..::...|..:|| .:.|||.|.:.|||||.|...|.||::|.|||:.....|.|:||.
  Fly   454 GLELLLTILRLATGSNIFPHPECIYRHWANTEGQLSLIATMLKNPDLFSFADFVFSQPALDVLKT 518

Human   437 PPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHE 501
            .|:.||:||::||||.|:|.||.:|:.|.|.||.:||.||.::|||:|.||||..:.....||.:
  Fly   519 APDADNKEISSWKSLHLVEVLLSIADKGYYTQVHELFKFPAQNCPDVLFLALLNTSPPMTPLRQD 583

Human   502 LISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQD 566
            |.:.|:|.||||||||.:||..||  ...:..:|..||:||:|||:||.::||.|||||||:|||
  Fly   584 LFNQLIPTFLGNHPNSNVILASAW--SSNNFQLRSNIMNAMSEWYLRGNEFDQVKLSRILDLAQD 646

Human   567 LKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGL 631
            |||||.|||...|.|:||||.||||||||||:||||||||||||||:||.:..|.||||.::...
  Fly   647 LKALSALLNARSFLFIIDLACLASRREYLKLEKWLTDKIREHGEPFMQAIIKVLHRRCPQVINAK 711

Human   632 APEKDQ--PKSAQLPPETLATMLACLQACAGSVSQ-ELSETILTMVANCSNVMNKAR---QPPPG 690
            .|| ||  ||.|||.|||:.||:.|||.|..:..| |:.|.|:.|.||.:.:.||||   |..||
  Fly   712 VPE-DQLPPKQAQLLPETVTTMINCLQTCINNCMQPEMVEVIMQMTANVAIMANKARAQQQQQPG 775

Human   691 VMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSP----- 750
            ::|   ||         |..|  |.|...:.:.|...|        ||        ||.|
  Fly   776 LVP---PP---------PPTI--LRGHRGMDLPGGIVP--------PP--------PQQPFSGNL 810

Human   751 -AKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPF---------- 804
             |:.|.|...| .|...:.:.||:...|.|....|::. .....|..|..|..|.
  Fly   811 NAQMFGPGMDP-LTNMSNNLAGLNLSGPNGAFNFGNML-TSPSRLMTPGANPYPLNLMQMPQAPP 873

Human   805 ------VQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPT 863
                  :.|.| ..|..|.|...:...|:..:.|..:.....|||::||.||||||||||.|:||
  Fly   874 PPNVGNLGRML-PGGPQQQTPTPTPTAPNPNNPVMADLQIPVSKEVEDEVNSYFQRIYNHQPNPT 937

Human   864 MSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLV-T 927
            :|:||||::|||||:|:.:||:|||.|||||||||||||.|||:|||.|||.||||||::.|| |
  Fly   938 LSIDEVLDILQRFKESSNRREQEVFLCMLRNLFEEYRFFCQYPEKELQITAQLFGGIIDRNLVPT 1002

Human   928 YMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYI 992
            ::||||:||.||:|||||.|||:||||:.|||||:.||..|.:||:|:.||.||..||.||.:|:
  Fly  1003 FVALGLSLRCVLDALRKPDGSKLYYFGVTALDRFRTRLHTYNKYCEHIRSIPHFSDFPPHLIQYV 1067

Human   993 EYGQQSRD-PPVKMQG-SITTPGSIA--------LAQAQAQAQVPAKAPLAGQVSTMVTTSTTTT 1047
            |||...:: ||.|:.| |.|.|.:|:        ...:.....:||..|.:|..|....:..|.
  Fly  1068 EYGMHGQEPPPQKLIGLSNTIPSAISSGPGTEPIYRNSSMLGNMPAATPGSGPKSNAAVSHATR- 1131

Human  1048 VAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMT 1112
             .|::.                 |.||||||||| :|.|::..|||.:|:|.|||||||||.|:.
  Fly  1132 -MKSIA-----------------NATNIDTLLVA-NQEEKVTVPPEPVQDKTAFIFNNLSQLNIP 1177

Human  1113 QKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLL 1177
            ||.:|:||.:.:|:.||::||||:||.|:|.|||:||.||||.|||.|.|:.|..||.|||||||
  Fly  1178 QKCDEIKEIMTKEYWPWLAQYLVLKRASMEFNFHTLYYNFLDALKNGEINRFVTKETLRNIKVLL 1242

Human  1178 TSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKV 1242
            .|||...|||||||||||||||||:||.:|:|||..|||:||||.|||.|||||||:|||||||:
  Fly  1243 RSDKGVINFSDRSLLKNLGHWLGMMTLGRNRPILQLDLDLKSLLAEAYHKGQQELLFVVPFVAKI 1307

Human  1243 LESSIRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKD 1307
            ||||.:|.:||.||||||.||.||||||||.|||||||||||||||.|.|::.:|:....|||.:
  Fly  1308 LESSAKSRIFRSPNPWTMGIMYVLAELHQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDPN 1372

Human  1308 RLKNLDEQLSAPKKDVKQP----------------------------EELPPITTTT-------- 1336
            |...::||:|.||....:|                            :::||..::.
  Fly  1373 RTHRIEEQMSQPKPKQLEPVASAPALPREQQSPAQPPPPPQQQQPPQQQVPPPPSSADVDAQNAA 1437

Human  1337 --------TSTTPA--------TNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQA 1385
                    .::||.        |:::..|..||:|:|||.|:||.:...:...:.|.|..|...|
  Fly  1438 AMMMAAGGANSTPGSVSSPNLPTDSSQVALPPPEPRYSYVDVNVSNFQLIGQQLVLPPNTPFLHA 1502

Human  1386 HPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTA 1450
            :|.:|..|..|:||.:.:.:.|:|||||:||..|.|||:|||||||::|:|||.|||.|:|||.|
  Fly  1503 NPGIKHMVVNAVERTITDWLQPIVDRSIRIACATTEQIIRKDFALDADENRMRTAAHQMVRNLAA 1567

Human  1451 GMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAA-QLAQDNCELACCFIQKTAVEK 1514
            ||||||.::.:..:||.||..:..|.| ...|...|:  |||| |||.:|.||.|.|||||:.||
  Fly  1568 GMAMITGKDEIARAISQNLHKALLSGL-NGMPSMAEI--QAAAMQLASENVELVCAFIQKTSAEK 1629

Human  1515 AGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNV 1579
            |..|:|:||:|:||.||.||:||.|:.|..:||||.||:||.:|:|||.......|||.||||::
  Fly  1630 AAAEIDRRLSTDFETRKIAREEGNRFVDAQILTYQQERLPEAVRIKVGAAPATLYAVYSEFARSI 1694

Human  1580 PGFLPTND------LSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAI--PPTLAMNPQA 1636
            |||...:|      :.:||. |:||  ..:|.|| :.:|.:..:::|..::..  .|||.:  ||
  Fly  1695 PGFQQMSDRDIALFVPKPTD-LSQP--NVFANDD-SMVYGELASKMEAFMNTAIGVPTLQI--QA 1753

Human  1637 QALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADL--LLRYRECHLLVLKALQDGR 1699
            ..:..||..::.:|..||..:|..||.:|||||.:.......::  :..|:..||.:|..|.:
  Fly  1754 SKMHMLLNALIATRRLRDQESAFNLLTRAVEGLTEGLVNMHENMEQMKMYQNIHLRILGLLNN-- 1816

Human  1700 AYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQ 1764
            ::|:|...:.:|:|..:.|:|.:|||||...||.:|.||:.|:|..|...|:||.||:|::|.:.
  Fly  1817 SFGAPNTERAVTKCFFDIREEVRYNVEAARALITSHFVNLNQFDGMLRDCMDNGNNYVAISFGIA 1881

Human  1765 LVKILLVDERSVAHVTEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRS-NYEAMI------- 1821
            |::.|::|:|.:..|::.:...|:|.|.|:..| |...||.:...::.:.| |:.:..
  Fly  1882 LLERLIMDDRVINIVSDNEFMATVELLGRLTQH-RHRYPECIVNAIDTLWSGNFNSSSDYSPFNG 1945

Human  1822 -DRAHGGPNFMMHSGIS--QASEYDDPPGLREKAEYLLREWVNLY--HSAAAGRDSTKAFSAFVG 1881
             ||...|.:..:|||:.  ::.:.||||||:||.|:||::||.||  .:..:.||: :.|.|||.
  Fly  1946 NDRYLSGASHYIHSGMHHVRSCDTDDPPGLQEKTEFLLKDWVALYTQQNQQSTRDA-RNFGAFVQ 2009

Human  1882 QMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALL 1946
            :|:..||||||||||||||..|.:|.::.||..||    |:......:.|.:..:||||.|||:|
  Fly  2010 KMNTYGILKTDDLITRFFRQATHICTDVVYRMFAE----PSLPINQAKNKIFQWIDAFVHLIAML 2070

Human  1947 VKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETI 2011
            |:|||||.|..|||||||||||||:|.|::||::|...|||:.|||.|:||.:||...:.:||::
  Fly  2071 VRHSGEAGNPTTKINLLNKVLGIVLGTLIKDHEMRGVSFQQVGYHRFFMMLFMELCTADVILESL 2135

Human  2012 NFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLA 2076
            ....::||..|:|:|.|:.||||.:|||||||||:|:.|:|...|.|||||:|||||.|||||||
  Fly  2136 MHSIVSAFAYTYHLLNPSVAPGFCFAWLELISHRVFLGRILVQIPGQKGWPLYAQLLQDLFKYLA 2200

Human  2077 PFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMR 2141
            |||||.||.||:|:||||||||||||||||||||||||:||||.|||||:|:||:||||||||||
  Fly  2201 PFLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTIPPNCVQMRNIILSAFPRNMR 2265

Human  2142 LPDPFTPNLKVDMLSEINIAPRILTNF-TGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNE 2205
            |||||||||||||||:.:.||::|::: ..:.|..||||||||||.|:||||||:||.:|||::|
  Fly  2266 LPDPFTPNLKVDMLSDSSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPVTFLSELRGHLQVTSE 2330

Human  2206 PGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAI 2270
            ||.|||:.|:||||:||||||||.|.||...|:.|.|.|||||||||||||||||||||||||||
  Fly  2331 PGTRYNMALMNALVMYVGTQAIALIRNKNFVPNTSNIAHSAHMDIFQNLAVDLDTEGRYLFLNAI 2395

Human  2271 ANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAF 2335
            ||||||||||||||||.:|:||||||:||||||||||||||||||||||||||||||||||||.:
  Fly  2396 ANQLRYPNSHTHYFSCAVLHLFAEANSEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPIY 2460

Human  2336 KFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQ-----VMEGTG 2374
            |||:|:||||||||.|||:|||:.|:.:....|     |::|.|
  Fly  2461 KFWDHDFVHCAPEITKLFESVARSCLAKSNVTQQLNMPVVDGEG 2504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNOT1	NP_057368.3	LXXLL	153..157		1/3 (33%)
		LXXLL	181..185		1/3 (33%)
		LXXLL	223..227		3/3 (100%)
		CNOT1_HEAT	500..656	CDD:465113	97/157 (62%)
		LXXLL	570..574		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	720..768		12/53 (23%)
		Interaction with ZFP36	800..1015		124/233 (53%)
		CDC39	<840..2369	CDD:227434	856/1621 (53%)
		Interaction with CNOT6, CNOT6L, CNOT7 and CNOT8. /evidence=ECO:0000269|PubMed:22977175	1090..1605		288/573 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1315..1352		11/88 (13%)
		LXXLL	1639..1643		0/3 (0%)
		LXXLL	1942..1946		3/3 (100%)
		LXXLL	2096..2100		3/3 (100%)
Not1	NP_001286252.1	CNOT1_HEAT	582..737	CDD:465113	97/157 (62%)
		CDC39	<915..2496	CDD:227434	856/1617 (53%)
		Not1	2122..2478	CDD:427680	265/355 (75%)