DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9B and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	385	Identity:	96/385 - (24%)
Similarity:	149/385 - (38%)	Gaps:	66/385 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    10 ASVIGTRGLAAEGAHG----------LREEPEF------VTARAGESVVLRCDVIHPVTGQPPPY 58
            :||..:....:||..|          :.|:|||      :|..||.:|.|.|.|.:  .|.   |
  Fly    22 SSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLACSVKN--LGS---Y 81

Human    59 VVEWFKFGVPIPIFIKFGYYPPHV---DPEYAGRASLHDKAS---LRLEQVRSEDQGWYECKV-- 115
            .|.|..|.....:.:.     .||   :|..:.....|||..   |.:..|:.||:|.|.|::
  Fly    82 KVAWMHFEQSAILTVH-----NHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINT 141

Human   116 LMLDQQYDTFHNGSWVHLTINAPPTFTET-PPQYIEAKEGGSITMTCTAFGNPKPIVTWLK-EGT 178
            :....||      .:|.:.:  ||...:. ....|..:||.::|:.|.|.|:|:|.:.|.: :|.
  Fly   142 VTAKTQY------GFVKVVV--PPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGN 198

Human   179 LLGASGKYQVSD---GSLTVTSVSREDRGAYTCRAYS-IQGEAVHTTHLLVQGPPFIVSPPENIT 239
            .:..:...:|.|   .||.:..:||...|||.|.|.: :.........:.|...|.:..|.:.:.
  Fly   199 KIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVG 263

Human   240 VNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDG--------TLIIFRVKPE 296
            :.|..:..|.|..||.|.:|.   ||..||.....:........|.|        .|.|..|:..
  Fly   264 IPIGFNITLECFIEANPTSLN---YWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSS 325

Human   297 DSGKYTCVPSNSLG-RSPSASAYL----TVQYP--ARVLNMPPVIYVPVGIHGYIRCPVD 349
            |.|.|.||..|..| ...:...|:    |.|.|  ...|.........:.:.|||..|::
  Fly   326 DYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTTLRRTTTTAAEIALDGYINTPLN 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	28/96 (29%)
		Ig	41..115	CDD:143165	22/79 (28%)
		I-set	139..225	CDD:254352	23/91 (25%)
		IGc2	153..210	CDD:197706	20/60 (33%)
		I-set	229..321	CDD:254352	26/104 (25%)
		Ig	235..321	CDD:299845	24/98 (24%)
		IG_like	331..414	CDD:214653	4/19 (21%)
		Ig	<353..414	CDD:299845
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	28/111 (25%)
		Ig	69..139	CDD:143165	22/79 (28%)
		IG_like	165..249	CDD:214653	22/83 (27%)
		IGc2	172..237	CDD:197706	21/64 (33%)
		IG_like	267..348	CDD:214653	22/83 (27%)
		Ig	270..339	CDD:299845	21/71 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910