DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYH15 and Myh15

DIOPT Version :9

Sequence 1:	XP_011510861.1	Gene:	MYH15 / 22989	HGNCID:	31073	Length:	1946	Species:	Homo sapiens
Sequence 2:	NP_001159682.1	Gene:	Myh15 / 667772	MGIID:	3643515	Length:	1925	Species:	Mus musculus

Alignment Length:	1926	Identity:	1457/1926 - (75%)
Similarity:	1649/1926 - (85%)	Gaps:	1/1926 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    21 MDLSDLGEAAAFLRRSEAELLLLQATALDGKKKCWIPDGENAYIEAEVKGSEDDGTVIVETADGE 85
            ||||:.|:|.|||||::|: .|.|..|.|||||||:|||:|||||||||.|.|||.|||||.|||
Mouse     1 MDLSEFGDATAFLRRNKAD-PLFQPPAFDGKKKCWVPDGKNAYIEAEVKESGDDGQVIVETRDGE 64

Human    86 SLSIKEDKIQQMNPPEFEMIEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP 150
            .:.|||||:|||||.|.|||||::||.:||||||||||:|||..||||||||:|||.||||||||
Mouse    65 IMRIKEDKLQQMNPEELEMIEDLSMLLYLNEASVLHTLRRRYDHWMIYTYSGIFCVAINPYKWLP 129

Human   151 VYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFAT 215
            |||||||||||.|||||.|||||||||.||||||.|.|||||:||||||:|||||:|.|||||||
Mouse   130 VYQKEVMAAYKRKRRSEVPPHIFAVANRAFQDMLRNGENQSIVFTGESGSGKTVNTKLIIQYFAT 194

Human   216 IAAMIESRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYL 280
            :||:.|.:||.|.|||||::.|.:|||||||||.:|||||||||.||:||||||.||..||.||.
Mouse   195 MAAISEPKKKLGNLEDQIVKMNPLLEAFGNAKTQKNDNSSRFGKLIRIHFGARGTLSFADIQIYF 259

Human   281 LEKSRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATE 345
            ||||||::||.||||||||||||||.:||.::||||.||||||.||||.|.|||||||:|.||||
Mouse   260 LEKSRVVYQQPGERNYHIFYQILSGNQELRNMLLVSTNPSDFHICSCGVVAVESLDDAKEFLATE 324

Human   346 QAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKC 410
            :|:|:||||||||:|||||.||||||||:|||:..||||||||||||||||||||||::|||:|.
Mouse   325 KAIDVLGFLPDEKFGCYKLVGAIMHFGNLKFKRNLREEQLEADGTENADKAAFLMGIHASELLKG 389

Human   411 LIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDIT 475
            ||:||||||||||||.|.::|||.||||||:|:|||||:|||||:|:.|||||:..||:||||.|
Mouse   390 LIYPRIKVGNEYVTRSQNLQQVTYAVGALSQSIYERMFQWLVARMNQVLDAKLTSHFFVGILDTT 454

Human   476 GFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPM 540
            |||||:|||||||||||||||||||||..:|:||||||:||.::|:||.:|||:|||||.|||||
Mouse   455 GFEILDYNSLEQLCINFTNEKLQQFFNQQLFILEQEEYRKEGLDWLSIDYGLDVQACIDFIEKPM 519

Human   541 GILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELVHYAGVVPYNISGW 605
            ||.||||||||.|||||..|||||||:|||||.:.|.|...:|.||.||||.|||||||||||||
Mouse   520 GIFSILEEECMLPKATDQMFKTKLFDHHFGKSAYFQTPTSPEKNFEVHFELAHYAGVVPYNISGW 584

Human   606 LEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKKRKKGASFQTVASLHKENLNKL 670
            :.|||.||||||||:.|||||::||:||...:...||..||||..|||.||..:.||||||:|||
Mouse   585 IGKNKGLLNETVVALLQKSSNKVLANLFTKDIIAGSASQFGEKTHKKGTSFHLITSLHKENINKL 649

Human   671 MTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYC 735
            ||:|||||||||||||||.|||||::||:||||||||||||||.|:|.|.||:.:.|.||||||.
Mouse   650 MTDLKSTAPHFVRCINPNKNKIPGVMDPFLVLQQLRCNGVLEGIRVCCEAFPSWMLYDDFKQRYW 714

Human   736 ILNPRTFPKSKFVSSRKAAEELLGSLEIDHTQYRFGITKVFFKAGFLGQLEAIRDERLSKVFTLF 800
            |||||.|.||||||||||.||:|..|||||..|:.|:|||||||..|.|||..|||::|||||||
Mouse   715 ILNPRIFSKSKFVSSRKATEEVLDFLEIDHPHYQCGVTKVFFKAFILDQLEERRDEKISKVFTLF 779

Human   801 QARAQGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLK 865
            ||||:||||||.|||||||||||.|||.|||||:||||.|||.||||||||.||...|||:||||
Mouse   780 QARARGKLMRITFQKILEERDALALIQENIRAFIAVKNCPWMGLFFKIKPLAKSVGAGEEIAGLK 844

Human   866 EECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEAR 930
            |||||||||||.||.||||||.|||||.||||||.||||||||||||.|||||.|||||::||.:
Mouse   845 EECAQLQKALESSESQREELKTKQVSLVQEKNDLRLQLQAEQETLANSEEQCESLIKSKVELEVK 909

Human   931 VKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVE 995
            :||||.:||||||||||||||||||||||.||||||.|||.:|.||||.|...||||:||||||.
Mouse   910 IKELSRQVEEEEEINSELTARGRKLEDECSELKKEIYDLEAILAKSEKGKCAAEHKVRNLTEEVH 974

Human   996 FLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNC 1060
            .|||::|||:|..|..||..|||.:.||:||||||::|||||||.||:|.|||.||:||||||.|
Mouse   975 SLNEEVSKLSRVVKDAQETQQQTQEQLHIEEEKLSNMSKANLKLAQQIDVLEGDLERERKARMKC 1039

Human  1061 ERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQT 1125
            |||..||:..||:|:|..||||||::.|||:|||||.|:.||||||||||..|:||||.||||||
Mouse  1040 EREKRKLQDELKMNQEGAENLESSRQKLAEQLRKKEFEMGQMNSKVENEKNQVSQLQKMVKELQT 1104

Human  1126 QIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDM 1190
            .|.:|||:||:|||.|||:|||:.||.|||.||||||||.||:||||:||||:||.:|||||.||
Mouse  1105 HILNLKEELESERTIRAKVEREKGDLVQDLEDLNERLEEAGGTSLAQMEITKQQEARFQKLHHDM 1169

Human  1191 EEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKA 1255
            ||.|.|||.||||||||||::|||||||||:||||:..||:|||||||:|||||.||:||.||||
Mouse  1170 EETTRHFEATSASLKKRHAENLAELEGQVEHLQQVRLVLEQDKSDLQLQVDDLLNRVDQMARAKA 1234

Human  1256 NAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNF 1320
            ||||||.|||.||:||..|||:|||||:||..|||||.||||||.:|||||||||:|||||||||
Mouse  1235 NAEKLCGLYERRLNEANTKLDEVTQLAHDLTTQKTKLQSESGEFFKRLEEKEALISQLSREKSNF 1299

Human  1321 TRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRM 1385
            |||:|:||.|||:|::|||||:||||.|:.|.|||||||||||||||||||.|||.|.|.||||.
Mouse  1300 TRQVEELRAQLEEESRSQSALSHALQSAKHDYDLLREQYEEEQEVKAELHRALSKGNKETVQWRA 1364

Human  1386 KYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSA 1450
            |||::.:|||||||:|||:||||||||||||.|:||:|||||||||:||||||||||||||.||.
Mouse  1365 KYEHDAMQRTEDLEEAKKKLAIRLQEAAEAMEVSNAKNASLERARHRLQLELGDALSDLGKARSV 1429

Human  1451 AARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENK 1515
            ||.|.|||..|.|||..||||.:|:|.||.|||||.:|||:|:|..:...|||...||||:|:|:
Mouse  1430 AAALGQKQQHSDKALTSWKQKLDETQELLQASQKETRALSSEVLTFRQACEESTEAQETLKRQNQ 1494

Human  1516 NLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEA 1580
            :|||:|.:||||||||.|||.|:||.|||||:|||||||.||||||||||||||||.|||||.||
Mouse  1495 DLQEQICSLTNQVREGIKNLAEVEKAKKLIEQEKTEVQVRLEETEGALERNESKILRFQLELSEA 1559

Human  1581 KAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCAN 1645
            |||||||||||:||.|..|.|.|..:.||||:||.||.||||.|||:||||.||.|||:||..||
Mouse  1560 KAELERKLSEKEEEAERLREKHQQAMGSLQSNLDLEASSRIEATRLRKKMEGDLKEMEIQLCAAN 1624

Human  1646 RQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERG 1710
            ||||:.|::|||||.|:|||..|||||...|.|||||||:||:|..|||||||:||:||||||||
Mouse  1625 RQVSQMTRALGQLQGQMKDLHQQLDDSIYQNKDLKEQVALAEQRTVLLQSELEELRTLQEQTERG 1689

Human  1711 RRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAA 1775
            |:|:|:||||||||||||:||||||||||||||||||::||||.|::|.||.|||||||.|.|||
Mouse  1690 RKLAEKELLEATERINLFHTQNTSLLSQKKKLEADVAQVQKEAGEMLQACQKAEEKAKKTAAEAA 1754

Human  1776 NLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEG 1840
            |:||||||:|||.|||||.|:||||||.||||||.||||.|::||:|||||||||||:||||||.
Mouse  1755 NMSEELKKEQDTNAHLERMRKNMEQTIKDLQKRLDEAEQTAVLGSKKQIQKLESRVRDLEGELES 1819

Human  1841 EIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYL 1905
            |:||||||||.||||||.|||||||||||||||||||...||||||||:||||||.||.||||||
Mouse  1820 EVRRSAEAQREARRLERGIKELTYQAEEDKKNLSRMQALSDKLQLKVQSYKQQVEAAEAQANQYL 1884

Human  1906 SKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
            ||||||||||||.|||||.||||||||:.||:|..|||:||
Mouse  1885 SKYKKQQHELNEAKERAEAAESQVNKLRAKAKELEKKVREE 1925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYH15	XP_011510861.1	Myosin_N	52..90	CDD:280832	28/37 (76%)
		Myosin_head	105..778	CDD:278492	508/672 (76%)
		MYSc_Myh15_mammals	117..778	CDD:276892	500/660 (76%)
		Myosin_tail_1	859..1935	CDD:279860	818/1075 (76%)
		CENP-Q	1017..1164	CDD:289839	103/146 (71%)
		DUF2317	<1487..1600	CDD:302887	81/112 (72%)
		DUF4337	<1864..>1940	CDD:290935	64/75 (85%)
Myh15	NP_001159682.1	Myosin_N	31..69	CDD:280832	28/37 (76%)
		Myosin_head	84..757	CDD:278492	508/672 (76%)
		MYSc_Myh15_mammals	96..757	CDD:276892	500/660 (76%)
		Myosin_tail_1	838..1914	CDD:279860	818/1075 (76%)
		NBP1	<1004..>1136	CDD:285709	93/131 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83961384
Domainoid	1	1.000	1546	1.000	Domainoid score	I613
eggNOG	1	0.900	-	-		E2759_KOG0161
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18929
Inparanoid	1	1.050	2836	1.000	Inparanoid score	I705
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		oto113745
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	LDO	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R14854
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.290