DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9B and DIP-theta

DIOPT Version :9

Sequence 1:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens
Sequence 2:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	98/365 - (26%)
Similarity:	156/365 - (42%)	Gaps:	66/365 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    27 REEPEF------VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPE 85
            ::.|:|      ||.......||:|.|.:..|     |.:.|.:......:.|:     .||..:
  Fly   127 KDLPKFGELLQNVTVPVSREAVLQCVVDNLQT-----YKIAWLRVDTQTILTIQ-----NHVITK 181

Human    86 YAGRASLH-DKAS--LRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWV-HLTINAPPTFTETPP 146
            ....:..| :|.:  ||:..|:..|:|||.|       |.:|....|.| :|.:..||...:.|.
  Fly   182 NHRMSITHAEKRAWILRIRDVKESDKGWYMC-------QINTDPMKSQVGYLDVVVPPDILDYPT 239

Human   147 QY-IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL-----GASGKYQVSDGS-LTVTSVSREDRG 204
            .. :..:||.::|:.|.|.|:|.|.:||.:||..|     ||..  ...:|| ||:..|:|.:.|
  Fly   240 STDMVIREGSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEA--VAYNGSFLTIAKVNRLNMG 302

Human   205 AYTCRAYS-IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDE 268
            ||.|.|.: |.........|:|..||.|....:.:...::|:..|.|::||||.::.| |...|.
  Fly   303 AYLCIASNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINY-WMKNDT 366

Human   269 NVY---------FQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYP 324
            .:.         |::..|:.:|      |.|:.|..:|.|.|.||..||||.:..|.....:...
  Fly   367 IIVPGERFVPETFESGYKITMR------LTIYEVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQT 425

Human   325 ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGR 364
            ..:..|.|.:.:..             .|..:||:||:.|
  Fly   426 TTMTTMAPTVSINT-------------VPVVLVKYNKEQR 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	24/93 (26%)
		Ig	41..115	CDD:143165	20/76 (26%)
		I-set	139..225	CDD:254352	30/93 (32%)
		IGc2	153..210	CDD:197706	25/62 (40%)
		I-set	229..321	CDD:254352	28/100 (28%)
		Ig	235..321	CDD:299845	26/94 (28%)
		IG_like	331..414	CDD:214653	7/34 (21%)
		Ig	<353..414	CDD:299845	6/12 (50%)
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	27/109 (25%)
		IG_like	137..230	CDD:214653	27/109 (25%)
		IG_like	240..324	CDD:214653	28/85 (33%)
		IGc2	247..310	CDD:197706	26/64 (41%)
		Ig	327..419	CDD:299845	29/98 (30%)
		IG_like	343..420	CDD:214653	26/83 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910