DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9B and igsf9bb

DIOPT Version :9

Sequence 1:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens
Sequence 2:	XP_009293693.1	Gene:	igsf9bb / 569554	ZFINID:	ZDB-GENE-091112-15	Length:	1439	Species:	Danio rerio

Alignment Length:	1471	Identity:	1007/1471 - (68%)
Similarity:	1159/1471 - (78%)	Gaps:	66/1471 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKF 65
            |||||||.||||..|||.||:||||:||||:|||:||||:|:|.|||:||:.||  |||||||||
Zfish     1 MIWYVATLIASVFSTRGTAAQGAHGVREEPQFVTSRAGETVILGCDVVHPLNGQ--PYVVEWFKF 63

Human    66 GVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSW 130
            |||||.||.|.:||||||||||||||||.|:|||:|:||||||||||||||||:|||.|||||||
Zfish    64 GVPIPFFINFRFYPPHVDPEYAGRASLHGKSSLRIERVRSEDQGWYECKVLMLEQQYHTFHNGSW 128

Human   131 VHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTV 195
            ||||:|||||||:|||||:|||||||||::|||||||||.|:||:||..:..|.||:|||||||:
Zfish   129 VHLTVNAPPTFTDTPPQYVEAKEGGSITLSCTAFGNPKPSVSWLREGNPVQDSTKYKVSDGSLTL 193

Human   196 TSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLT 260
            .|:||||||||||||||.||||||||.||||||||||||||||||||||||..||:|||||||||
Zfish   194 VSISREDRGAYTCRAYSEQGEAVHTTRLLVQGPPFIVSPPENITVNISQDAFFTCQAEAYPGNLT 258

Human   261 YTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPA 325
            |||:|:::||:|:||||.||.|||||:|||.:|||||:|||||.|||||||.|||||||||.|||
Zfish   259 YTWFWEEDNVFFKNDLKRRVSILIDGSLIISQVKPEDAGKYTCSPSNSLGRPPSASAYLTVHYPA 323

Human   326 RVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEE 390
            ||:||||||||.:|:.|||||||||.||.|.|||.|||.||::||..||:.|||||||:.|.||:
Zfish   324 RVINMPPVIYVAIGLPGYIRCPVDANPPVTSVKWKKDGLPLRIEKYPGWSQMEDGSIRVSEVTED 388

Human   391 ALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWR 455
            :||||||||||:|||||.|.||.|||||||.|.|:||.||||||||||:|||.|.|||||.||||
Zfish   389 SLGTYTCVPYNSLGTMGPSPPAPLVLKDPPKFLVVPGGEYRQEAGRELVIPCEAEGDPFPNITWR 453

Human   456 -KVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQ 519
             ||||||||||:.||.|||||::|||||||||||||:||.|||||||||.|||||||||..|.|.
Zfish   454 KKVGKPSRSKHNVLPRGSLQFKSLSKEDHGEWECVASNVATSITASTHLLVIGTSPHAPAKVHVT 518

Human   520 VSMTTANVSWEPGYDGGYEQTFSVW----MKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQF 580
            ||.|:|||||:..||||:|||||||    :||.|.|||||||:|||.|..||||..|||||||||
Zfish   519 VSTTSANVSWDSSYDGGFEQTFSVWYGHVVKREQLGPHDWLSMPVPSGQHWLLVQGLEPETAYQF 583

Human   581 SVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPID 645
            ||||||||||..||||||||||.|||:|||||||:||||||.||||||||||:|:|||||:.|||
Zfish   584 SVLAQNKLGTGPFSEVVTVNTLVFPISTPEPLVLLTPPRCLTANRTQQGVLLTWIPPANHTSPID 648

Human   646 RYIMEFRVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFP 710
            .|||:||:.|||::|||.||..|.|..|:||.|:.||||||:|||:||:|||||:.||||||.||
Zfish   649 HYIMDFRLGERWDVLDDAIPAGETEILARDLIQEAWYEFRVMAVMEDLVSEPSNVVGVSSTDYFP 713

Human   711 QPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLES 775
            .|::.::||||||:||||||||||||||||||||||||||||:|||||::||||||||||||:|:
Zfish   714 PPEVPDEGLARPVVAGIVATICFLAAAILFSTLAACFVNKQRRRKLKRRRDPPLSITHCRKSVET 778

Human   776 PLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSKKYSVAKAEAE 840
            |.||||:||||||::..|||||:| |..|.|...||.:| ||||||||||||.||||||:|  .|
Zfish   779 PSSSGKISPESIRSIGPPSESSED-GLRAKKFPQSPAKE-ELSLYKKTKRAIISKKYSVSK--HE 839

Human   841 AEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFAEETDMYPEFRQSDEENEDP-LVPTS 904
            ||||||||||||||||||||||.:||..:|:||||||||.||:|:|||||||||||:|| .:|..
Zfish   840 AEATTPIELISRGPDGRFVMDPTDMETPVKARRIEGFPFVEESDLYPEFRQSDEENDDPGPMPPV 904

Human   905 VAALK-SQLTPLSSSQESYLPPPAYSPRFQPRGLEGPGGLE-GRLQATGQAR-PPAPRPFHHGQY 966
            :|.|: .|::|:||||||||.||||||||| |.:||...:| .|||||||.| .|..|.|.|||:
Zfish   905 MATLRPHQISPISSSQESYLQPPAYSPRFQ-RPMEGMTIMETSRLQATGQIRGAPHFRAFTHGQF 968

Human   967 YGYLSSSSPGEVE-PPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGEN------ASNST 1024
            |.||  .||||.| |||||:|:. |||||||||||...||||||||||||.||.      .|..|
Zfish   969 YSYL--GSPGEPEPPPPFYMPDT-SPLSSVMSSPPYHLEGPFGHPTIPEEIGEGEIQHYAVSGYT 1030

Human  1025 LPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFP-------HQLPPCDVPESLQPKAGLPRGLPP 1082
            |||.. |:..|||:.|.||:|.|..:|.|..:||       |..||...|..|.|.|     |.|
Zfish  1031 LPLAH-PSTSRSPDIWQRPDFTFATIEGPHFIFPPPHPLHLHPEPPLPPPLVLPPSA-----LQP 1089

Human  1083 TSLQVPAAYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVL 1147
            ::||| :.|||||.|||||...||||.:......||.:   .|||...|.|||||||.|||:|||
Zfish  1090 STLQV-SPYPGILQLEAPKSRPGKSPSKVKPQGLPAKR---LPMQEAQSLGQLRHTSHGMGVPVL 1150

Human  1148 PYPEPAEPGAH-GGPSTFG-LDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLS 1210
            |||:|.   :| .|||:|| |||||||  ..||.||||.||.|||:  |||||||||||||||:|
Zfish  1151 PYPDPV---SHMVGPSSFGSLDTRWYE--LTPRLSPRQPRRMEPSM--VVLQPSRLSPLTQSPIS 1208

Human  1211 SRTGSPELAARARPRPGLLQ---QAEMSEITLQPPAAVSFSRKSTPSTGSPS--QSSRSGSPSYR 1270
            |..||||:..|.||||.::|   ..||||||||||::.||||:|:||: ||:  |.||..|||||
Zfish  1209 SHEGSPEIVVRPRPRPSMIQPPIPPEMSEITLQPPSSASFSRRSSPSS-SPAQGQGSRRASPSYR 1272

Human  1271 PAMGFTTLATGYPSPPPGPAPAGPGDSLDVFGQTPSPRRTGEELLRPETPPPTLPTSGTLPPAPG 1335
            ..|.|.|.|..|||..|.|    |.:|.::|||.|:.|||.||:|..|..||.|..||....||.
Zfish  1273 SHMAFATSAASYPSQSPSP----PVESSNIFGQMPTQRRTEEEILPSEPSPPQLSASGKRRGAPS 1333

Human  1336 NAAAPERLEALKYQRIKKPKK--SSKGSSKSKKRSDDSASQTQQLPNSQVLWPDEAVCLRKKKRH 1398
            .:|..||:|||:|||:||.||  .:..:||:::::....|||||...||||.|:||:.|||||:.
Zfish  1334 GSAGSERIEALRYQRVKKAKKVGINNNNSKARRKTGVPPSQTQQPHTSQVLQPEEALYLRKKKKK 1398

Human  1399 -SRPDPFARLSDLCHRQ-LPEDQTAILNSVDHDDPGHATLL 1437
             :|.||:||.|.|.:|: ..|||.|||.|:|..||.|||||
Zfish  1399 LTRQDPYARFSALLYRRPTREDQKAILASMDTADPDHATLL 1439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	66/84 (79%)
		Ig	41..115	CDD:143165	58/73 (79%)
		I-set	139..225	CDD:254352	66/85 (78%)
		IGc2	153..210	CDD:197706	41/56 (73%)
		I-set	229..321	CDD:254352	74/91 (81%)
		Ig	235..321	CDD:299845	68/85 (80%)
		IG_like	331..414	CDD:214653	59/82 (72%)
		Ig	<353..414	CDD:299845	42/60 (70%)
		IG_like	426..505	CDD:214653	66/79 (84%)
		Ig	442..505	CDD:299845	52/63 (83%)
		FN3	510..601	CDD:238020	69/94 (73%)
		FN3	617..699	CDD:238020	57/81 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817		37/58 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081		101/185 (55%)
igsf9bb	XP_009293693.1	IG_like	30..113	CDD:214653	66/84 (79%)
		Ig	41..113	CDD:143165	58/73 (79%)
		IG_like	144..223	CDD:214653	60/78 (77%)
		IGc2	151..208	CDD:197706	41/56 (73%)
		I-set	227..319	CDD:254352	74/91 (81%)
		Ig	<263..319	CDD:299845	42/55 (76%)
		Ig_2	326..414	CDD:290606	62/87 (71%)
		IG_like	329..403	CDD:214653	52/73 (71%)
		IG_like	424..504	CDD:214653	66/79 (84%)
		Ig	440..504	CDD:299845	52/63 (83%)
		FN3	509..604	CDD:238020	69/94 (73%)
		FN3	620..704	CDD:238020	59/83 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330131
Domainoid	1	1.000	857	1.000	Domainoid score	I685
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H19472
Inparanoid	1	1.050	1847	1.000	Inparanoid score	I552
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39380
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	1	1.000	-	-		FOG0002337
OrthoInspector	1	1.000	-	-		otm26685
orthoMCL	1	0.900	-	-		OOG6_104975
Panther	1	1.100	-	-	LDO	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1123
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.410