Protein Alignment SPEN and MRN1

DIOPT Version :10

• Sequence 1: NP_055816.2
• Gene: SPEN / 23013
• HGNCID: 17575
• Length: 3664
• Species: Homo sapiens
• Sequence 2: NP_015140.1
• Gene: MRN1 / 855917
• SGDID: S000006105
• Length: 612
• Species: Saccharomyces cerevisiae
• Alignment Length: 561
• Identity: 108/561 - (19%)
• Similarity: 197/561 - (35%)
• Gaps: 212/561 - (37%)

Human     5 TRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSV--- 66
            :|.:::||:|.|:..:::::|. |.|.||.|||:|::     :.|||.|:|..:|...|:..
Yeast   200 SRTVYLGNVPPNLSVKELLDHV-RSGVVEDVKIIPEK-----MCAFVSFIDESAALLFHSDAILK 258

Human    67 -NKMGDRDLRTDYNEPGTIPS--AARGLDDTVSIASRSREVSGFRGGGGGPAYGPPPSLHAREGR 128
             ..:||||::..:.:|..|..  |||     :|....:|.|
Yeast   259 RLNIGDRDIKIGWGKPTRIDPIVAAR-----ISTDGATRNV------------------------ 294

Human   129 YERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYAS---RSRS 190
            |..|:....:....:.|.......|.|          :.|..:..:|:.:.. :::||   ..:.
Yeast   295 YIGRMTIEGEESHLSEEQLRVDLEEYG----------EIDCIKIIKEKGIAF-IHFASILNAIKV 348

Human   191 PNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDD----ITREVRGRRPERNYQHSRSRSPHSSQSR 251
            .......:|.|:.:            |..|..|    ||         :..||:
Yeast   349 VTNLPIRNPYYQNK------------RIFYGKDRCAFIT---------KTQQHN----------- 381

Human   252 NQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSS---SSTSSDSSDSSSSSSDDSPARSVQSA 313
              :.|.|..|        .|.......|..:.||::   .|.::.:..:|:...::...|:|
Yeast   382 --AAQFLGVQ--------PGMEHMIEFSDREFISNALLQQSAAAAAIATSAGGPNNLGNRTV--- 433

Human   314 AVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFKKFG-----------KVTS 367
                    .|.||.||       :|::.:     ..:::.||....|...           ...:
Yeast   434 --------YLGSLPKD-------VKIEEI-----CNAVRGGLLQSIKLLNDRYVCFVTFIDPTAA 478

Human   368 VQIHGTSEERYGLVFFRQQEDQEK--------------ALTASKGKLFFGMQIEVTAWIGPETES 418
            .|.:..| ..||   |..|:.:.|              ||..|.|
Yeast   479 AQFYAMS-SLYG---FTVQKKRCKVGWGKHSGPLPNALALAVSNG-------------------- 519

Human   419 ENEFRPLDERIDEFHPKATRTLFIGNL---------EKTTTYHDLRNIFQRFGEIVDIDIKKVNG 474
                             |:|.:::||:         |:..|..:||:|||::||     ::::|.
Yeast   520 -----------------ASRNVYVGNIDFVGDSLRDERVFTESNLRHIFQQYGE-----VEQINF 562

Human   475 VPQ--YAFLQYCDIASVCKAIKKM-DGEYLGNNRLKLGFGK 512
            :|:  ..|:.|.:|::...|:.|: ...|..:  ||:.|||
Yeast   563 LPEKNCCFINYTNISNAILALDKIKSNPYFKD--LKINFGK 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPEN	NP_055816.2	RRM1_SHARP	7..81	CDD:409784	24/77 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	70..89		7/20 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..164		6/60 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..209		4/28 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..330		18/107 (17%)
		RRM2_SHARP	336..409	CDD:409785	15/97 (15%)
		RRM3_SHARP	436..509	CDD:409786	23/84 (27%)
		RRM4_SHARP	510..586	CDD:409787	3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	678..871
		PTZ00121	<776..1630	CDD:173412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	957..1020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1070..1287
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1366..1397
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1497..1524
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1588..2171
		PRK10263	<1657..>2249	CDD:236669
		PHA03307	1989..>2371	CDD:223039
		Interaction with MSX2. /evidence=ECO:0000250	2130..2464
		PHA03247	<2183..2588	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2185..2532
		DUF5585	2564..2954	CDD:465521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2566..2590
		Collagen_mid	<2645..>2723	CDD:435053
		Interaction with RBPSUH. /evidence=ECO:0000250	2709..2870
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2775..2806
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2847..2875
		PHA03247	<2948..3488	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2978..3010
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3022..3047
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3135..3156
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3208..3265
		SID/RD	3417..3664
		SPOC_SHARP	3504..3664	CDD:439206
MRN1	NP_015140.1	RRM1_MRN1	200..273	CDD:240964	25/78 (32%)
		RRM2_MRN1	289..372	CDD:409943	16/129 (12%)
		RRM3_MRN1	430..503	CDD:240965	18/99 (18%)
		RRM_SF	519..606	CDD:473069	27/127 (21%)