Protein Alignment SPEN and NRD1

DIOPT Version :10

• Sequence 1: NP_055816.2
• Gene: SPEN / 23013
• HGNCID: 17575
• Length: 3664
• Species: Homo sapiens
• Sequence 2: NP_014148.1
• Gene: NRD1 / 855470
• SGDID: S000005195
• Length: 575
• Species: Saccharomyces cerevisiae
• Alignment Length: 363
• Identity: 82/363 - (22%)
• Similarity: 135/363 - (37%)
• Gaps: 107/363 - (29%)

Human   235 RNYQHSRSRSP----HSSQSRNQSPQRLASQASRPTRSP--------------SGSGSRSRSSSS 281
            |:..:|.|..|    |:..:..:..|.|.|.|...:...              ||...:|..::.
Yeast    81 RSNSNSSSNKPGTCAHAINTLGEVIQELLSDAIAKSNQDHKEKIRMLLDIWDRSGLFQKSYLNAI 145

Human   282 DSISSSSSTSSDSSDSSSSS-SDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLP-- 343
            .|...:...|:::::::|.. |.|...||          .|:||:|:|..|   ..:.: :||
Yeast   146 RSKCFAMDISNNTANTASQQLSLDPKQRS----------KQILSNLKKSPP---LNLNI-SLPTD 196

Human   344 VRSTDTSLKD-GLFH-------EFKKFGKVTSV------QIHGTSEERYGLVFFRQQEDQEK--- 391
            :.|||.:.:. .||.       .||.....|||      |.|..:|  ||   .|::.::|:
Yeast   197 LTSTDPAKQQAALFQVIAALQKHFKTLPSHTSVGTVAPPQAHTITE--YG---SRRERERERERY 256

Human   392 ----------------ALTASKGKLFFGMQIEVTAWIG-PETE---------------SEN-EFR 423
                            ..|..|.:.....|.:.:  || |.|.               |.| .:|
Yeast   257 NSRRNRSRSPPAPFSQPSTGRKDRYPSVAQDQYS--IGAPNTTFGTNNHHLYPDELNVSNNPHYR 319

Human   424 P----LDERIDEFHPKA-TRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAFLQY 483
            |    .|..:...|.|. :||||||.:.......||.|:.:.|.|:..:.:   |...::||::.
Yeast   320 PKPVSYDSTLPPDHIKVYSRTLFIGGVPLNMKEWDLANVLKPFAEVQSVIL---NNSRKHAFVKV 381

Human   484 C---DIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNC 518
            .   :..:|.:...| ||......|..:|||   |.:|
Yeast   382 YSRHEAENVLQNFNK-DGALPLRTRWGVGFG---PRDC 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPEN	NP_055816.2	RRM1_SHARP	7..81	CDD:409784
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	70..89
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..164
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..209
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..330		24/113 (21%)
		RRM2_SHARP	336..409	CDD:409785	22/107 (21%)
		RRM3_SHARP	436..509	CDD:409786	19/76 (25%)
		RRM4_SHARP	510..586	CDD:409787	4/9 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	678..871
		PTZ00121	<776..1630	CDD:173412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	957..1020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1070..1287
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1366..1397
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1497..1524
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1588..2171
		PRK10263	<1657..>2249	CDD:236669
		PHA03307	1989..>2371	CDD:223039
		Interaction with MSX2. /evidence=ECO:0000250	2130..2464
		PHA03247	<2183..2588	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2185..2532
		DUF5585	2564..2954	CDD:465521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2566..2590
		Collagen_mid	<2645..>2723	CDD:435053
		Interaction with RBPSUH. /evidence=ECO:0000250	2709..2870
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2775..2806
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2847..2875
		PHA03247	<2948..3488	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2978..3010
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3022..3047
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3135..3156
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3208..3265
		SID/RD	3417..3664
		SPOC_SHARP	3504..3664	CDD:439206
NRD1	NP_014148.1	CID_Nrd1_like	8..149	CDD:340781	13/67 (19%)
		RRM_NRD1_SEB1_like	336..412	CDD:409768	22/82 (27%)