DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9B and tutl

DIOPT Version :9

Sequence 1:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	1478	Identity:	398/1478 - (26%)
Similarity:	601/1478 - (40%)	Gaps:	341/1478 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    23 AHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFK----FGVPIPIFIKFGYYPPHVD 83
            ||.:.|:...:||..||.|:..|.|..| ...|.|||::|.|    .|..:||:|.:..||.|::
  Fly   128 AHNIPEDAVHITAILGEGVIFNCHVEFP-NDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIE 191

Human    84 PEYAGRASL------HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFT 142
            ..|.||.|.      ...|||.|..:|..|||||||||:.|::......||:|.||.::|||.|:
  Fly   192 EGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFS 256

Human   143 ETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQV-SDGS-LTVTSVSREDRGA 205
            .||...|....|.||.:.|.|.|.|.|.:.|.|:...:..|....: :||: |.::::..||.|.
  Fly   257 VTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDGTELRISTIRHEDIGE 321

Human   206 YTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENV 270
            |||.|.:.:|:..||..:::.|...|:.||.|.|....:..:.:|.|:|.|||:|..||.:...|
  Fly   322 YTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPV 386

Human   271 YFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIY 335
            .....|:.||.|..||:|||..:||:|||:|.|..:|.:|...||||||:|:|||:|...|.|.|
  Fly   387 REVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQY 451

Human   336 VPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPY 400
            :|..:.|.::|.:.:.|....|.|.||.|.|:..:.....:|.:||:......||..|.|.|.||
  Fly   452 LPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPY 516

Human   401 NTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPC---AAAGDPFPVITW-RKVGK-- 459
            |..||.|.|....::::.||.|||.|...|:::.|..:.:.|   .|.|...|.|.| |:.|:
  Fly   517 NAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQL 581

Human   460 -PSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMT 523
             .|:.....:..|::....|.:||.|.::||.:|.|.::.|.|.|.:.||.||||.::..:.:.:
  Fly   582 TESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATES 646

Human   524 TANVSWEPGYDGG--YEQTFSVWMKRAQFGPHDWLSLPV-PPGPSWLLVDTLEPETAYQFSVLAQ 585
            :..:.|.|||.||  |:|.:::|.:.|  |.:||.::.| |.|.:.:.::.|...|.|:|.|:.:
  Fly   647 SITLQWLPGYSGGSEYKQDYTIWFREA--GVNDWQTISVTPSGSTQVTINGLASGTTYEFQVVGR 709

Human   586 NKLGTSAFSEVVTVNTLAFPITTPEPLVLVT---------------------------------- 616
            |.||....|:|:||.||......|..:...|
  Fly   710 NVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEADLLAYFDIYFHTDSRGTLVY 774

Human   617 -------------PPRCLIANRTQQGVLLSWLPPANHSFPIDRYIMEFRVAERWELLDDG-IPGT 667
                         |||.:.......|.|::|..|...:..:..|.:::|...:|:.|:.| |...
  Fly   775 SPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSPLERAHIVKFYTIKYRTDAQWKTLNRGQIRPE 839

Human   668 EGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDI-FPQPDLTEDGLARPVLAGIVATI 731
            |.::..|:|.....|.|||||     .||.|.   .||.:: ||.|...:.   :.:.||:|..|
  Fly   840 ETQYLVKNLVGGRTYYFRVLA-----NSEKSY---ESSDEVKFPVPARVKH---KAITAGVVGGI 893

Human   732 CFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSES 796
            .|...||:.|..|....||:::||.:::    .::..||      ::..:....:...|...|..
  Fly   894 LFFIVAIILSVCAVKICNKRKRRKQEKE----FNMVACR------ITDARNIAANNHHLHNRSTG 948

Human   797 SDDQGQPAAKRMLSPTREKELSLYKKTKRAISS----------------------KKYSVAKAEA 839
            |...||...|:            ||:|:  |||                      ..||....|.
  Fly   949 SISSGQVPLKK------------YKQTR--ISSLTAILIAILHWIWPPDRCTNCHSIYSSPNLED 999

Human   840 EAE------ATTPIELISRGPDGRFVMDPAEM------EPSLKSRR---IEGFPFAEETDMYPEF 889
            ..|      ....:..|.|..|||||:|...:      :.:|:|..   ::|..|........:.
  Fly  1000 GDEDDGGGGRRRSVSRIQRSLDGRFVLDVEGVSKLGYSQQTLESGNVDVVDGGLFERRNSNVSQK 1064

Human   890 RQSDEEN--------------EDPLVPTSVAALKSQLTPLSS---------------SQESYLPP 925
            ..||:..              ..|||.:|     |||:..|:               :::|.:||
  Fly  1065 SSSDDGGFLSRRNFITARASWRRPLVASS-----SQLSLQSAADSARGFLQGLLKIGAKQSAVPP 1124

Human   926 PAYS--------PRFQP--RGLEGPGGLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEP 980
            .:.|        .|:|.  |.......|.|....:        ||.|.....|.||       :.
  Fly  1125 NSQSYFDEAVSGARYQNVLRPYTSSNNLYGNADRS--------RPLHINTISGSLS-------QQ 1174

Human   981 PPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENASNSTLPLTQTPTGGRSPEPWGRPEF 1045
            ...|.|   |.:|.:.||.|...: |.....:....|..|         .||
  Fly  1175 QQLYTP---SRISRIFSSSPQQLQ-PHHQQLLLSSGGSGA---------YPT------------- 1213

Human  1046 PFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPAAYPGILSLEAPKGWAGKSPGR 1110
            .|..|.|   ::|                  |.....:|..:.:.|         :.::.:.|..
  Fly  1214 HFSDLST---VYP------------------PNSAERSSHNLSSRY---------RYYSQELPSL 1248

Human  1111 GPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPV-LPYPEPAEPGAHGGPSTFGLDTRWYEPQ 1174
            ..:        |:...:   .|.|.:|..:...:|: ||.| |:....:...:::...||||
  Fly  1249 RTI--------QEETRR---QQQQKQHPLEDHFVPLQLPSP-PSWRSYYQSQASYRPRTRWY--- 1298

Human  1175 PRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITL 1239
                  ||...|...:..|   |...||||.|..|:.|...         .||.|:
  Fly  1299 ------PRHHSRLFSNRQQ---QHEMLSPLPQLNLNLRNSM---------NPGGLE--------- 1336

Human  1240 QPPAAVSFSRKSTPSTGSPSQSSRSGSPS-YRPAMGFTTLATGYPSPPPGPAPAGPGDSLDVFGQ 1303
                |...||.|:...||.:.|:..||.| :|       |...|.:||..|..:|........||
  Fly  1337 ----ASPESRSSSSGFGSKNTSNHPGSTSEWR-------LLPPYRAPPSPPKHSGYFGGQQAQGQ 1390

Human  1304 TPS-----PRRTGEELLRPETPPPTL------------PTSGTLPPAP 1334
            ||.     ||.|        |||.|:            .|...||.||
  Fly  1391 TPHGSYSYPRAT--------TPPYTMAHWLEMISRLNAATDSNLPKAP 1430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	37/94 (39%)
		Ig	41..115	CDD:143165	33/83 (40%)
		I-set	139..225	CDD:254352	29/87 (33%)
		IGc2	153..210	CDD:197706	20/58 (34%)
		I-set	229..321	CDD:254352	39/91 (43%)
		Ig	235..321	CDD:299845	37/85 (44%)
		IG_like	331..414	CDD:214653	28/82 (34%)
		Ig	<353..414	CDD:299845	21/60 (35%)
		IG_like	426..505	CDD:214653	24/85 (28%)
		Ig	442..505	CDD:299845	21/69 (30%)
		FN3	510..601	CDD:238020	32/93 (34%)
		FN3	617..699	CDD:238020	24/82 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817		8/58 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081		35/194 (18%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	45/113 (40%)
		IG_like	137..229	CDD:214653	37/92 (40%)
		I-set	253..341	CDD:254352	29/87 (33%)
		IGc2	268..331	CDD:197706	21/62 (34%)
		I-set	346..437	CDD:254352	39/90 (43%)
		Ig	349..437	CDD:299845	38/87 (44%)
		Ig	459..530	CDD:299845	23/70 (33%)
		IG_like	549..628	CDD:214653	22/78 (28%)
		IGc2	551..617	CDD:197706	18/65 (28%)
		FN3	633..725	CDD:238020	32/93 (34%)
		FN3	786..874	CDD:238020	27/95 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9436
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1724
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	1	1.000	-	-		FOG0002337
OrthoInspector	1	1.000	-	-		otm40758
orthoMCL	1	0.900	-	-		OOG6_104975
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1123
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770