DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RAB21 and rab-21

DIOPT Version :9

Sequence 1:	NP_055814.1	Gene:	RAB21 / 23011	HGNCID:	18263	Length:	225	Species:	Homo sapiens
Sequence 2:	NP_495854.1	Gene:	rab-21 / 187932	WormBaseID:	WBGene00004279	Length:	207	Species:	Caenorhabditis elegans

Alignment Length:	207	Identity:	110/207 - (53%)
Similarity:	152/207 - (73%)	Gaps:	9/207 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    16 RAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQER 80
            :::.||:||||||||||:|||||:.||||:.||::|:||||..|.:|:...:.:|.||||||||:
Worm     9 KSFKFKIVLLGEGCVGKSSLVLRFVENKFSCKHLSTIQASFQNKTVNVEDCQADLHIWDTAGQEK 73

Human    81 FHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQ 145
            :|||||||||.|||.:||:||||..||:||||||.|::..|||...:.|||||||||:||.|:.|
Worm    74 YHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLGNTAEILIVGNKIDLEEERQVTRQ 138

Human   146 EAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQPGTARRGVQIIDD 210
            :||:||||.||.:..|||:.|.||.:.|..|..:|||.::       ..|::|.:..|.:::||:
Worm   139 DAEAYAESEGALYMETSAQDNVGISDAFESLTAKMIEHSR-------TRSTEPPSTNRSIRLIDN 196

Human   211 EPQAQTSGGGCC 222
            : :|:.| ..||
Worm   197 D-EAERS-KKCC 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAB21	NP_055814.1	Rab21	20..181	CDD:133323	98/160 (61%)
RAB21	NP_055814.1	Ras	21..182	CDD:278499	98/160 (61%)
rab-21	NP_495854.1	Rab21	13..174	CDD:133323	98/160 (61%)
rab-21	NP_495854.1	Ras	14..175	CDD:278499	98/160 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161472020
Domainoid	1	1.000	202	1.000	Domainoid score	I1923
eggNOG	1	0.900	-	-		E1_KOG0088
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8991
Inparanoid	1	1.050	218	1.000	Inparanoid score	I2634
Isobase	1	0.950	-	0	Normalized mean entropy	S698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1226895at2759
OrthoFinder	1	1.000	-	-		FOG0006095
OrthoInspector	1	1.000	-	-		oto23197
orthoMCL	1	0.900	-	-		OOG6_103363
Panther	1	1.100	-	-	LDO	PTHR24073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3888
SonicParanoid	1	1.000	-	-		X4390
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.780