DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH15 and didum

DIOPT Version :9

Sequence 1:XP_011510861.1 Gene:MYH15 / 22989 HGNCID:31073 Length:1946 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2072 Identity:530/2072 - (25%)
Similarity:893/2072 - (43%) Gaps:474/2072 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    36 SEAELLLLQATALDGKKKCWIPDGENAYIEAEVKGSEDDGTVIVETADGESLSIKEDKIQQ---- 96
            |..|:|..|..      |.|:|..:..:..|.::.|...|...::... :|..:||.|::.    
  Fly     2 SSEEMLYAQGA------KIWVPHADLVWESATLEESYRKGAGFLKICT-DSGKLKEVKLKADGSD 59

Human    97 ----MNPPEFEMIEDMAMLTHLNEASVLHTLKRRY-GQWMIYTYSGLFCVTINPYKWLPVYQKEV 156
                .||.......|:..|::|:|..|||.|:.|: .:.:||||.|:..|.||||..:|:|...:
  Fly    60 LPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124

Human   157 MAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAMIE 221
            :.||:|....:..|||||:|..|:..:.....|.||:.:|||||||||::|:.::|||.:.    
  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVG---- 185

Human   222 SRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHF-GARGM--LSSVDIDIYLLEK 283
            ..:.:..:|.:::.::.|:||||||||.|||||||||||.::.| ...|:  |....:..|||||
  Fly   186 GSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEK 250

Human   284 SRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSC-GAVTVESLDDAEELLATEQA 347
            |||::|..||||||||||:.:.:.:..:|:|  .:...|.|.:. ||..:|.:.|||:...|.||
  Fly   251 SRVVYQAQGERNYHIFYQLCAARSKYPELVL--DHQDKFQFLNMGGAPEIERVSDAEQFNETVQA 313

Human   348 MDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPRE--EQLEADGTE------NADKAAFLMGINS 404
            |.:|||...:.....|:...|:|.||::..:|..|  |:.::|..:      :....|.|:.:::
  Fly   314 MTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSA 378

Human   405 SELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFI 469
            .:|.:.|:..:|:..||||....:||....|..||:|.:|.::|:::|..:|::|:....:..||
  Fly   379 DDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFI 443

Human   470 GILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACID 534
            |:|||.|||..|.||.||.|||:.||||||.||.|:|.||||||.||.|.|..|.| .|.|.|||
  Fly   444 GVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCID 507

Human   535 LIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKF-EAHFELVHYAGVV 598
            |||..:|:|.:|:|||..||.:|.::..||. ....|..|.:||     :| ...|.:.|::..|
  Fly   508 LIESRLGVLDLLDEECRMPKGSDESWAGKLI-GKCNKFPHFEKP-----RFGTTSFFIKHFSDTV 566

Human   599 PYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFE----NYMSTDSA----------IPFGEK- 648
            .|:::|:||||:|.:::.:..|..:|:..|...:..    :.:..|||          |..|.| 
  Fly   567 EYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQ 631

Human   649 -----KRKKGASFQ---TVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQL 705
                 :|:...|.|   ||.|..:|:|..|::.|.:|.||:||||.||.:|:....:...::|||
  Fly   632 QGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQL 696

Human   706 RCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEELLGSLEIDHTQYRF 770
            |..||||..||...|||:|..|.||..||.:|..|:  |......:.:...::.....|..:|||
  Fly   697 RACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRS--KLDKNDMKLSCRNIVMKWIQDEDKYRF 759

Human   771 GITKVFFKAGFLGQLEAIRDE-----------------------RLSKVFTLFQARAQGKLMRIK 812
            |.|::||:||.:..||.:|..                       |:.||....|..|:|.|.|.:
  Fly   760 GNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER 824

Human   813 FQKILEERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEK 877
            .||:.|.|..|||.::       .:.|...|.:.:::         ..::|: :..|:...|..|
  Fly   825 TQKMREARAGLILSKY-------ARGWLCRRRYLRLR---------HSISGI-QTYARGMLARNK 872

Human   878 SEFQREELKAKQVS------------LTQEKNDLILQ--------------LQAEQETLANVEEQ 916
            ....|:..:|.|:.            ..:.:|.:|.|              ::||.:|::::|.:
  Fly   873 FHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENK 937

Human   917 CEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKR 981
                   .:.||.::..:.:|::|....||              .||.:..::..:.:|.|. |:
  Fly   938 -------YMGLENKIISMQQRIDELNRDNS--------------NLKHKTSEISVLKMKLEL-KK 980

Human   982 TTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDL-HMEEEKLS---SLSKANLKLEQQ 1042
            |.|.:.||:....:..::.|..||:..:..::...|.|::. |.:||.:|   :..:.|.:|.:|
  Fly   981 TLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQ 1045

Human  1043 VDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRK--KELELSQMNSK 1105
            :||:   ::..:.|.:|            :.|:|.....|...|.|.|..::  |:.|:      
  Fly  1046 IDEI---IDMAKNAEVN------------QRNQEDRMLAEIDNRELNEAYQRAIKDKEV------ 1089

Human  1106 VENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERE------RADLTQDL---ADLNER 1161
            :|||..:       :||..:::......|.|.:.:.|..:.|      .|..|.|:   .||..:
  Fly  1090 IENENFM-------LKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSK 1147

Human  1162 LEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRH---ADSLAELEGQVENLQ 1223
            ......|:...:::....|.:.|| |:.::|..:       .|..||   .||....|.:|||  
  Fly  1148 NYSYNDSTSLVVKLRSILEEEKQK-HKVLQEQYI-------KLSSRHKPTEDSFRVSELEVEN-- 1202

Human  1224 QVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQ 1288
                  ||    |:.|.|.|.|.:      |...|                       .|:|.||
  Fly  1203 ------EK----LRSEYDQLRTSI------KHGVE-----------------------INELNAQ 1228

Human  1289 KTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCD 1353
            ...|..|    :||..|:...:..:..::|...|.:|                ..:||....|.:
  Fly  1229 HAALQEE----VRRRREECIQLKAVLLQQSQSMRSLE----------------PESLQMRGNDVN 1273

Human  1354 LLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLE---DAKKELAIRLQEAAEA 1415
            .|.|.:..::.:..:|...|..:..|       :.:.:::.|:::|   :.|.||...:.|:.:.
  Fly  1274 ELMEAFHSQKLINRQLESELKAITEE-------HNSKLVEMTQEIERLNNEKDELQKVMFESIDE 1331

Human  1416 MGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKA-LADWKQKHEESQALL 1479
            ...:|.  .:|.:....|:.||..|:        |...|.|::|:...| |..::|         
  Fly  1332 FEDSNV--DTLRQNDRYLRRELQKAV--------AQFLLVQEELKLANAKLKAYRQ--------- 1377

Human  1480 DASQKEVQALSTELLKLKNTYEESIVGQETLRRENKN---------------LQEEISNLTNQVR 1529
            |..|.| ..:..|:::.|:....:.||....:::::|               ||..:|.||.:..
  Fly  1378 DGGQLE-HKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTV 1441

Human  1530 EGT---------------KNLTEM-EKVKKLIEEEKTEVQV-TLEETEGALER------NESKIL 1571
            .|.               .:||.. :.|::|:  .|..:|: .:..|...:|.      |...:|
  Fly  1442 VGLLPGFPAYLIFMCIRYTDLTNADDDVRELL--SKFVIQIKKMHRTPHPIENRVIWLVNSITLL 1504

Human  1572 HFQL------ELLEAKAELERKLSEKDEEIENFRR--------KQQCTIDSLQSSLDSEAKSRIE 1622
            :...      |.::...|.:.:...|:..:..:||        ..|..|..:|..||.:....| 
  Fly  1505 NLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAI- 1568

Human  1623 VTRLKKKMEEDLNEMELQLSCANRQV----SEAT-----------------KSLGQLQIQIKDLQ 1666
                       ||..|:|   ..||.    |.||                 :.:|||:...|..|
  Fly  1569 -----------LNNDEIQ---RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQ 1619

Human  1667 MQLDDSTQLNSDLKEQV---------AVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEAT 1722
                 ...|::...||:         |||  .|.|:      ||......|.|..:         
  Fly  1620 -----HFGLDNCYAEQIFHQLLYFICAVA--LNCLM------LRGDICMWETGMII--------- 1662

Human  1723 ERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDT 1787
             |.|:...::   ..:.||:..||........:|.|                  |.:..|.:||.
  Fly  1663 -RYNIGCIED---WVRSKKMSNDVLTALAPLNQVSQ------------------LLQSRKSEQDV 1705

Human  1788 IAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGA 1852
                        |||.||...|:.|:.:.:|.|.|        :.:.|.|:..........:..|
  Fly  1706 ------------QTICDLCTSLSTAQVLKVMKSYK--------LDDYESEITNVFLEKLTEKLNA 1750

Human  1853 RRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYK-QQVEV-AETQANQYLSK 1907
            |::::        :..|:..:.:...|..|:..:..:.| :.:|: :....:::|:|
  Fly  1751 RQMQK--------SNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDEFLTK 1799

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH15XP_011510861.1 Myosin_N 52..90 CDD:280832 7/37 (19%)
Myosin_head 105..778 CDD:278492 267/709 (38%)
MYSc_Myh15_mammals 117..778 CDD:276892 263/697 (38%)
Myosin_tail_1 859..1935 CDD:279860 224/1181 (19%)
CENP-Q 1017..1164 CDD:289839 35/161 (22%)
DUF2317 <1487..1600 CDD:302887 24/156 (15%)
DUF4337 <1864..>1940 CDD:290935 7/46 (15%)
didumNP_724569.1 MYSc 65..778 CDD:214580 274/727 (38%)
MYSc_Myo5 84..767 CDD:276831 263/697 (38%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 29/130 (22%)
coiled coil 1049..1068 CDD:293879 4/33 (12%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 34/169 (20%)
Myo5_CBD 1424..1792 CDD:271254 84/456 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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