DRSC/TRiP Functional Genomics Resources

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Protein Alignment KDM2A and Kdm2

DIOPT Version :9

Sequence 1:NP_036440.1 Gene:KDM2A / 22992 HGNCID:13606 Length:1162 Species:Homo sapiens
Sequence 2:NP_001262400.1 Gene:Kdm2 / 41090 FlyBaseID:FBgn0037659 Length:1345 Species:Drosophila melanogaster


Alignment Length:1405 Identity:470/1405 - (33%)
Similarity:642/1405 - (45%) Gaps:351/1405 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     1 MEPEEERIRYSQRLRGTMRRRY-EDDGISDDEIEGKRTFDLEEKLHTNKY-NANFVTFMEGKDFN 63
            :.|..:.::..|......|:.| |:..:.|::.||.|.|.:.|||.::|: .|..|..|.|.|..
  Fly    32 LSPNAKGVQRRQLRERKQRKLYLEEWSLGDEDGEGTRGFSVAEKLESSKFAQAGMVREMRGCDLT 96

Human    64 VEYIQRGGLRDPLIFKNSDGLGIKMPDP-DFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWT 127
            |.::|:.|...||:|::..|||::|||| :||||||::||||||::|||||||||.::|||.:|.
  Fly    97 VAFLQQHGFNIPLLFRDKAGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQ 161

Human   128 RYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQ 192
            :||::|:::|  |.||||||||||||:..||.|..|..|||||.:||:.||::|.|.||.:..|.
  Fly   162 QYYDSPQKDR--LLNVISLEFSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMM 224

Human   193 YPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIF 257
            ||||||||||||:.||||||:|||||||||||.:|.|||||||||..||:|||.|:|||||.|||
  Fly   225 YPKVQKYCLMSVKNCYTDFHIDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIF 289

Human   258 LGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPN 322
            .||.|..|.|:.|..|.||.||:||||||||||.:|||||||||||.|..|||..::||.|:||.
  Fly   290 FGDTVEKCARVYLTAGNTFFIPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQ 354

Human   323 KFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSS 387
            ||||||:.||.||||.|||:.:...|||..|   .|||.|                         
  Fly   355 KFRYPFFTEMLWYVLARYVHTLLGHSHLEGE---ASLSED------------------------- 391

Human   388 RRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVH 452
                                                                  :.|.|.  ..|
  Fly   392 ------------------------------------------------------EMAARP--HTH 400

Human   453 LTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWP 517
            |||.||.||:.:|..|..||..||.||:.:.|..|||.||:.|:|........||:|||.:::.|
  Fly   401 LTHHELFGLKEIVMYLYDLPPQKKNVPSLVLDPVALIKDVRSLVERHCKDQQDLAITGVSVLKSP 465

Human   518 KRDKLKFPTRPKVRV-------------------------------------------------- 532
            ...:..|....:.||                                                  
  Fly   466 PGSQPPFLLYDRTRVKQEIKQEIARKNAEVIREQQQLEAGRAREAESDTSQSTGVGSVIGMGAGV 530

Human   533 -----------------------------------PTIPITKPHTMKPAPRLT------------ 550
                                               .|:....|..|..|..|.            
  Fly   531 EYSNGVMKKEQLENGSGVTVGGHGSQPEATFALPTDTLKYRPPKKMHLATALVAAAASSSSGGGG 595

Human   551 PVRPAAASPI--------------VSGA------------------------------------- 564
            ||.....|.:              |:||                                     
  Fly   596 PVAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGGQVGGILNMDNCHSPEGGGAK 660

Human   565 -----------RRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSV 618
                       ||||.||:.|.||.:.:||.|.:|.||.|||||||.||:|::||||:|.||.:.
  Fly   661 LSPNLTGTGQPRRRRTRCKNCAACQRSDCGTCPFCMDMVKFGGPGRAKQTCMMRQCLSPMLPVTA 725

Human   619 TCSLCGEVDQNEET-----------QDFEKKLMECCICNEIVHPGCL--QMDG-------EGLLN 663
            .|..| .:|...:|           .|....||||.:|.||.||.|.  |:||       :|::|
  Fly   726 QCVYC-HLDGWRQTPVSPQTKQLASADGPSALMECSVCYEIAHPDCALSQLDGTEDAADAKGIVN 789

Human   664 EELPNCWECPKCYQEDSSEKAQKR--KMEESDEEAVQAKVLRPLRSCD-----EPLTPPPHSP-- 719
            |:|||.||||.|.:...:...:.|  :..:...|..:..|.......:     ..|.|||...  
  Fly   790 EDLPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVSHGQGGAEGHADGNTLLPPPVGQYN 854

Human   720 ----TSMLQLIHDPVSPRGMVTR-----------------------SSPGAGPSDHHSASRDERF 757
                ||..::....||  |.:|.                       .|||..|   ::...|.:.
  Fly   855 DFVFTSESEMESGTVS--GHMTHWKHGMKRHHQLEVKTERNNSCDTPSPGISP---NAIGGDSKV 914

Human   758 KRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHG-----TSIVP 817
            .:|:......:..:.:.|..:.|.|    |..|.|...|:....|.|.......|     .||..
  Fly   915 GKRRKSDDGTSVSSSMHESNDAPCG----SSAEGAGGAGNANVSTNQWSGSGGGGGSRKKNSIRS 975

Human   818 KL-QAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSA----------- 870
            :| |.:..||..:...|:.:|:  ||.........|.||............:.:           
  Fly   976 QLAQQMLNSSTRVLKKPQYVVR--PASGTGSSSSSGNGGSASATNGISNGSNQSGANSCGAGNGE 1038

Human   871 ---EEGGAARLNGRGSWAQDGDESW-MQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWT 931
               ..||.:..||.|:......::. :...|...:||||.:..|..|..|||.|.....|..||.
  Fly  1039 RGTNNGGLSGSNGLGNQHYSSSQNLALDPTVLKIIFRYLPQDTLVTCCSVCKVWSNAAVDPDLWK 1103

Human   932 KIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALS 996
            |::.|..| :....|:.|::|||..|.|.||.|:|:||.|||.|||.||:|.|..|...||.||.
  Fly  1104 KMNCSEHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAWLVARLPALKNLSLQNCPIQAVLALH 1167

Human   997 TSSCPLLRTLDLRWAVGIKDPQIRDLLTPPAD-KPG-QDNRSKLRNMTDFRLAGLDITDATLRLI 1059
            |..||.|:||||.:..|:.|..|||:|:||.| :|| .|::::||::...:|||.||:|..:|.|
  Fly  1168 TCLCPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKVMKLAGTDISDVAVRYI 1232

Human  1060 IRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYS--LTELNMAGCNKLTDQTLIYLRRIANVT 1122
            .:.:|.|..||||.|..:||..   :..:|:||..:  |||||::.|..:::..|.:|.:...:.
  Fly  1233 TQSLPYLRHLDLSSCQRITDAG---VAQIGTSTTATARLTELNLSACRLVSENALEHLAKCEGLI 1294

Human  1123 LIDLRGCKQITRKACEHFISDLSINSLY--CLSDEKLIQK 1160
            .:|||...|::.::...|.|    ||.:  |:.|.||:::
  Fly  1295 WLDLRHVPQVSTQSVIRFAS----NSKHDLCVRDIKLVER 1330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDM2ANP_036440.1 cupin_like 199..299 CDD:328732 73/99 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 367..389 0/21 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..557 8/121 (7%)
zf-CXXC <576..609 CDD:251032 19/32 (59%)
PHD_KDM2A 619..675 CDD:277113 28/75 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 704..789 20/118 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 839..887 10/61 (16%)
F-box-like 896..934 CDD:315592 15/37 (41%)
leucine-rich repeat 930..954 CDD:275381 7/23 (30%)
AMN1 932..1138 CDD:332986 85/209 (41%)
leucine-rich repeat 955..978 CDD:275381 13/22 (59%)
LRR 1 961..982 14/20 (70%)
leucine-rich repeat 979..1002 CDD:275381 11/22 (50%)
LRR 2 984..1010 14/25 (56%)
leucine-rich repeat 1003..1040 CDD:275381 18/38 (47%)
leucine-rich repeat 1041..1065 CDD:275381 8/23 (35%)
LRR 3 1048..1073 11/24 (46%)
leucine-rich repeat 1066..1095 CDD:275381 11/28 (39%)
LRR 4 1074..1103 11/30 (37%)
leucine-rich repeat 1096..1120 CDD:275381 8/23 (35%)
LRR 5 1104..1128 5/23 (22%)
leucine-rich repeat 1121..1140 CDD:275381 4/18 (22%)
LRR 6 1129..1156 7/28 (25%)
Kdm2NP_001262400.1 cupin_like 231..331 CDD:304367 73/99 (74%)
PRTases_typeI <394..>467 CDD:294217 32/74 (43%)
zf-CXXC 670..716 CDD:251032 26/45 (58%)
PHD_4 721..801 CDD:293471 30/80 (38%)
F-box-like <1073..1108 CDD:289689 14/34 (41%)
leucine-rich repeat 1102..1125 CDD:275381 7/23 (30%)
leucine-rich repeat 1126..1149 CDD:275381 13/22 (59%)
leucine-rich repeat 1150..1173 CDD:275381 11/22 (50%)
AMN1 1166..>1320 CDD:187754 59/160 (37%)
leucine-rich repeat 1174..1213 CDD:275381 18/38 (47%)
leucine-rich repeat 1214..1238 CDD:275381 8/23 (35%)
leucine-rich repeat 1239..1267 CDD:275381 11/30 (37%)
leucine-rich repeat 1268..1292 CDD:275381 8/23 (35%)
leucine-rich repeat 1293..1317 CDD:275381 7/27 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 255 1.000 Domainoid score I2050
eggNOG 1 0.900 - - E1_KOG1633
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H56564
Inparanoid 1 1.050 814 1.000 Inparanoid score I484
Isobase 1 0.950 - 0 Normalized mean entropy S3167
OMA 1 1.010 - - QHG50015
OrthoDB 1 1.010 - - D165446at33208
OrthoFinder 1 1.000 - - FOG0000253
OrthoInspector 1 1.000 - - otm41017
orthoMCL 1 0.900 - - OOG6_104082
Panther 1 1.100 - - LDO PTHR23123
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R626
SonicParanoid 1 1.000 - - X1005
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.910

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