DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9B and DIP-delta

DIOPT Version :9

Sequence 1:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	110/492 - (22%)
Similarity:	170/492 - (34%)	Gaps:	150/492 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    24 HGLREEPEF------VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHV 82
            |.:.:||.|      ||...|....|.|.|.| :.|    |.|.|.                 |:
  Fly    38 HVMMDEPRFAQPIPNVTVAVGRDANLPCVVEH-LGG----YKVAWI-----------------HI 80

Human    83 D---------------PEYAGRASLHDKA-SLRLEQVRSEDQGWYECKV---LMLDQQYDTFHNG 128
            |               |.|:  .:..|.. .|.:.|...:|:|:|.|:|   .|:.|.
  Fly    81 DRQMILTIHRHVISRIPRYS--ITYTDNTWLLHVNQAHQDDRGYYMCQVNTNPMISQV------- 136

Human   129 SWVHLTINAPPTF--TETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKE-GTLLGASGKYQV-- 188
              .:|.:..||..  .|:.|..:..:|..:|.|||.|.|.|.|.:.|.:| |..:....|.:|
  Fly   137 --GYLQVVVPPNILDIESTPSSVAVRENQNINMTCRADGFPAPKIIWRREDGEEIAVEKKKKVLV 199

Human   189 -SDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLL-VQGPPFIVSPPENITVNISQDALLTCR 251
             ....|.:|.|||.:.|||.|.|.:....:|....:| |:..|.|..|.:.:......|..:.|.
  Fly   200 YDADVLPLTKVSRNEMGAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQLVGAPSGTDVTIDCH 264

Human   252 AEAYPGNLTYTWYWQD--------------ENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYT 302
            .||:|..:.| |.:..              ||.| :..:||.:|.|..|          |.|.|.
  Fly   265 TEAHPKAIIY-WVYNSVMVLPSKKYKTDYTENSY-RAHMKLTIRNLQYG----------DFGNYR 317

Human   303 CVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIR---CPVDAEPPATVVKWNKDGR 364
            |:..||||.:                            .|.||   .|:.:.|...|.....:.|
  Fly   318 CISKNSLGET----------------------------EGSIRVYEIPLPSTPSKQVTHTTVESR 354

Human   365 PLQV------------EKNLGWTLMED-----------GSIRIEEATEEALGTYTC---VPYNTL 403
            ...:            :.::|:.:..|           |......::..::.|...   |..|:|
  Fly   355 ENNIIPSSRNDTTKSLQTDVGYAMKNDLYPGSASSSSSGGSSSAASSSSSMQTSALPGGVAGNSL 419

Human   404 GTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLI 440
            .:||  :...|.:....::|..|..||...:...||:
  Fly   420 SSMG--SKGSLAIGKSTFYTERPPNEYAASSVAGLLL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	24/106 (23%)
		Ig	41..115	CDD:143165	19/89 (21%)
		I-set	139..225	CDD:254352	29/92 (32%)
		IGc2	153..210	CDD:197706	23/60 (38%)
		I-set	229..321	CDD:254352	26/105 (25%)
		Ig	235..321	CDD:299845	23/99 (23%)
		IG_like	331..414	CDD:214653	16/111 (14%)
		Ig	<353..414	CDD:299845	11/86 (13%)
		IG_like	426..505	CDD:214653	5/15 (33%)
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	26/124 (21%)
		Ig	145..238	CDD:416386	29/92 (32%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	165..172	CDD:409353	4/6 (67%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	1/3 (33%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	4/6 (67%)
		Ig strand G	230..238	CDD:409353	2/7 (29%)
		Ig	242..333	CDD:416386	28/130 (22%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	2/5 (40%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	4/10 (40%)
		Ig strand F	314..322	CDD:409353	3/7 (43%)
		Ig strand G	325..334	CDD:409353	4/36 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910