DRSC/TRiP Functional Genomics Resources

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Protein Alignment SPEN and NAB6

DIOPT Version :10

Sequence 1:NP_055816.2 Gene:SPEN / 23013 HGNCID:17575 Length:3664 Species:Homo sapiens
Sequence 2:NP_013589.1 Gene:NAB6 / 854922 SGDID:S000004585 Length:1134 Species:Saccharomyces cerevisiae


Alignment Length:1375 Identity:242/1375 - (17%)
Similarity:425/1375 - (30%) Gaps:412/1375 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   685 NDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIE---------RSQSPVHLRRPQSPGAS 740
            |...::.:..|:|||::..........:....|   |::         .||.|.:......|...
Yeast     3 NSNSKKPVANYAYRQQQDYNGMNAMVGNPMMYH---PVDFVNGAGQYGPSQHPAYYTNSPLPNIP 64

Human   741 PSQAERLPSDSERRLYSRSSDRS----GSCSSLSP---PRYEKLDKSRLER------------YT 786
            |:     |.|:   .|..|...|    ||....||   ..|.....|.|:|            |.
Yeast    65 PT-----PFDT---AYGASLFPSHLLMGSPFVSSPNMQSGYNSARSSNLKRKAYSRPVSNHNGYN 121

Human   787 KNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSS------QSSETDQENERE 845
            .|..:::..|                           ..|.| :||:      .|...:..:.|.
Yeast   122 GNSNSNQNNT---------------------------NNGMV-TPSNYYRMGRNSFSRNNNSTRN 158

Human   846 QSPEKPRSCNKLSREKADKEGIAKNRL--ELMPCVVLTRVKEKEGKVIDHTP------------V 896
            .:....:.|:  :|..:.:...|:|.:  :::|.::|.|......||:   |            :
Yeast   159 VTHNNNKGCD--TRNNSGRRTFARNNIFDDILPEMLLQRPFCINYKVL---PTGDDAYRTRSLLI 218

Human   897 EKLKAKLD-----NDTVKSSALDQKLQVSQTEPAKSDLSK-LESVRMKV-----PKEKGLSSHVE 950
            |.:...:|     .:.|||:.|:....:   |..|||.|| :|:..:.:     .|...|:.:..
Yeast   219 ENVDHSIDLHSIVKNFVKSNTLESAYLI---EGGKSDDSKDVETKNLSILISFLTKGDCLNFYNN 280

Human   951 VVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVL 1015
            ::::....|.                 ..|.||...:|...|..        .|..|...::..|
Yeast   281 ILQRLSEFKT-----------------FLKSEALNLKFVCLNYD--------PKCLPTFIESEAL 320

Human  1016 SK--KQPDVSSREVIL---LREGEAERKPVRKEILKRES---------KKIK-LDRLNTVASPKD 1065
            ::  ::.|:::...::   |....|.:...|..|::.:|         ||:: |||........:
Yeast   321 TENAEEADITNGSTMISASLHHNIANKDATRSIIIEFKSPVEKSDLFKKKLQFLDRSKNKRYILE 385

Human  1066 CQELASISVGSGSRPSS--------------------DLQARLG-------ELAGESVENQEVQS 1103
            ..:|.:..|.|...|.:                    .....||       .||...|.:.....
Yeast   386 SIDLVNTDVPSNQFPENYAVLTFLNISMAIEVLDYLKKYSKNLGISKCFYVSLAPLVVSSARSSV 450

Human  1104 KKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDI-DHTQ 1167
            ......|....:|.|.........|...|       ....||......::|....||:.: .|:.
Yeast   451 ANIYEGKTSTHRLSVPSVTAGNNNDSNNN-------GNNNKSNMSGITTLNNNSSIGVSVYGHSN 508

Human  1168 SYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDH 1232
            .....:..|         ::.:|:.......:...|......|:     :..|...|:.::...|
Yeast   509 MSLTSLSSS---------VSLNEEIDMLATKLQGVELDGTYLEI-----NYRDYQTPTIEEHSTH 559

Human  1233 VDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGS--PRLLSVKGSP-----KV 1290
            :.   ..|..:...:|||.|:|.  ....|...|...::.....|:  |:.|....||     ::
Yeast   560 LS---NVKISKTTENSRQFSQDI--PSPLPLNEHMFMNDSNQSNGAIIPQQLIATPSPVSPNLQM 619

Human  1291 DEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSF 1355
            :::|||             ||...|..:.....||:.              |.|..|.|      
Yeast   620 NQRVLP-------------NPITQSLEQNFNVSAKVA--------------SSMGSDIG------ 651

Human  1356 PNSIIKRDSLRKRS----VRDLEPGEVPSDSDEDGEHK------SHSPRASALYESSRLSFLLRD 1410
             |..|...::..||    :.::..|.:........|.|      ..:|.|...|.:|.:..::. 
Yeast   652 -NRTIYIGNINPRSKAEDICNVVRGGILQSIKYIPEKKICFVTFIEAPSAVQFYANSFIDPIVL- 714

Human  1411 REDKLRERDERLSSSL------------ERNKFYS---FA-------------LDKTIT-PDTKA 1446
            ..:.||......|..|            .||.:.|   ||             |.:|:: ||.:.
Yeast   715 HGNMLRVGWGHYSGPLPKLISLAVTIGASRNVYVSLPEFAFKEKFIHDPQYKKLHETLSLPDAEQ 779

Human  1447 LLERAKSLSSSREENW---SFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKM 1508
            |.|...:.....:.|:   |...|    .||.|      :.||...:..  |.|:....:..|::
Yeast   780 LREDFSTYGDIEQINYLSDSHCCW----INFMN------ISSAISLVEE--MNKESTVQNESGEV 832

Human  1509 DDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISG---RIYGKQTSEGAN 1570
            ..|:        ..:|.|..|: ...:......|..::.:     :.|:|   |.|.|......|
Yeast   833 TLKR--------ATEEKFGGRY-KGLLINYGKDRCGNINK-----NLIAGKNSRFYKKVKRPSYN 883

Human  1571 STTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPP 1635
            .....::|               ::::.|.|:|.|..:|..:.|:...:.::..:|...|..|..
Yeast   884 IRLSKLEE---------------KRRQNEIDEKEKAFDKPLNLESLGISLDAHKDNGGGETGTAN 933

Human  1636 SVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQV 1700
            :.|..:      ||...| |...|::|                                      
Yeast   934 NTGHEN------ESELEA-ENENGNET-------------------------------------- 953

Human  1701 DLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNV------DPEPDSTQPL 1759
                |:......|:..:.|:..:| |:..|.|....:.|:|.|.::..|      |||    ..|
Yeast   954 ----GSFGGLGLAVASSDVKRATS-DETDYEDIFNKSSGSSDSSSDVEVIMHSPSDPE----YAL 1009

Human  1760 SKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRS 1824
            .....:|.......:::|....|.|       ||...||......|...||.|......|.||.:
Yeast  1010 KSQTLRSSSQTVINSKRPVKIEDEE-------EAVGMSQLNYRSSLRQAPPRAPSTLSYNHSKNN 1067

Human  1825 KTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGE--------AQKLLELKMEAEKITRTASK 1881
            :||:|         .:....|..:..|.||.:..|..        ||.|.:::............
Yeast  1068 ETPMQ---------DIFTNGETANNRKKKRGSFARHRTIPGSDVMAQYLAQVQHSTFMYAANILG 1123

Human  1882 NSAADLEHPE 1891
            .||.|..||:
Yeast  1124 ASAEDNTHPD 1133

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPENNP_055816.2 RRM1_SHARP 7..81 CDD:409784
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 70..89
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 103..164
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..209
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..330
RRM2_SHARP 336..409 CDD:409785
RRM3_SHARP 436..509 CDD:409786
RRM4_SHARP 510..586 CDD:409787
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 678..871 37/219 (17%)
PTZ00121 <776..1630 CDD:173412 165/991 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..941 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 957..1020 9/64 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1287 37/246 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1366..1397 7/40 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1497..1524 3/26 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1588..2171 62/318 (19%)
PRK10263 <1657..>2249 CDD:236669 48/249 (19%)
PHA03307 1989..>2371 CDD:223039
Interaction with MSX2. /evidence=ECO:0000250 2130..2464
PHA03247 <2183..2588 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2185..2532
DUF5585 2564..2954 CDD:465521
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2566..2590
Collagen_mid <2645..>2723 CDD:435053
Interaction with RBPSUH. /evidence=ECO:0000250 2709..2870
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2775..2806
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2847..2875
PHA03247 <2948..3488 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2978..3010
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3022..3047
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3135..3156
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3208..3265
SID/RD 3417..3664
SPOC_SHARP 3504..3664 CDD:439206
NAB6NP_013589.1 RRM 60..99 CDD:402136 12/46 (26%)
Nab6_mRNP_bdg 200..560 CDD:431363 64/411 (16%)
RRM3_MRN1 652..725 CDD:240965 13/73 (18%)
RRM_SF 741..860 CDD:473069 27/139 (19%)
Blue background indicates that the domain is not in the aligned region.

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