DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STK38L and wts

DIOPT Version :9

Sequence 1:	XP_024304657.1	Gene:	STK38L / 23012	HGNCID:	17848	Length:	521	Species:	Homo sapiens
Sequence 2:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	203/484 - (41%)
Similarity:	294/484 - (60%)	Gaps:	55/484 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    25 KLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDD 89
            |..:|....|:|..:.:|..|:.:||..|.:.||.|:.:...|....:||:.::||||.::....
  Fly   654 KFFMEQHIENVIKSYRQRTYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSM 718

Human    90 FESLKVIGRGAFGEVRLVQKKDT-GHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKM 153
            |..||.||.||||||.||.|.|| .|:||||.|||:|:|::.||||::||||||.|||..||||:
  Fly   719 FVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKL 783

Human   154 FYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDN 218
            :||||||.|||.:|:::||||:|:||:|.....||..:|||:|...|:|::|::|||||||||||
  Fly   784 YYSFQDKDNLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDN 848

Human   219 LLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFCKFGCCFSSFPWLRYCREQKVLSLS 283
            :|:|..||:||:|||||||.:..|.:::|:...::...|        |..||..|....
  Fly   849 ILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQD--------SMEPWEEYSENG------ 899

Human   284 PLLNPLCFRCICIFFLWRAFFPRDYNSILLKLAFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIA 348
                                 |:.  ::|         .:|:   .:.::|.||:|.||||:|||
  Fly   900 ---------------------PKP--TVL---------ERRR---MRDHQRVLAHSLVGTPNYIA 929

Human   349 PEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKD 413
            |||..::||.:|||:||:|||:||||:|.|||.:.:|.||.:||:||::||..||:..:|.:|.|
  Fly   930 PEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAELSREATD 994

Human   414 LILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDF-PESDIL 477
            ||.|.|..::.|:|.| |:|:|.|.||:|:|:..:|::.|....|||...||||||.. ||....
  Fly   995 LIRRLCASADKRLGKS-VDEVKSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNFDPVDPEKLRS 1058

Human   478 QPVPNTTEPDYKSKDWV---FLNYTYKRF 503
            .....::..|....|..   |..:|::||
  Fly  1059 NDSTMSSGDDVDQNDRTFHGFFEFTFRRF 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STK38L	XP_024304657.1	STKc_NDR2	87..509	CDD:270776	184/422 (44%)
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	180/410 (44%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	161/350 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216969at33208
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920