DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9B and bdl

DIOPT Version :9

Sequence 1:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	212/828 - (25%)
Similarity:	301/828 - (36%)	Gaps:	214/828 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    35 ARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLH------ 93
            |:.|..||..|.:..|... |.||:|.|.|....|     |.:|.............||
  Fly    45 AKVGSHVVFNCYIDFPFDA-PIPYLVHWTKDNKKI-----FTWYEQETSTSELFNGRLHLVENHP 103

Human    94 --DKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGS 156
              .:||:.|..:|..|||||.|:|
  Fly   104 EFGRASVNLTAIRESDQGWYHCQV----------------------------------------- 127

Human   157 ITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTT 221
                  :|.|..|.|                            |.:..||
  Fly   128 ------SFPNRSPSV----------------------------RNNGTAY--------------- 143

Human   222 HLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQ--NDLKLRVRILI 284
            ||.|||...|..||.|.|:...|.|...| ...:|.|...:||  .:.|..|  .||..|..:..
  Fly   144 HLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKHPENSQASWY--KDGVLLQEVQDLVRRFYMGP 205

Human   285 DGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVD 349
            ||:|.|......|.|:|.|...||.|...:|.|:|.:||.|:|:..||.:::|.|....:.|...
  Fly   206 DGSLSIDPTMMSDLGEYECKVRNSDGELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFR 270

Human   350 AEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARL 414
            |.||...::|.|||.........|.....:||:...:..|...|:|||.|||.|||.|.|....:
  Fly   271 ANPPLKNLRWEKDGLLFDSYNVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISV 335

Human   415 VLKDPPYFTVLPGWEYRQEAGRELLIPCAAA---GDPFPVITW-RKVGKPSRSKHSALPSGSLQF 475
            ::..||.|:|.|...|.|:.|....:||.|.   |:..|.|.| ||.|:|..:...:|..|:|..
  Fly   336 IVLRPPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNNRPSIIWGRKDGQPLPADRFSLSGGNLTI 400

Human   476 RALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGY-DGGYEQ 539
            ..|.:.|.|.:||.|||...:|||...|.:...:|.||.::....:.|...:.|:||| ....|
  Fly   401 TGLVEGDRGIYECSATNEAATITAEAELMIENIAPRAPYNLTANSTETCITIRWQPGYLRPNLE- 464

Human   540 TFSVWMKRAQFGPHDWLSLPVPPGPSW------------LLVDTLEPETAYQFSVLAQNKLGTSA 592
             ::||.:..:             .|.|            ..|..|:|...|:|.||:|:|.|...
  Fly   465 -YTVWYRLME-------------APEWRTLRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGM 515

Human   593 FSEVVTVNTLAFPITTPE--------PLVLVTPPR-------CLIANRTQQGVLLSWLPPANHSF 642
            ||:.....||..||...:        .|..||.|.       .|.|...|||.||.|..|.....
  Fly   516 FSKQFRFQTLPSPIRADDFDAQQLQHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHWEHPVQGLE 580

Human   643 PIDRYIMEFRVAERW------------ELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLIS 695
            .:..|      |.||            |..|:       .:..:.|.:||.::.:||||
  Fly   581 GLRLY------AVRWWKEPEHFLIGHAETFDN-------YYQLRHLKEDTLFKVQVLAV------ 626

Human   696 EPSNIAGVSSTDIFPQPDLTED-GLARPVLAGIVATICFLAAAILFSTLAAC-FVNKQRKRKLKR 758
                  |..:....|..:|..| ...|.|.|.|:.:    :..::|...|.| |:..:|.
  Fly   627 ------GTETQQSVPSHELLIDVPSQRKVRALIIGS----SVGVIFLLCALCAFLYVKRS----- 676

Human   759 KKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAK 806
                      |.:.|.:..||.....::..:....|:..|.:.:.:.|
  Fly   677 ----------CLRHLFAKDSSASEDEDTAESGDCDSDEQDQRDRDSIK 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	27/87 (31%)
		Ig	41..115	CDD:143165	25/81 (31%)
		I-set	139..225	CDD:254352	9/85 (11%)
		IGc2	153..210	CDD:197706	7/56 (13%)
		I-set	229..321	CDD:254352	31/93 (33%)
		Ig	235..321	CDD:299845	29/87 (33%)
		IG_like	331..414	CDD:214653	28/82 (34%)
		Ig	<353..414	CDD:299845	21/60 (35%)
		IG_like	426..505	CDD:214653	30/82 (37%)
		Ig	442..505	CDD:299845	25/66 (38%)
		FN3	510..601	CDD:238020	25/103 (24%)
		FN3	617..699	CDD:238020	23/100 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817		7/49 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
bdl	NP_608822.1	IG_like	42..128	CDD:214653	28/135 (21%)
		Ig	43..131	CDD:299845	29/138 (21%)
		I-set	153..242	CDD:254352	31/91 (34%)
		Ig	157..242	CDD:299845	29/87 (33%)
		Ig_2	252..337	CDD:290606	28/84 (33%)
		IG_like	260..327	CDD:214653	22/66 (33%)
		I-set	341..428	CDD:254352	32/86 (37%)
		IGc2	356..419	CDD:197706	23/62 (37%)
		FN3	435..524	CDD:238020	25/103 (24%)
		FN3	554..636	CDD:238020	23/106 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9436
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820