Protein Alignment MYH15 and myhz2

DIOPT Version :10

• Sequence 1: XP_011510861.1
• Gene: MYH15 / 22989
• HGNCID: 31073
• Length: 1946
• Species: Homo sapiens
• Sequence 2: NP_694514.2
• Gene: myhz2 / 246275
• ZFINID: ZDB-GENE-020604-1
• Length: 1935
• Species: Danio rerio
• Alignment Length: 1935
• Identity: 1137/1935 - (58%)
• Similarity: 1516/1935 - (78%)
• Gaps: 16/1935 - (0%)

Human    22 DLSDLGEAAAFLRRSEAELLLLQATALDGKKKCWIPDGENAYIEAEVKGSEDDGTVIVETADGES 86
            :::..|:||.|||:.|.|.:..|:...|.|..|::.|.:..|::..:| |:|.|.|.|.|.|.::
Zfish     6 EMAIYGKAAIFLRKPEKERIEAQSKPFDAKTACYVVDDKELYVKGTIK-SKDGGKVTVVTLDTQT 69

Human    87 LS-IKEDKIQQMNPPEFEMIEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP 150
            .. :|||.:..||||:|:.||||||:|||||.|||:.||.||..|||||||||||.|:|||||||
Zfish    70 EKVVKEDDVHPMNPPKFDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP 134

Human   151 VYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFAT 215
            ||..||:|||:||:|.|||||||:|::||:|.||.:|||||:|.|||||||||||:|.:||||||
Zfish   135 VYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFAT 199

Human   216 IAAMIESRKK-------QGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSS 273
            :|.....:||       ||:|||||:.||.:|||:|||||:|||||||||||||:|||..|.|:|
Zfish   200 VAVQGGDKKKEQAAGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLAS 264

Human   274 VDIDIYLLEKSRVIFQQAGERNYHIFYQILSGQK-ELHDLLLVSANPSDFHFCSCGAVTVESLDD 337
            .||:.||||||||.||...||.||||||:::..| ||.::.|::.||.||..||.|.:||.|:||
Zfish   265 ADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDD 329

Human   338 AEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGI 402
            .|||:||:.|:|||||..:||.|.||.|||::|.||||||||.||||.|.||||.|||.|:|:|:
Zfish   330 KEELVATDTAIDILGFTGEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIAYLLGL 394

Human   403 NSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQF 467
            ||::::|.|.:||:|||||:||:|||:.||..:|.|||||:|||||.|:|.|||:.||.|..|.|
Zfish   395 NSADMLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVIRINQMLDTKQQRNF 459

Human   468 FIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQAC 532
            |||:|||.||||.::||:|||||||||||||||||.|||||||||||||.|.|..|.||:||.||
Zfish   460 FIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAAC 524

Human   533 IDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELVHYAGV 597
            |:|||||:||.||||||||||||||.:||.||:|.|.||....|||||.|.|.||||.||||||.
Zfish   525 IELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAHFSLVHYAGT 589

Human   598 VPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKK--RKKGASFQTVA 660
            |.|||||||:||||.|||:||.::||||.:|||:|:...:....    |.||  :|||.|.|||:
Zfish   590 VDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETG----GGKKGGKKKGGSMQTVS 650

Human   661 SLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRL 725
            |..:|||.||||||:||.||||||:.||.:|.||:::.:||:.||||||||||.||||:|||:|:
Zfish   651 SQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRI 715

Human   726 QYADFKQRYCILNPRTFPKSKFVSSRKAAEELLGSLEIDHTQYRFGITKVFFKAGFLGQLEAIRD 790
            .|.||||||.:||....|:.:|:.::||:|:||||::::|.:||||.||||||||.||.||.:||
Zfish   716 LYGDFKQRYKVLNASVIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRD 780

Human   791 ERLSKVFTLFQARAQGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSS 855
            |:|:.:.|:.||..:..|||.:|.|::|.|:::..||:|||:||.||:||||::::|||||:||:
Zfish   781 EKLATLVTMTQALCRAYLMRREFVKMMERRESIYTIQYNIRSFMNVKHWPWMKVYYKIKPLLKSA 845

Human   856 EVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWL 920
            |..:|:|.:||:..:.::||.|:|.:::||:.|.|:|.||||||.|.:.:|.|.|::.||:||.|
Zfish   846 ETEKELATMKEDFVKCKEALAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGL 910

Human   921 IKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEH 985
            |||||||||::||.:||:|:|||||:||||:.|||||||.||||:|||||..|.|.||||..||:
Zfish   911 IKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 975

Human   986 KVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGAL 1050
            ||||||||:...:|.|:||.:..|.:|||||||||||..||:|:::|:|:..|||||||:|||:|
Zfish   976 KVKNLTEEMASQDESIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSL 1040

Human  1051 EQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQ 1115
            |||:|.||:.||...||||:|||.:||:.:||:.::...|:::||:.|.:|:.||:|:|:.|.||
Zfish  1041 EQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKIKKKDFETAQLLSKIEDEQSLGAQ 1105

Human  1116 LQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQE 1180
            |||.:||||.:|::|:|::||||..|||:|::||||:::|.:::|||||.||::.||:|:.||:|
Zfish  1106 LQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKRE 1170

Human  1181 TKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLT 1245
            .:||||.||:||:||..|.|:|:|:|:.|||:|||..|::|||:|||||||:||:.::|:|||.:
Zfish  1171 AEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSS 1235

Human  1246 RVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALI 1310
            .:|.:.:||||.||:|...|::|.|..:|.|:..:..|||:||:.:|.:|:|||.|:|||||||:
Zfish  1236 NMEAVAKAKANLEKMCRTVEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALV 1300

Human  1311 NQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSK 1375
            :||:|.|..||:|||:|:.|:|:|.|:::|||||:|.|:.||||||||:|||||.||||.|.:||
Zfish  1301 SQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSK 1365

Human  1376 VNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDA 1440
            .|:|:.|||.|||.:.|||||:||::||:||.|||||.|.:...|::.||||:.:.:||.|:.|.
Zfish  1366 ANSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDL 1430

Human  1441 LSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIV 1505
            :.|:.:..:.||.||:||....|.||:||||:||.||.|:.:|||.::|||||.|:||:|||::.
Zfish  1431 MIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLD 1495

Human  1506 GQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKI 1570
            ..|||:|||||||:|||:||.|:.|..|::.|:||.||.:|.||.|:|..|||.||.||..||||
Zfish  1496 QLETLKRENKNLQQEISDLTEQLGETGKSIHELEKAKKTVETEKAEIQTALEEAEGTLEHEESKI 1560

Human  1571 LHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLN 1635
            |..||||.:.|.|::|||:|||||:|..:|..|...:::||:||||.:||.:..|:|||||.|||
Zfish  1561 LRVQLELNQVKGEIDRKLAEKDEEMEQIKRNSQRVTEAMQSTLDSEVRSRNDALRIKKKMEGDLN 1625

Human  1636 EMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDL 1700
            |||:|||.||||.:||.|.|..:|.|:||.|:.|||:.:...|:|||||:.||||:|:|||:|:|
Zfish  1626 EMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEEL 1690

Human  1701 RSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEE 1765
            |:..|||||||:::|:||::|:||:.|.::||||||:.|||||.|:.::|.|.|:.|||.:||||
Zfish  1691 RAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLETDLVQIQSEVEDTVQEARNAEE 1755

Human  1766 KAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESR 1830
            |||||..:||.::|||||:|||.|||||.::|:|.|:.|||.||.|||.:|:.|.:||:||||||
Zfish  1756 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESR 1820

Human  1831 VRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVE 1895
            |||||.|:|.|.||.|:|.:|.|:.||.:||||||.||||||::|:|..:|||||||:.||:|.|
Zfish  1821 VRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSE 1885

Human  1896 VAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQE 1945
            .||.|||.:|||.:|.||||.|.:|||::||||||||:.|:|:.||..:|
Zfish  1886 EAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDAGKAKEE 1935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH15	XP_011510861.1	COG5022	53..1460	CDD:227355	839/1417 (59%)
		MYSc_Myh15_mammals	117..778	CDD:276892	433/670 (65%)
		SMC_prok_B	1093..1932	CDD:274008	478/838 (57%)
myhz2	NP_694514.2	Myosin_N	33..78	CDD:460670	16/45 (36%)
		MYSc_class_II	101..768	CDD:276951	433/670 (65%)
		Myosin_tail_1	848..1925	CDD:460256	615/1076 (57%)