Protein Alignment CNOT1 and not1

DIOPT Version :10

• Sequence 1: NP_057368.3
• Gene: CNOT1 / 23019
• HGNCID: 7877
• Length: 2376
• Species: Homo sapiens
• Sequence 2: NP_593323.1
• Gene: not1 / 2542001
• PomBaseID: SPAC20G8.06
• Length: 2100
• Species: Schizosaccharomyces pombe
• Alignment Length: 2486
• Identity: 640/2486 - (25%)
• Similarity: 1035/2486 - (41%)
• Gaps: 561/2486 - (22%)

Human     7 SLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFS--GDGKSSGKDFH 69
            |:..:||.:|:..|.:..|....::|:.::|::.|....|.||.|.....:.  |.||||  |..
pombe    41 SIVKAQILFLLSTLREDQYDTKLEQIRQLINKNAPRVYHHFLRRLIQGNSYRIFGTGKSS--DGL 103

Human    70 QTQFLIQECALLITK-----PNFISTLS---------YAIDNPL-HYQKSLKPAPHLFAQLSKVL 119
            .|..|:.:....:||     ..|...:|         :.|:..| |:|         |:.|.:..
pombe   104 ATYKLLLDELKSLTKSWVMAKRFSDAISGSDSEVFEDFDIEAFLDHFQ---------FSPLERTN 159

Human   120 KLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLL 184
            .|         :.|..|....|...|:..:|.....||....|.    .|:   |.|....|.||
pombe   160 LL---------IGLTTSVKPTLAKKASALLKNTFQSLLNQLSDP----TQQ---QSIDKNDLDLL 208

Human   185 LSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKT 249
                   ::|.|....::|                     ||:...|.|.::::.|.:|..:...
pombe   209 -------REGLFTTDYDRI---------------------PLIKVPKFDAIIEKKLANSRPLTAL 245

Human   250 M--MESSLADFMQEVGYGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQS 312
            .  |::|.|..         .|::|.  |:.::.....|...||.::..:...|
pombe   246 FGPMKASKATL---------KSMKEA--ILKKYPPGTATETDVAYLINSLVAIH----------- 288

Human   313 ISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKG--LH 375
                           ..||    |:..::...:.....:||::.:....|:|.|.|..:..  |.
pombe   289 ---------------DYGA----WDTVLMGKAIVSSFENLNWEAMLSMFDNPKFMITGTPSLVLF 334

Human   376 NVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINP-EIFCFADYPCH-TVATDILKAPP 438
            ..::.....|....|.:|.::..|::...|||.|.|.:::| .:|...::..: .|:.|.||
pombe   335 FTIFTNAYKLRQTNFTLDFLWVLWRNPLPQLSIISHIILSPTSMFDIREFNVNPVVSVDSLK--- 396

Human   439 EDDNREIATW-----KS----LDLIESLLR-LAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINT 493
             |.:.|:..:     ||    ::|::.||| |:||..||....|.....|...::|:|..||:..
pombe   397 -DYSEELVNYAKIYEKSNLNCIELVQILLRLLSEVVTYETSLFLNFLDEKVSAELLLLGTLQLPL 460

Human   494 SWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIR------QLIMHAMAEWYMRGEQY 552
            :|:.::..|.......|..|......:.            :|      |.:...:...:::
pombe   461 AWNPVQESLAFQWCSDFFSNFKEHKFVF------------VRIERTNPQFLFAFLRSLWLK---- 509

Human   553 DQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEP-----F 612
            |.:.::::::...:....|.:.|..|..|.:::||||:.|:.|....||..|:.|..:.     |
pombe   510 DSSSVNQVVEFIIENDFTSHIGNIQPNRFALEIAALAAARKALSFQDWLDKKMLEFEDADGLNVF 574

Human   613 IQACMTFLKRRCPSILGGLAPEKDQ----PKSAQLPPETLATMLACLQACAGSVSQELSETILTM 673
            :...:.||..|.       |.:|::    .:|..|..:|:..:|..|.... |:|:|:||.|..:
pombe   575 LVEVLDFLMSRA-------ALQKNESEQKEESVVLSIDTVNVLLTTLMDNV-SISEEVSEHIKDV 631

Human   674 VANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPP 738
            ...|..|
pombe   632 QILCLQV---------------------------------------------------------- 638

Human   739 NLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDP 803
                           :|.|        ||             ||.                :.|.
pombe   639 ---------------YPRL--------FS-------------LGH----------------DRDS 651

Human   804 FVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDE 868
            .|   :.|:..|.                       ||.:::.|..||||.:|..    .:|:.:
pombe   652 IV---IATNTTNS-----------------------FSPDVESEVESYFQALYER----RISIGK 686

Human   869 VLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGL 933
            ::..||.||.|...|:.::|.|:..:||:||||||.||.:.|.:||.|||.:|:..|::::.||:
pombe   687 IVLTLQNFKKSENPRDLDLFACLQHSLFDEYRFFPDYPLEALALTAVLFGSLIQFELLSFVPLGV 751

Human   934 ALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFM----QFPHHLQEYIEY 994
            |||||.:||..|..|||:.||:.||.:|:.:|..|..||..:..|....    .....::|.|..
pombe   752 ALRYVYQALLMPTDSKMFRFGMQALVQFQEKLPKYINYCNLILGIPSLQLVRPDIYDSIREMIAS 816

Human   995 GQQSRDPPVKMQ--GSITTPGSIALAQAQAQAQVPAKAPLAGQVSTMVTTSTTTTVAKTVTVTRP 1057
            .:.:.....|:.  .::..|.|             .|||....||..|
pombe   817 NENTEVEKDKLDSFSALANPAS-------------PKAPEYTFVSIHV----------------- 851

Human  1058 TGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETV 1122
                      |.:|..|.:.            |..|::.:.|.|..|||||.|..:|::::|:.:
pombe   852 ----------PPLNVPNAEG------------EIEESVCDNILFAINNLSQLNFNEKLKDVKDNL 894

Human  1123 KEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFS 1187
            ...::||.|.|:|.:|||.|.||.|||..||:.||:.:..|:|..:|.:.|..::.::....:.|
pombe   895 TPAYLPWFSHYIVTQRVSREANFLSLYGKFLEELKSSDLYKIVFRDTLQAILDIMNNNAETLSPS 959

Human  1188 DRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVF 1252
            :::.|||||.|||.|||.:||||....:..|.||||....|:.:  .|:|||.||||.:..||:|
pombe   960 EKTNLKNLGSWLGSITLLRNKPITTLQVSFKDLLLEGIDSGRID--RVLPFVCKVLEKASSSVIF 1022

Human  1253 RPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKP-----GNLLKDKDRLKNL 1312
            :|||||.|.|:.:|.||:|..|.:||||||||:|..||.:.::.::|     .:|::..|..|.|
pombe  1023 KPPNPWLMGILKLLVELYQFADFRLNLKFEIELLLNNLNVKMDNIEPSEMYRNHLVQKADLEKEL 1087

Human  1313 DEQ-LSAPKKDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITL 1376
            .|. |:|         |.|..|...|....|.::..|.|
pombe  1088 PEDVLNA---------EFPDGTDVITQYIVAASSQITVT-------------------------- 1117

Human  1377 NPTIPLF-QAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIA 1440
            :....:| :..|.:|...:..|:::|.|::..||.||:.||..|.:.:::||||.:|..||:.:|
pombe  1118 DAVAQVFGKPKPAIKNITQLIIQQSVLEIISAVVRRSVGIAAITTKSLLQKDFAAESNPSRLLLA 1182

Human  1441 AHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQ----LAQDNCE 1501
            |..|.:.|...:||:||||||.|.:..|        .||.:.|..|.:..|.||    |...|..
pombe  1183 ARQMAKTLAGNLAMVTCREPLQMLMINN--------FRTIALQDVENVHAAVAQAIDELVSQNLF 1239

Human  1502 LACCFIQKTAVEKAGPEMD---KRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGG 1563
            :|...|:..|.|.|..|:|   :.:..| .:|.........:.||.........:|..::|. ..
pombe  1240 VASSVIESVASETAIAEIDAEIEHMIVE-RVRHRKTTPNLPFVDPAGAANLHLNLPSVLKLS-SE 1302

Human  1564 VDPKQLAVYEEFAR-NVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIP 1627
            :.|:|..:||.|.| ::...:..|..:...|....   .|.:||           .|..:|:...
pombe  1303 LTPQQFQLYENFDRLSLSTIMSNNSFTSLNGLRTD---SADSTD-----------ALNSNLNNTV 1353

Human  1628 PTLAMNPQAQALRSLLEVV--------VLSRNSRDAIAALGLLQKAVEGLLDATSG-----ADAD 1679
            ...|........|:||.::        .:...|...:.|...|.:.|...|...:.     ||..
pombe  1354 ENEANQTALNYARNLLIIIGQLFQLAAQMPYTSMQEVPADHELHELVNQFLTGVASINHPIADHV 1418

Human  1680 LLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIE--CR-----------------DEYKYNV 1725
            .||..:||..::   |.|.:   ||:. .::...::|  |:                 |..|.|:
pombe  1419 FLLCAQECCRIL---LTDSK---SPFI-LEVFSAILEYICQASTKTAINVSLYWNFSNDLEKLNL 1476

Human  1726 EAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVA-FAMQLVKILLVDERSVAHVTEADLFHTIE 1789
            ..:..|||..::...:.|.|:|:.:.:......|. ||::|::..:..|..:|  ...:..::|.
pombe  1477 PIILSLIRFGILTSGEVDYHVARGVRSEQGSGPVTDFAIELLRTAVGGENPMA--LPGNFVNSIT 1539

Human  1790 TLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASE----YDDPPGLRE 1850
            :|..|:....|...:...||:|.                   |:..:|.|||    .|:...|.:
pombe  1540 SLYEISESFSGETKQAYEQLVET-------------------MNKSVSPASEILSDLDNKQQLND 1585

Human  1851 KAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQA 1915
            :...:...||:|..::|. .|.|||  |||.|:|:||||...:|..:||| |....|.:::...|
pombe  1586 QIIIVFVSWVHLLRNSAT-NDETKA--AFVYQLHKQGILSEPELCIQFFR-CNLEAVLVAFLEAA 1646

Human  1916 EQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHS-GEATNTV-TKINLLNKVLGIVVGVLLQDH 1978
            .           :.|..|.|:||:..|:..:||:: |....|| :|..|..|::.:::||..:.|
pombe  1647 S-----------VNAPDYFNVDAYASLLVNVVKYTEGSTEGTVSSKSVLFRKIIALIIGVFAELH 1700

Human  1979 DVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELIS 2043
            :.......|..:.|:|..:|.||:..:.|||:......:.....|..::|...|.|.:|||.|||
pombe  1701 NSMAEFVHQKTFFRLFSSILSELDDAKDVLESCFVDIYSVILECFLAIQPRSFPAFTFAWLSLIS 1765

Human  2044 HRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPE 2108
            |...:.::|. ....|...:::::|:...|:|.  |::.......::||.|.||::||||||||.
pombe  1766 HSYLLPKVLL-VNNDKINDLFSEILMSFLKFLD--LKDDIDKAQFKLLYNGFLRIILVLLHDFPG 1827

Human  2109 FLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMP 2173
            ||..:.|.....||..|:||||::|||||.::.|||||...|||..|.|:..|| :::|......
pombe  1828 FLATHCYQLIPYIPLECVQLRNMVLSAFPSDLHLPDPFAQGLKVGRLPEVTRAP-LISNSVSASL 1891

Human  2174 PQFKKDLD-----SYLKTRSPVTFLSDLRSNLQVS---NEPGNRYNLQLINALVLYVGTQAIAHI 2230
            .:|...||     |..|.......|.::.|:....   ||..|.:.|.||.
pombe  1892 EKFASALDLEACFSSSKPAEVAKLLLEVYSSQDTPTKLNEWANYFMLCLIR-------------- 1942

Human  2231 HNKGSTPSMST---ITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLF 2292
            |....:|:...   .:.|....|...:....|::.||..|.|||||||||:|||:|.||..||||
pombe  1943 HATRDSPAKQAPQFQSKSPECVIISTMNRSCDSKCRYFLLTAIANQLRYPSSHTYYASCCFLYLF 2007

Human  2293 AEANTE----AIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLF 2353
            ..::..    .|:||:|.|||||:|.||||||||||||.||:||..:.||.|.::....||.:||
pombe  2008 KSSSNNPQELLIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLF 2072

Human  2354 QSVAQCCMGQKQAQQV 2369
            .|:.:..|....|..|
pombe  2073 DSLHEHVMAPSSANNV 2088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNOT1	NP_057368.3	LXXLL	153..157		0/3 (0%)
		LXXLL	181..185		2/3 (67%)
		LXXLL	223..227		1/3 (33%)
		CNOT1_HEAT	500..656	CDD:465113	30/170 (18%)
		LXXLL	570..574		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	720..768		3/47 (6%)
		Interaction with ZFP36	800..1015		66/220 (30%)
		CDC39	<840..2369	CDD:227434	480/1603 (30%)
		Interaction with CNOT6, CNOT6L, CNOT7 and CNOT8. /evidence=ECO:0000269|PubMed:22977175	1090..1605		170/529 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1315..1352		9/37 (24%)
		LXXLL	1639..1643		1/3 (33%)
		LXXLL	1942..1946		1/3 (33%)
		LXXLL	2096..2100		2/3 (67%)
not1	NP_593323.1	CDC39	1..2100	CDD:227434	640/2486 (26%)