Protein Alignment SPEN and nrd1

DIOPT Version :10

• Sequence 1: NP_055816.2
• Gene: SPEN / 23013
• HGNCID: 17575
• Length: 3664
• Species: Homo sapiens
• Sequence 2: NP_592982.1
• Gene: nrd1 / 2541755
• PomBaseID: SPAC2F7.11
• Length: 529
• Species: Schizosaccharomyces pombe
• Alignment Length: 483
• Identity: 95/483 - (19%)
• Similarity: 164/483 - (33%)
• Gaps: 139/483 - (28%)

Human   169 YYRDPRERTLQHGL-----------------YYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVH 216
            :.:.|...|..|||                 |..||..|||..: ..|.|       |.||:...
pombe    55 FVQSPTSYTSMHGLPFSTTQMAAAPAHPTTGYNVSRVTSPNVAN-FAPGY-------FPLPNNTT 111

Human   217 RDIYR------------DDITREVRGR-------RPERNYQHSRSRSPHSSQS--RNQSPQRLAS 260
            :.:..            |:|...||..       .||:|........|..:.:  ::.:.:||
pombe   112 QPVKTVYVGNLPPNTPIDEILSCVRTGPIESAWILPEKNCAFISFLDPSHATAFFQDAALKRL-- 174

Human   261 QASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSS 325
             ..|.|....|.|..|.|:|                                       |.||:.
pombe   175 -TIRGTEVKVGWGKNSASNS---------------------------------------SVLLAV 199

Human   326 LEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFKKFGKVTSVQIHGTSEERYGLVFFRQQEDQE 390
            .:....|..|   :.|||...|:..:::.|    :.||.:..::|  .:|.....|.|.......
pombe   200 QQSGACRNVF---LGNLPNGITEDEIREDL----EPFGPIDQIKI--VTERNIAFVHFLNIAAAI 255

Human   391 KALTA-------SKGKLFFGMQIEVTAWIGPETESENEF--------------RPLDERIDEFHP 434
            ||:..       ||.::::|..........|...|:.:.              .|:.::.| ...
pombe   256 KAVQELPLNPKWSKRRIYYGRDRCAVGLKQPAYFSKGQVGVVGGYPVMGYPPPSPVLQKPD-LIM 319

Human   435 KATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAFLQYCDIASVCK--AIKKMD 497
            ...||::|||:...||..::.|.. |.|.:.:|...:...:   .|:.:.|..|..:  .:..:.
pombe   320 TGNRTVYIGNIHADTTIEEICNAV-RGGLLHNIRYLQEKHI---CFVTFVDPVSAFRFFEMSNIH 380

Human   498 GEYLGNNRLKLGFGK---SMPTNC-----------VWLDGLSSNVSDQYLTRHFCRYGPVVKVVF 548
            |..:.|.|||:|:||   .:|:|.           :::.....:::.:.|...|..:|.:..|.|
pombe   381 GLVIRNRRLKIGWGKHSGPLPSNIALAVAGGASRNIYIGNADDSLTIERLKEDFEEFGEIEYVNF 445

Human   549 DRLKGMALVLYNEIEYAQAAVKETKGRK 576
            .|.|..|.|.:..:..|..|:...|.:|
pombe   446 FREKNCAFVNFTSLASAINAIDRIKQKK 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPEN	NP_055816.2	RRM1_SHARP	7..81	CDD:409784
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	70..89
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..164
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..209		8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..330		18/113 (16%)
		RRM2_SHARP	336..409	CDD:409785	16/79 (20%)
		RRM3_SHARP	436..509	CDD:409786	19/74 (26%)
		RRM4_SHARP	510..586	CDD:409787	17/81 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	678..871
		PTZ00121	<776..1630	CDD:173412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	957..1020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1070..1287
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1366..1397
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1497..1524
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1588..2171
		PRK10263	<1657..>2249	CDD:236669
		PHA03307	1989..>2371	CDD:223039
		Interaction with MSX2. /evidence=ECO:0000250	2130..2464
		PHA03247	<2183..2588	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2185..2532
		DUF5585	2564..2954	CDD:465521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2566..2590
		Collagen_mid	<2645..>2723	CDD:435053
		Interaction with RBPSUH. /evidence=ECO:0000250	2709..2870
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2775..2806
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2847..2875
		PHA03247	<2948..3488	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2978..3010
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3022..3047
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3135..3156
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3208..3265
		SID/RD	3417..3664
		SPOC_SHARP	3504..3664	CDD:439206
nrd1	NP_592982.1	RRM	37..66	CDD:402136	2/10 (20%)
		RRM1_MRN1	114..187	CDD:240964	13/75 (17%)
		RRM2_MRN1	203..280	CDD:409943	18/85 (21%)
		RRM3_MRN1	322..395	CDD:240965	20/76 (26%)
		RRM4_MRN1	411..489	CDD:409942	13/63 (21%)