DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IGSF9B and Ama

DIOPT Version :9

Sequence 1:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens
Sequence 2:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	422	Identity:	98/422 - (23%)
Similarity:	146/422 - (34%)	Gaps:	155/422 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    33 VTARAGESVVLRCDVIHPVTGQPPPYVVEWFK-----------------FGVPIPIFIKFGYYPP 80
            |.|..|:||...|.|  ...||   ..|.|.|                 ..:|
  Fly    42 VVASVGDSVEFNCTV--EEVGQ---LSVSWAKRPSESDTNSVVLSMRNILSLP------------ 89

Human    81 HVDPEYAGRASLHDKA-----SLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPT 140
              |..|....:...|.     :.|::.:...|.|.|||:||:...:..|    ..:.|.|..||.
  Fly    90 --DQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVT----KKLSLQIKTPPV 148

Human   141 FTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGA 205
            ..|..|:.....||.::.:||.|.|.|||.::|.:|...:..:|.:.:::.:|.:.||.|.|||.
  Fly   149 IAENTPKSTLVTEGQNLELTCHANGFPKPTISWAREHNAVMPAGGHLLAEPTLRIRSVHRMDRGG 213

Human   206 YTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENV 270
            |.|.|.:.:|
  Fly   214 YYCIAQNGEG------------------------------------------------------- 223

Human   271 YFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIY 335
              |.|.:| :|:.::     ||  |:                      :.||.| ::..|
  Fly   224 --QPDKRL-IRVEVE-----FR--PQ----------------------IAVQRP-KIAQM----- 250

Human   336 VPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKN--LGWTLMEDGS----IRIEEATEEALGT 394
              |.....:.|.|...|..||| |:|:|.|||..::  :..|....|:    :||:...||..|.
  Fly   251 --VSHSAELECSVQGYPAPTVV-WHKNGVPLQSSRHHEVANTASSSGTTTSVLRIDSVGEEDFGD 312

Human   395 YTCVPYNTLGTMGQSAPARLVLKDPPYFTVLP 426
            |.|...|.||    .|.|||.|    :.||:|
  Fly   313 YYCNATNKLG----HADARLHL----FQTVIP 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	22/103 (21%)
		Ig	41..115	CDD:143165	18/95 (19%)
		I-set	139..225	CDD:254352	26/85 (31%)
		IGc2	153..210	CDD:197706	21/56 (38%)
		I-set	229..321	CDD:254352	7/91 (8%)
		Ig	235..321	CDD:299845	7/85 (8%)
		IG_like	331..414	CDD:214653	27/88 (31%)
		Ig	<353..414	CDD:299845	23/66 (35%)
		IG_like	426..505	CDD:214653	1/1 (100%)
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Ama	NP_731114.2	I-set	33..143	CDD:254352	26/123 (21%)
		Ig	37..127	CDD:299845	22/103 (21%)
		IG_like	154..234	CDD:214653	28/137 (20%)
		IGc2	161..223	CDD:197706	22/61 (36%)
		I-set	254..330	CDD:254352	28/80 (35%)
		IGc2	254..322	CDD:197706	22/68 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10852
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810